Výsledky vyhledávání

Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2

Autor: D N Garboczi, U Utz, P Ghosh, A Seth, J Kim, E A VanTienhoven, W E Biddison, D C Wiley

Publikováno v: The Journal of Immunology. 157:5403-5410

T lymphocytes use TCR-alphabeta to bind and to recognize complexes of antigenic peptides bound to MHC proteins located at the surface of APCs. We have assembled and crystallized this intercellular complex of TCR/peptide/MHC from soluble human TCR-alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a484674e03b518be7de846f184a640b
https://doi.org/10.4049/jimmunol.157.12.5403

Zobrazit plný text záznamu

alpha beta T cell receptor ligand-specific oligomerization revisited

Autor: B M, Baker, D C, Wiley

Publikováno v: Immunity. 14(6)

The mechanism of T cell receptor signaling is unclear. Included among models for TCR signaling is ligand-induced oligomerization in a fashion analogous to other cell surface receptors. Published kinetic, saturation binding, and light scattering exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::591ade8fd4bae6f5a796bad27442c6ca
https://pubmed.ncbi.nlm.nih.gov/11420037

Zobrazit plný text záznamu

Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling

Autor: B M, Baker, S J, Gagnon, W E, Biddison, D C, Wiley

Publikováno v: Immunity. 13(4)

The structure of the A6 alphabetaTCR/HTLV-1 Tax-peptide/MHC I complex with proline 6 of Tax substituted with alanine (P6A), an antagonist, is nearly identical to the structure with wild-type Tax agonist. Neither the proline in the agonist nor the ala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da6215578d450394528ec1e0588e0ef4
https://pubmed.ncbi.nlm.nih.gov/11070166

Zobrazit plný text záznamu

A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer

Autor: Q R, Fan, E O, Long, D C, Wiley

Publikováno v: European journal of immunology. 30(9)

Inhibitory receptors on the surface of natural killer (NK) cells recognize specific MHC class I molecules on target cells and prevent the target cell lysis by NK cells. The killer cell immunoglobulin-related receptors (KIR), KIR2D, found in human, sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ba597e744e39303f9bb6905697dff34
https://pubmed.ncbi.nlm.nih.gov/11009104

Zobrazit plný text záznamu

Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

Autor: M, Ferrer, T M, Kapoor, T, Strassmaier, W, Weissenhorn, J J, Skehel, D, Oprian, S L, Schreiber, D C, Wiley, S C, Harrison

Publikováno v: Nature structural biology. 6(10)

The trimeric, alpha-helical coiled-coil core of the HIV-1 gp41 ectodomain is thought to be part of a transient, receptor-triggered intermediate in the refolding of the envelope glycoprotein into a fusion-active conformation. In an effort to discover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b7d5112f5fe3396b54dcbdb2392fe1e
https://pubmed.ncbi.nlm.nih.gov/10542088

Zobrazit plný text záznamu

Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures

Autor: S, Hausmann, W E, Biddison, K J, Smith, Y H, Ding, D N, Garboczi, U, Utz, D C, Wiley, K W, Wucherpfennig

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(9)

The crystal structures of two human TCRs specific for a HTLV-I Tax peptide bound to HLA-A2 were recently determined, for the first time allowing a functional comparison of TCRs for which the MHC/peptide/TCR structures are known. Extensive amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85c24aede56d726af9b594ce96b42857
https://pubmed.ncbi.nlm.nih.gov/10228016

Zobrazit plný text záznamu

Crystal structures of HLA-A*0201 complexed with antigenic peptides with either the amino- or carboxyl-terminal group substituted by a methyl group

Autor: M, Bouvier, H C, Guo, K J, Smith, D C, Wiley

Publikováno v: Proteins. 33(1)

The crystal structures of class I major histocompatibility complex (MHC) molecules complexed with antigenic peptides revealed a network of hydrogen bonds between the charged amino- and carboxyl-termini of the peptides and conserved MHC residues at bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::890e7e941f8cadb8e0d599c04e7579a6
https://pubmed.ncbi.nlm.nih.gov/9741848

Zobrazit plný text záznamu

Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2

Autor: D N, Garboczi, U, Utz, P, Ghosh, A, Seth, J, Kim, E A, VanTienhoven, W E, Biddison, D C, Wiley

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76f326956fe416ce5adea8c2b07a9409
https://pubmed.ncbi.nlm.nih.gov/8955188

Zobrazit plný text záznamu

The ectodomain of HIV-1 env subunit gp41 forms a soluble, alpha-helical, rod-like oligomer in the absence of gp120 and the N-terminal fusion peptide

Autor: W, Weissenhorn, S A, Wharton, L J, Calder, P L, Earl, B, Moss, E, Aliprandis, J J, Skehel, D C, Wiley

Publikováno v: The EMBO journal. 15(7)

The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein is composed of a soluble glycopolypeptide gp120 and a transmembrane glycopolypeptide gp41. These subunits form non-covalently linked oligomers on the surface of infected cells, virions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e419ce34bd438e216d815d46427eb7cd
https://pubmed.ncbi.nlm.nih.gov/8612573

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání