Zobrazeno 1 - 10
of 842
pro vyhledávání: '"D Chevalier"'
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Background The role of pathogen genotype in determining disease severity and immunopathology has been studied intensively in microbial pathogens including bacteria, fungi, protozoa and viruses but is poorly understood in parasitic helminths.
Externí odkaz:
https://doaj.org/article/4e10fc823c6c49ddad7569ac2cabd491
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background The trematode parasite Schistosoma mansoni uses an aquatic snail intermediate and a vertebrate definitive host to complete its life cycle. We previously showed that a key transmission trait—the number of cercariae larvae shed fr
Externí odkaz:
https://doaj.org/article/aecb4aeb708d44dd860738d62a09f4e1
Autor:
Winka Le Clec’h, Frédéric D. Chevalier, Marina McDew-White, Vinay Menon, Grace-Ann Arya, Timothy J.C. Anderson
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 1508-1526 (2021)
Both theory and experimental data from pathogens suggest that the production of transmission stages should be strongly associated with virulence, but the genetic bases of parasite transmission/virulence traits are poorly understood. The blood fluke S
Externí odkaz:
https://doaj.org/article/450aff1361ae4c1bb4c6a2fada95e3de
Autor:
Philip T. LoVerde, Sevan N. Alwan, Alexander B. Taylor, Jayce Rhodes, Frédéric D. Chevalier, Timothy JC. Anderson, Stanton F. McHardy
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 140-147 (2021)
Human schistosomiasis is a debilitating, life-threatening disease affecting more than 229 million people in as many as 78 countries. There is only one drug of choice effective against all three major species of Schistosoma, praziquantel (PZQ). Howeve
Externí odkaz:
https://doaj.org/article/719a25b8fb284e2380401b9a6d25e8f0
Autor:
Philip T. LoVerde, Sevan N. Alwan, Alexander B. Taylor, Jayce Rhodes, Frédéric D. Chevalier, Timothy Jc Anderson, Stanton F. McHardy
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 18, Iss , Pp 103- (2022)
Externí odkaz:
https://doaj.org/article/db504295d1b64fbdba4f77b5d55ff3c7
Autor:
Anastasia R. Rugel, Meghan A. Guzman, Alexander B. Taylor, Frédéric D. Chevalier, Reid S. Tarpley, Stanton F. McHardy, Xiaohang Cao, Stephen P. Holloway, Timothy J.C. Anderson, P. John Hart, Philip T. LoVerde
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 8-15 (2020)
Human schistosomiasis is a disease which globally affects over 229 million people. Three major species affecting humans are Schistosoma mansoni, S. haematobium and S. japonicum. Previous treatment of S. mansoni includes the use of oxamniquine (OXA),
Externí odkaz:
https://doaj.org/article/d86b55a8a7f64c9c9976e5f440e1e224
Autor:
Winka Le Clecʼh, Robbie Diaz, Frédéric D. Chevalier, Marina McDew-White, Timothy J. C. Anderson
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background Parasite traits associated with transmission success, such as the number of infective stages released from the host, are expected to be optimized by natural selection. However, in the trematode parasite Schistosoma mansoni, a key
Externí odkaz:
https://doaj.org/article/2134c2ac88804132a6e02e3fa2d8dc8f
Autor:
Meghan A. Guzman, Anastasia Rugel, Sevan N. Alwan, Reid Tarpley, Alexander B. Taylor, Frédéric D. Chevalier, George R. Wendt, James J. Collins, Timothy J. C. Anderson, Stanton F. McHardy, Philip T. LoVerde
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1416 (2022)
Oxamniquine (OXA) is a prodrug activated by a sulfotransferase (SULT) that was only active against Schistosoma mansoni. We have reengineered OXA to be effective against S. haematobium and S. japonicum. Three derivatives stand out, CIDD-0066790, CIDD-
Externí odkaz:
https://doaj.org/article/e5605799150f4a7ab88576d43918dca9
Autor:
Meghan A Guzman, Anastasia R Rugel, Reid S Tarpley, Sevan N Alwan, Frédéric D Chevalier, Dmytro P Kovalskyy, Xiaohang Cao, Stephen P Holloway, Timothy J C Anderson, Alexander B Taylor, Stanton F McHardy, Philip T LoVerde
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008517 (2020)
Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals,
Externí odkaz:
https://doaj.org/article/63cb9a6c7eed407f9070e62dc9bc98ef
Publikováno v:
Journal of European CME, Vol 9, Iss 1 (2020)
A survey of Blackpool Foundation Year One (FY1) doctors found limited training about being on-call. We could not find any direct mention in Tomorrow’s Doctors for preparing undergraduates for this.1 Working out of hours, on-call and with a reduced
Externí odkaz:
https://doaj.org/article/fa6c36acbc6a4dce88000212185f2bb2