Zobrazeno 1 - 10 of 26 pro vyhledávání: '"D C van Gent"'
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Abstract P1-06-06: Direct ex vivo observation of homologous recombination defect reversal after DNA damaging chemotherapy in metastatic breast cancer patients
Autor: W. Dinjens, Titia G. Meijer, Nicole S. Verkaik, D C van Gent, C.H.M. van Deurzen, TD Den Toom, Agnes Jager, H.J. Dubbink, Roland Kanaar
Publikováno v: Cancer Research. 79:P1-06
Introduction Better predictive biomarkers for response to Poly ADP-Ribose inhibitors (PARPi) are required, since on the one hand evidence is emerging that PARPi are also effective beyond germline BRCA mutated (gBRCAm) cancers and on the other hand gB
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d85843c27e4e4e97b67731d632f84294
https://doi.org/10.1158/1538-7445.sabcs18-p1-06-06
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3
PO-492 Ex vivo functional homologous recombination (HR) test detects BRCA reversal and resistance to PARPi in metastatic breast cancer patients
Autor: C.H.M. van Deurzen, Titia G. Meijer, H.J. Dubbink, D C van Gent, Nicole S. Verkaik, D. Den Toom, Agnes Jager, W. Dinjens, Roland Kanaar
Publikováno v: ESMO Open. 3:A422-A423
Introduction Better predictive biomarkers for response to Poly ADP-Ribose inhibitors (PARPi) are required, since on the one hand evidence is emerging that PARPi are also effective beyond germline BRCA mutated (gBRCAm) cancers and on the other hand gB
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccbac78ae2401ca639ddb94d1261f3b5
https://doi.org/10.1136/esmoopen-2018-eacr25.994
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6
From DNA damage to chromosome aberrations: Joining the break
Autor: David J. Chen, Marco Durante, G. Obe, S. Conrad, D C van Gent, Adayapalam T. Natarajan, Joel S. Bedford, Michael N. Cornforth
Publikováno v: Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 756(1-2), 5-13. Elsevier
Despite many years of experimental studies on radiation-induced chromosomal aberrations, and the recent progress in elucidating the molecular mechanisms of the DNA damage response, the link between DNA double-strand break repair and its expression as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73550aa68f5ac6f6836a836cd98c53cf
https://doi.org/10.1016/j.mrgentox.2013.05.014
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7
Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling
Autor: N J F van den Broek, Judith Campisi, D Putavet, D C van Gent, Boudewijn M.T. Burgering, P L J de Keizer, J.H.J. Hoeijmakers, M P Baar, Arjan B. Brenkman, K.A.T. Naipal, Flore Kruiswijk, Renuka Sivapatham, P.J. van der Spek, Wim H. J. Kruit, Sebastian C. Hasenfuss
Publikováno v: Oncogene, 35(17), 2166-2177. Nature Publishing Group
Oncogene
Oncogene, 35(17), 2166. Nature Publishing Group
Melanoma is the most lethal form of skin cancer and successful treatment of metastatic melanoma remains challenging. BRAF/MEK inhibitors only show a temporary benefit due to rapid occurrence of resistance, whereas immunotherapy is mainly effective in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d159499dd1b43e3fd7972e28f4a7040
https://pure.eur.nl/en/publications/65ad3aa2-05f7-42e8-9673-cab4e71557c6
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8
Artemis splice defects cause atypical SCID and can be restored in vitro by an antisense oligonucleotide
Autor: Albert Pastink, Hanna IJspeert, M.E.L. van der Burg, A.C. Lankester, M.J.D. van Tol, Qiang Pan-Hammarström, Corry M.R. Weemaes, D C van Gent, Wouter W. Wiegant, Adilia Warris, J.M. van den Berg, M C van Zelm, J. J. M. Van Dongen
Publikováno v: Genes and immunity, 12(6), 434-444. Nature Publishing Group
Genes and Immunity, 12(6), 434-444. Nature Publishing Group
Genes and Immunity, 12(6), 434-444
Genes and Immunity
Genes and Immunity, 12, 434-44
Genes and Immunity, 12, 6, pp. 434-44
Artemis deficiency is known to result in classical T-B- severe combined immunodeficiency (SCID) in case of Artemis null mutations, or Omenn's syndrome in case of hypomorphic mutations in the Artemis gene. We describe two unrelated patients with a rel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683bad92424315d7c1084a1deab5fae8
https://doi.org/10.1038/gene.2011.16
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9
PO-015 DNA damage response reporters in breast cancer
Autor: Hanny Odijk, Roland Kanaar, D C van Gent, M. Kuijten, Maarten W. Paul
Publikováno v: ESMO Open. 3:A26
Introduction The DNA damage response is a powerful tool of the cell to protect the genome by preventing replication of genetic mutations. A well-known defect in DNA repair is caused by mutations in the BRCA gene, present in several hereditary breast
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b529a8e505d05deb05e7d361bcf5ede
https://doi.org/10.1136/esmoopen-2018-eacr25.60
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10
PO-462 Functional ex vivo assay reveals homologous recombination deficiency in breast cancer beyond BRCA gene defects
Autor: Agnes Jager, Jwm Martens, Anieta M. Sieuwerts, Nicole S. Verkaik, Titia G. Meijer, H.J. Dubbink, D C van Gent, Roland Kanaar, C.H.M. van Deurzen
Publikováno v: ESMO Open. 3:A412
Introduction Tumours of germline BRCA1/2 mutated carriers show homologous recombination (HR) deficiency (HRD), resulting in impaired DNA double strand break (DSB) repair and high sensitivity to Poly-(ADP-Ribose)-Polymerase (PARP) inhibitors. Although
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d855b7ac7d785238c91ef2032e876e9
https://doi.org/10.1136/esmoopen-2018-eacr25.969
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