Zobrazeno 1 - 10
of 12
pro vyhledávání: '"D C Bullard"'
Publikováno v:
The Journal of Immunology. 159:2058-2067
MRL/MpJ-Fas(lpr) (Fas(lpr)) mice develop a rapidly fatal form of systemic autoimmune disease characterized by glomerulonephritis and vasculitis similar to severe cases of systemic lupus erythematosus in humans. To evaluate the requirement for interce
Publikováno v:
The Journal of Immunology. 157:3153-3158
Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the firm adhesion of leukocytes to venular endothelium and facilitates leukocyte extravasation from the vasculature into inflamed tissue. In addition, ICAM-1 is an important costim
Autor:
S, Baldus, J P, Eiserich, A, Mani, L, Castro, M, Figueroa, P, Chumley, W, Ma, A, Tousson, C R, White, D C, Bullard, M L, Brennan, A J, Lusis, K P, Moore, B A, Freeman
Publikováno v:
The Journal of clinical investigation. 108(12)
Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil-derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this posttranslational protein modification via oxidation of ni
Autor:
C G, Kevil, D C, Bullard
Publikováno v:
Acta physiologica Scandinavica. 173(1)
Endothelial cells play a crucial role in maintaining cardiovascular homeostasis. Although many cardiovascular disorders involve endothelial cell dysfunction, the specific cellular and molecular mechanisms involved are not well known. We sought to est
Autor:
Z M, Ding, J E, Babensee, S I, Simon, H, Lu, J L, Perrard, D C, Bullard, X Y, Dai, S K, Bromley, M L, Dustin, M L, Entman, C W, Smith, C M, Ballantyne
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(9)
To differentiate the unique and overlapping functions of LFA-1 and Mac-1, LFA-1-deficient mice were developed by targeted homologous recombination in embryonic stem cells, and neutrophil function was compared in vitro and in vivo with Mac-1-deficient
Autor:
D C, Bullard, J M, Mobley, J M, Justen, L M, Sly, J G, Chosay, C J, Dunn, J R, Lindsey, A L, Beaudet, N D, Staite
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(5)
P-selectin plays an important role in leukocyte adherence to microvascular endothelium and is expressed in synovial tissue from patients with rheumatoid arthritis (RA). However, the contribution of P-selectin to the initiation and chronicity of joint
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(9)
Mutant mice triply deficient in ICAM-1, E-selectin, and P-selectin did not develop the neutrophilic skin lesions that spontaneously arise in mutants doubly deficient in E-selectin and P-selectin. Thus, ICAM-1 is essential to skin disease resulting fr
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(4)
MRL/MpJ-Fas(lpr) (Fas(lpr)) mice develop a rapidly fatal form of systemic autoimmune disease characterized by glomerulonephritis and vasculitis similar to severe cases of systemic lupus erythematosus in humans. To evaluate the requirement for interce
Autor:
C M, Doerschuk, W M, Quinlan, N A, Doyle, D C, Bullard, D, Vestweber, M L, Jones, F, Takei, P A, Ward, A L, Beaudet
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(10)
Cobra venom factor (CVF) induces lung injury through oxidant- and neutrophil-dependent mechanisms. Adhesion molecules, particularly L-selectin, P-selectin, CD11/CD18, and ICAM-1, are required for full expression of injury in rats. This study compared
Publikováno v:
Blood. 88(8)
Leukocyte rolling and emigration in response to inflammatory stimuli appears to involve both E-selectin- and P-selectin-dependent adhesion, which suggests that these molecules have overlapping functions. To clarify their relative contributions in chr