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Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys

Autor: L J, Benincosa, F S, Chow, L P, Tobia, D C, Kwok, C B, Davis, W J, Jusko

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(2)

The pharmacokinetics and pharmacodynamics (PK/PD) of a humanized anti-Factor IX IgG1 monoclonal antibody (SB 249417, FIX mAb) were studied in Cynomolgus monkeys. Single i.v. bolus doses of 1, 3, or 10 mg/kg of FIX mAb were administered. The total FIX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a51fd73d0016675e0b344bb67d4d285
https://pubmed.ncbi.nlm.nih.gov/10640322

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Disposition of metabolically radiolabeled CE9.1--a macaque-human chimeric anti-human CD4 monoclonal antibody--in transgenic mice bearing human CD4

Autor: C B, Davis, E M, Garver, D C, Kwok, J J, Urbanski

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 24(9)

IDEC-CE9.1 is a macaque/human chimeric IgG1 monoclonal antibody (mAb) directed against the human T-lymphocyte receptor, CD4. CE9.1 is highly specific for the human receptor and is known to cross-react only with chimpanzee CD4. Thus, limited in vivo i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::605e7b85f48dc3a59a996a661b6f343c
https://pubmed.ncbi.nlm.nih.gov/8886616

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Preclinical pharmacokinetic evaluation of the respiratory syncytial virus-specific reshaped human monoclonal antibody RSHZ19

Autor: C B, Davis, T W, Hepburn, J J, Urbanski, D C, Kwok, T K, Hart, D J, Herzyk, S G, Demuth, M, Leland, G R, Rhodes

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(10)

A preclinical evaluation of RSHZ19, a respiratory syncytial virus-specific reshaped human monoclonal antibody (IgG1 framework), has included pharmacokinetic studies in rats, adult cynomolgus macaques, and infant baboons after intravenous (iv), subcut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73179b3f18f71e25ca7c10a18bb2717f
https://pubmed.ncbi.nlm.nih.gov/8654189

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A retrospective study of Moore and Thompson hemiarthroplasty. A review of 599 surgical cases and an analysis of the technical complications

Autor: D C, Kwok, R L, Cruess

Publikováno v: Clinical orthopaedics and related research. (169)

In a retrospective review of 580 patients with 599 hemiarthroplasties of the hip, 454 operations (75.8%) were carried out as primary procedures for fresh intracapsular fractures, and 145 operations (24.2%) were performed as salvage procedures. The th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aaf8bd95fdebb3a5cc4aa1950750c6ef
https://pubmed.ncbi.nlm.nih.gov/7105576

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