Zobrazeno 1 - 10
of 80
pro vyhledávání: '"D C, Argentieri"'
Autor:
Fred W. Quimby, D C Argentieri, Robert J. Capetola, Ariel L. Rivas, David W. Anderson, Michael G. Goodman, Edward S. Kimball, Linda Tintle
Publikováno v:
Clinical Immunology and Immunopathology. 74:243-251
A multiple immunodeficiency, involving antibody- and cell-mediated responses in 10 Chinese Shar-Pei (CSP) dogs is described. Abnormal levels of serum IgM and IgA in most cases, and IgG in fewer cases characterized the immunoglobulin deficiencies. Dec
Autor:
L. E. Burr, Erika Chourmouzis, Michael G. Goodman, D C Argentieri, Dieter H. Klaubert, Stanley C Bell, J. Come, B L Pope, J H Goodman, A B Reitz
Publikováno v:
Journal of Medicinal Chemistry. 37:3561-3578
A series of 7,8-disubstituted guanosine derivatives was designed and prepared as potential B-cell-selective activators of the humoral immune response. These compounds were evaluated for their ability to act as B-cell mitogens and to augment the antib
Autor:
D. C. Argentieri, R. J. Capetola, A. M. Kasper, David M. Ritchie, M. P. Wachter, William V. Murray
Publikováno v:
ChemInform. 22
A series of novel 6-(6-alkoxy-2-naphthyl)oxoalkanoates and alkanamides were synthesized as inhibitors of inflammation and 5-lipoxygenase. They were evaluated in vivo for anti-inflammatory activity in the established adjuvent arthritis assay in rats a
Autor:
Marianne S. Rampulla, Barbara L. Pope, D C Argentieri, Reitz Allen B, Stanley C. Bell, Dieter H. Klaubert, Robert Chen, Mary R. Schott, L. E. Burr, Michael G. Goodman, Bruce E. Maryanoff, J H Goodman, J. Come
Publikováno v:
ChemInform. 26
7-Allyl-8-oxoguanosine (loxoribine, 5) was selected from a series of guanosine derivatives for further evaluation as an immunostimulant. Numerous related analogs were also synthesized and evaluated: 2′,3′-ketals of 5 are particularly interesting
Publikováno v:
Thrombosis and haemostasis. 86(5)
The response to vascular injury is a complex wound healing response involving cell proliferation, migration, remodeling and inflammation. In the present studies we employed a rat balloon angioplasty model of vascular injury to investigate the potenti
Publikováno v:
Methods in enzymology. 311
Autor:
T, Kirchner, D C, Argentieri, A G, Barbone, M, Singer, M, Steber, J, Ansell, S A, Beers, M P, Wachter, W, Wu, E, Malloy, A, Stewart, D M, Ritchie
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(2)
Sterile perforated polyethylene spheres (wiffle golf balls) were implanted s.c. in beagle dogs. A local inflammatory reaction was elicited within the spheres by injecting carrageenan. Changes in leukocyte count, prostaglandin E2, thromboxane B2 and l
Publikováno v:
Prostaglandins, leukotrienes, and essential fatty acids. 56(6)
Prostaglandins and thromboxanes are products of arachidonic acid metabolism via the cyclooxygenase (CO) enzyme and are responsible for the pain and swelling common to sites of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the p
Autor:
David W. Anderson, Robert J. Capetola, Carla Cicala, D C Argentieri, Giuseppe Cirino, John L. Wallace
Publikováno v:
Agents and actions. 34(1-2)
The ability of tepoxalin to render the gastric mucosa susceptible to injury by a topically applied irritant was compared to that of indomethacin, naproxen and diclofenac. While the three NSAIDs significantly increased the extent of mucosal damage at
Autor:
L B, Katz, R J, Capetola, D C, Argentieri, L E, Moore, T, Genna, M C, Porter, V, Jasty, R E, Hartnagel, D, Abrutyn, D A, Shriver
Publikováno v:
The Journal of rheumatology. 13(5)
Gastrointestinal irritation is the most significant side effect in patients chronically taking nonsteroidal antiinflammatory drugs (NSAID) for treatment of arthritic conditions. Rioprostil, a primary alcohol prostaglandin E1 analog, prevents gastric