Výsledky vyhledávání - "D C Montefiori"

Akademický článek

Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

Publikováno v: npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)

Abstract The HIV-1 envelope glycoprotein (Env) trimer is the key target for vaccines aimed at inducing neutralizing antibodies (NAbs) against HIV-1. The clinical candidate immunogen ConM SOSIP.v7 is a stabilized native-like HIV-1 Env trimer based on

Externí odkaz: https://doaj.org/article/d919d26129cb4d55a6a5afbc08a9a26e

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V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120. NIH-NIAID AIDS Vaccine Clinical Trials Network

Autor: D C Montefiori, B S Graham, J Zhou, R A Bucco, D H Schwartz, L A Cavacini, M R Posner

Publikováno v: Journal of Clinical Investigation. 92:840-847

Sera from 11 volunteers immunized with a recombinant HIV-1 gp160-expressing vaccinia virus (HIVAC-1e; Oncogen/Bristol-Myers Squibb, Seattle, WA) and boosted with baculovirus-derived rgp160 (VaxSyn; MicroGeneSys, Inc., Meriden, CT) were evaluated for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a850e63fa94b70cd4e2825685d07b2df
https://doi.org/10.1172/jci116658

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Protection by SIV VLP DNA prime/protein boost following mucosal SIV challenge is markedly enhanced by IL-12/GM-CSF co-administration

Autor: E, O'Neill, I, Martinez, F, Villinger, M, Rivera, S, Gascot, C, Colon, T, Arana, M, Sidhu, R, Stout, D C, Montefiori, M, Martinez, A A, Ansari, Z R, Israel, E, Kraiselburd

Publikováno v: Journal of medical primatology. 31(4-5)

The ever increasing number of people infected by human immunodeficiency virus (HIV) throughout the world renders the development of effective vaccines an urgent priority. Herein, we report on an attempt to induce and enhance antiviral responses using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a2e0f35672f982453bf5bc1aba21a8c
https://pubmed.ncbi.nlm.nih.gov/12390544

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Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge

Autor: R, Hofmann-Lehmann, J, Vlasak, R A, Rasmussen, S, Jiang, P L, Li, T W, Baba, D C, Montefiori, B J, Bernacky, T A, Rizvi, R, Schmidt, L R, Hill, M E, Keeling, H, Katinger, G, Stiegler, L A, Cavacini, M R, Posner, R M, Ruprecht

Publikováno v: Journal of medical primatology. 31(3)

Simian-human immunodeficiency viruses (SHIV) allow the evaluation of antiviral strategies that target the envelope glycoproteins of the human immunodeficiency virus 1 (HIV-1) in macaques. We previously protected neonates from oral challenge with cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9693d2f9efd1a5e4ae4883140f8a533e
https://pubmed.ncbi.nlm.nih.gov/12190851

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DNA prime/protein boost vaccine strategy in neonatal macaques against simian human immunodeficiency virus

Autor: Robert A, Rasmussen, R, Hofmann-Lehman, D C, Montefiori, P L, Li, V, Liska, J, Vlasak, T W, Baba, J E, Schmitz, M J, Kuroda, H L, Robinson, H M, McClure, S, Lu, S L, Hu, T A, Rizvi, R M, Ruprecht

Publikováno v: Journal of medical primatology. 31(1)

Newborn macaques were vaccinated against a chimeric simian human immunodeficiency (SHIV) virus, SHIV-vpu+, by DNA priming and boosting with homologous HIV-1 gp160. Following SHIV-vpu+ challenge, containment of infection was observed in 4 of 15 animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a0c5d15359c2b0a5288f3e8d357d9f0
https://pubmed.ncbi.nlm.nih.gov/12076047

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DNA priming and recombinant pox virus boosters for an AIDS vaccine

Autor: H L, Robinson, D C, Montefiori, R P, Johnson, M L, Kalish, S L, Lydy, H M, McClure

Publikováno v: Developments in biologicals. 104

Eight different protocols for immunization have been compared for the ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62e4006584990d2c25f868b398f763b7
https://pubmed.ncbi.nlm.nih.gov/11713830

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Analysis of intercurrent human immunodeficiency virus type 1 infections in phase I and II trials of candidate AIDS vaccines. AIDS Vaccine Evaluation Group, and the Correlates of HIV Immune Protection Group

Autor: B S, Graham, M J, McElrath, R I, Connor, D H, Schwartz, G J, Gorse, M C, Keefer, M J, Mulligan, T J, Matthews, S M, Wolinsky, D C, Montefiori, S H, Vermund, J S, Lambert, L, Corey, R B, Belshe, R, Dolin, P F, Wright, B T, Korber, M C, Wolff, P E, Fast

Publikováno v: The Journal of infectious diseases. 177(2)

Among 2099 uninfected subjects in phase I and II trials of candidate AIDS vaccines, 23 were diagnosed with intercurrent human immunodeficiency virus type 1 (HIV-1) infection. High-risk sexual exposures accounted for 17 infections, and intravenous dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3eae35717f1a9d7e47373b99281b3523
https://pubmed.ncbi.nlm.nih.gov/9466516

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Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the V1/2 and V3 regions

Autor: S, Lu, R, Wyatt, J F, Richmond, F, Mustafa, S, Wang, J, Weng, D C, Montefiori, J, Sodroski, H L, Robinson

Publikováno v: AIDS research and human retroviruses. 14(2)

DNA vaccines that express the human immunodeficiency virus type 1 HXB-2 envelope glycoprotein (Env) with or without deletions of the major variable regions V1/V2 and V3 were tested for the ability to raise enzyme-linked immunosorbent assay (ELISA) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e522f458d906f75b5e204eb4098d97b8
https://pubmed.ncbi.nlm.nih.gov/9462925

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Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239delta3 in adult and infant rhesus monkeys

Autor: D C, Montefiori, T W, Baba, A, Li, M, Bilska, R M, Ruprecht

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(12)

Variants of SIV containing a deletion in the nef gene are attenuated in adult macaques, where they provide protection from challenge with pathogenic SIV, but the mechanism of protection remains unknown. One of these attenuated variants carrying delet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c59471c36e03af7de3497fff13a99214
https://pubmed.ncbi.nlm.nih.gov/8955203

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