Zobrazeno 1 - 10 of 147 pro vyhledávání: '"D C, Warhurst"'
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Akademický článek
Detecção da mutação dupla 86TYR e 1246TYR no gene pfmdr1 em clones de uma amostra de Plasmodium falciparum da África Ocidental, resistente à cloroquina.
Autor: L Pinheiro, S Franco, I S Adagu, R Rosa, V E Rosário, D C Warhurst
Publikováno v: Acta Médica Portuguesa, Vol 16, Iss 4 (2003)
Isolates of Plasmodium falciparum from three areas of West Africa were recovered from cryopreservation and their chloroquine-sensitivity were determined in vitro. Of the 90 samples studied, 60 were from Guinea-Bissau (30Resistant/30Sensitive), 15 wer
Externí odkaz: https://doaj.org/article/ba47d0367bd140afb7252bed5afa32fb
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3
Bioactive Compounds from Celaenodendron mexicanum
Autor: M. del Rayo Camacho, D. C. Warhurst, Rachel Mata, J. D. Phillipson, G. C. Kirby, Perla Castañeda, Simon L. Croft
Publikováno v: Planta Medica. 66:463-468
Bioactivity-directed fractionation of the CHCl3-MeOH extract of the leaves of Celaenodendron mexicanum by means of the brine shrimp lethality test and chromatographic techniques led to the isolation of three carboxylic acid triterpenes, the new tiruc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e6bf0371aba539e1383802eb2b5369
https://doi.org/10.1055/s-2000-8598
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4
Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study
Autor: L von Seidlein, D. C. Warhurst, Margaret Pinder, I Sambou, P Jones, Manoj T. Duraisingh
Publikováno v: Parasitology. 119:435-440
Artemisinin (QHS) and its derivatives are new antimalarials which are effective against Plasmodium falciparum parasites resistant to chloroquine (CQ). As these drugs are introduced it is imperative that resistance is monitored. In this paper we demon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bb4d55b0c9b0b2567a987f0a6e4506
https://doi.org/10.1017/s0031182099004953
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5
Allele-specific, nested, one tube PCR: application to Pfmdr1 polymorphisms in Plasmodium falciparum
Autor: D. C. Warhurst, I.S. Adagu
Publikováno v: Parasitology. 119:1-6
An allele-specific, one tube PCR for the sensitive and reliable detection of point mutations in Plasmodium falciparum DNA is described. Design of specific internal primers and optimization of the PCR is simple, and the procedure is robust and sensiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c152fba4680e4b121ac167d51e710fa
https://doi.org/10.1017/s0031182099004382
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6
Drug resistance inPlasmodium falciparum malaria
Autor: D C Warhurst
Publikováno v: Infection. 27:S55-S58
Four classes of drugs are reviewed: blood schizontocides acting only on the hemoglobin-digesting blood stages, the antifolates which attack tetrahydrofolate synthesis in all the growing stages, antimitochondrials affecting synthesis and electron tran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8474472bec94fd52b6b91bb5cf61ed7
https://doi.org/10.1007/bf02561674
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7
Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania
Autor: T. Jelinek, A. M. Rønn, M. M. Lemnge, J. Curtis, J. Mhina, M. T. Duraisingh, I. C. Bygbjerg, D. C. Warhurst
Publikováno v: Tropical Medicine & International Health. 3:605-609
The efficacy of sulphadoxine/pyrimethamine (S/P) in treatment of uncomplicated falciparum malaria in Africa is increasingly compromised by development of resistance. The occurrence of mutations associated with the active site sequence in the Plasmodi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361a72dd0f47f10dc02d9954fa172961
https://doi.org/10.1046/j.1365-3156.1998.00280.x
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9
In vitro andin vivo antimalarial activity of cryptolepine, a plant-derived indoloquinoline
Autor: B. K. Noamese, G. C. Kirby, D. C. Warhurst, A. Paine, J. D. Phillipson
Publikováno v: Phytotherapy Research. 9:359-363
Cryptolepine is an indoloquinoline, high yields of which may be extracted from the roots of the West African shrub Cryptolepis sanguinolenta. The use of this plant as a traditional treatment for malaria is widespread in Ghana and is reported to be cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efbbbe408252f9f3d5976ad03420b6ff
https://doi.org/10.1002/ptr.2650090510
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10
[Presence of the double pfmdr1 mutation 86Tyr and 1246 Tyr in clones of a chloroquine-resistant west African isolate of Plasmodium falciparum]
Autor: L, Pinheiro, S, Franco, I S, Adagu, R, Rosa, V E, Rosário, D C, Warhurst
Publikováno v: Acta medica portuguesa. 16(4)
Isolates of Plasmodium falciparum from three areas of West Africa were recovered from cryopreservation and their chloroquine-sensitivity were determined in vitro. Of the 90 samples studied, 60 were from Guinea-Bissau (30Resistant/30Sensitive), 15 wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8646226d5ea6c8ea3af3919c42c3e4f1
https://pubmed.ncbi.nlm.nih.gov/22226207
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