Výsledky vyhledávání

Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells

Autor: D C Shugars, J V Garcia, R Swanstrom, S. J. Anderson

Publikováno v: Journal of Virology. 67:4923-4931

The human immunodeficiency virus type 1 (HIV-1) nef gene was originally described as a negative regulator of transcription from the viral long terminal repeat promoter. This observation has been disputed, and the function of Nef remains unclear. In v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e606494332e5499c1168cb4c1a090f77
https://doi.org/10.1128/jvi.67.8.4923-4931.1993

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Saliva and inhibition of HIV-1 infection: molecular mechanisms

Autor: D C, Shugars, S P, Sweet, D, Malamud, S H, Kazmi, K, Page-Shafer, S J, Challacombe

Publikováno v: Oral diseases. 8

Oral fluids are rarely a vehicle for HIV-1 infection in vivo, unlike other mucosal secretions. This unique property raises questions regarding (1) the molecular mechanisms responsible for the lack of salivary transmission, (2) the extent to which ora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::231156b5d0e2185a9967ce720ff9f5ee
https://pubmed.ncbi.nlm.nih.gov/12164652

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Inhibition of human immunodeficiency virus type 1 infectivity by secretory leukocyte protease inhibitor occurs prior to viral reverse transcription

Autor: T B, McNeely, D C, Shugars, M, Rosendahl, C, Tucker, S P, Eisenberg, S M, Wahl

Publikováno v: Blood. 90(3)

Infection of monocytes with human immunodeficiency virus type 1(Ba-L) (HIV-1(Ba-L)) is significantly inhibited by treatment with the serine protease inhibitor, secretory leukocyte protease inhibitor (SLPI). SLPI does not appear to act on virus direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca22de370f77fcc8524090446174d004
https://pubmed.ncbi.nlm.nih.gov/9242546

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Detecting, diagnosing, and preventing oral cancer

Autor: D C, Shugars, L L, Patton

Publikováno v: The Nurse practitioner. 22(6)

Unlike many other malignancies, cancers of the mouth and surrounding tissues continue to cause considerable mortality and morbidity in this country. Therefore, early detection, diagnosis, and treatment of patients with oral cancer must be a high prio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b853275930a6f71879e976d9f0b2663
https://pubmed.ncbi.nlm.nih.gov/9211456

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Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I

Autor: D C, Shugars, D L, Sauls, J B, Weinberg

Publikováno v: Oral diseases. 3

Saliva contains factors that inhibit infection with the human immunodeficiency virus type 1 (HIV-1) in vitro. One of these factors was recently identified as secretory leukocyte protease inhibitor (SLPI), a salivary protein which blocked HIV-1 infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d04e844cf13d3e495802a15f002f2dd2
https://pubmed.ncbi.nlm.nih.gov/9456661

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Inhibition of productive human immunodeficiency virus-1 infection by cobalamins

Autor: J B, Weinberg, D L, Sauls, M A, Misukonis, D C, Shugars

Publikováno v: Blood. 86(4)

Various cobalamins act as important enzyme cofactors and modulate cellular function. We investigated cobalamins for their abilities to modify productive human immunodeficiency virus-1 (HIV-1) infection of hematopoietic cells in vitro. We show that hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a82b9c20716711278eae5b8f1f7f46da
https://pubmed.ncbi.nlm.nih.gov/7632933

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