Zobrazeno 1 - 10
of 19
pro vyhledávání: '"D C Billington"'
Autor:
E, Lattmann, J, Sattayasai, P, Lattmann, D C, Billington, C H, Schwalbe, J, Boonprakob, W, Airarat, H, Singh, M, Offel, A, Staaf
Publikováno v:
Drug discoveriestherapeutics. 1(1)
Various 1,4-benzodiazepines were synthesized around a Diazepam, Oxazepam and the n-propyl-1,4-benzodiazepine template. SAR studies of CCK(2) binding affinity were performed and selected examples of each series were tested in vivo in mice. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66de868444f92dc3f6b601987f0130c4
https://pubmed.ncbi.nlm.nih.gov/22504363
https://pubmed.ncbi.nlm.nih.gov/22504363
Autor:
I. M. Mawer, D. C. Billington, R. Baker, Steven D. Young, S. J. De Solms, Joseph P. Vacca, J. J. Kulagowski, Joel R. Huff
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::730ab38d9d5119ce22c11d4af293a894
https://doi.org/10.1002/chin.199152347
https://doi.org/10.1002/chin.199152347
Publikováno v:
Drug design and discovery. 17(3)
The SAR of Asperlicin analogues is reported, leading to bioactive 1,4-benzodiazepine-2-ones, which were prepared in a 3 step reaction sequence. The Asperlicin substructure was built up using Tryptophan and readily available 2-amino-acetophenones. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1f96c412afb8887f460701dec1b15ea
https://pubmed.ncbi.nlm.nih.gov/11469752
https://pubmed.ncbi.nlm.nih.gov/11469752
Publikováno v:
Drug design and discovery. 16(3)
A three dimensional combinatorial library of 3-halogen-4-amino-5-alkoxy-2(5H)-furanones has been prepared by applying solution phase combinatorial chemistry techniques. The substituents in the 3-4-5-positions of a butenolide scaffold were varied inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ad8d04d7de05ae248ca7bd10ce36cf5
https://pubmed.ncbi.nlm.nih.gov/10624570
https://pubmed.ncbi.nlm.nih.gov/10624570
Publikováno v:
Drug design and discovery. 16(3)
Starting from furfural, 5-hydroxy-3,4-dihalo-2(5H)-furanones and 5-hydroxy-4 chloro-2(5H)-furanone were converted into 3 sublibraries of halogenated 5-alkoxy-2(5H)-furanones. The reactivity of 24 halogenated 5-alkoxy2(5H)-furanones was chemically eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e6e1f085186a3f8a7b09b5839446de5
https://pubmed.ncbi.nlm.nih.gov/10624569
https://pubmed.ncbi.nlm.nih.gov/10624569
Publikováno v:
Drug design and discovery. 16(3)
Knowledge and Knowledge Management are becoming common senior management parlance in the Pharmaceutical Industry in the late 1990s. This perspective article will address exactly what is knowledge and the various techniques available to harness and us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cecd8afc6e797c30d791e13889f9b739
https://pubmed.ncbi.nlm.nih.gov/10624564
https://pubmed.ncbi.nlm.nih.gov/10624564
Autor:
S, Augy-Dorey, D C, Billington, J A, Camara, S D, Gero, I, Sagnard, B, Quiclet-Sire, D, Ghezzi
Publikováno v:
Drug design and discovery. 16(1)
We have synthesised a number of analogues of lipid X, a precursor in the biosynthesis of LPS, some of which exhibit marked antagonism of LPS induced TNF production in vivo. These compounds provide new non-polar leads in the search for a therapy for e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7cbbfb4d91e38e8c9e7b7fc1242fb524
https://pubmed.ncbi.nlm.nih.gov/10466055
https://pubmed.ncbi.nlm.nih.gov/10466055
Autor:
D C, Billington
Publikováno v:
Drug design and discovery. 8(1)
To summarise the key points: The ability to mount an angiogenic response is probably present in all tissues, and stimulation of endothelial cells by any one of a wide variety of factors initiates a cascade of events leading to angiogenesis. In most t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dec8434312768b14a734b82a089146b2
https://pubmed.ncbi.nlm.nih.gov/1725722
https://pubmed.ncbi.nlm.nih.gov/1725722
Autor:
Michael Offel, Pornthip Lattmann, Harjit Singh, D. C. Billington, Yodchai Bunprakob, Jintana Sattayasai
Publikováno v:
Archiv der Pharmazie; Apr2006, Vol. 339 Issue 4, p163-173, 11p