Inter-kingdom relationships in Crohn’s disease explored using a multi-omics approach

Autor: Alessandra Frau, Umer Z. Ijaz, Rachael Slater, Daisy Jonkers, John Penders, Barry J. Campbell, John G. Kenny, Neil Hall, Luca Lenzi, Michael D. Burkitt, Marieke Pierik, Alistair C. Darby, Christopher S. J. Probert

Publikováno v: Gut Microbes, Vol 13, Iss 1 (2021)

The etiology of Crohn’s disease (CD) is multifactorial. Bacterial and fungal microbiota are involved in the onset and/or progression of the disease. A bacterial dysbiosis in CD patients is accepted; however, less is known about the mycobiome and th

Externí odkaz: https://doaj.org/article/a5136c0e2fd0425fa3c6145f461cf2a1

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models

Autor: Michael D. Burkitt, Carrie A. Duckworth, Jonathan M. Williams, D. Mark Pritchard

Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 2, Pp 89-104 (2017)

Gastric colonization with Helicobacter pylori induces diverse human pathological conditions, including superficial gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma and its precursors. The

Externí odkaz: https://doaj.org/article/1a40e16da9c7444dae4e3d63f7baa544

Oral iron exacerbates colitis and influences the intestinal microbiome.

Autor: Awad Mahalhal, Jonathan M Williams, Sophie Johnson, Nicholas Ellaby, Carrie A Duckworth, Michael D Burkitt, Xuan Liu, Georgina L Hold, Barry J Campbell, D Mark Pritchard, Chris S Probert

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0202460 (2018)

Inflammatory bowel disease (IBD) is associated with anaemia and oral iron replacement to correct this can be problematic, intensifying inflammation and tissue damage. The intestinal microbiota also plays a key role in the pathogenesis of IBD, and iro

Externí odkaz: https://doaj.org/article/094faab6a3de4bcb8cd37152c6ce50f2

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide

Autor: Jonathan M. Williams, Carrie A. Duckworth, Alastair J. M. Watson, Mark R. Frey, Jennifer C. Miguel, Michael D. Burkitt, Robert Sutton, Kevin R. Hughes, Lindsay J. Hall, Jorge H. Caamaño, Barry J. Campbell, D. Mark Pritchard

Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 6, Pp 1388-1399 (2013)

SUMMARY The gut barrier, composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, prevents the entrance of harmful microorganisms, antigens and toxins from the gut lumen into the blood. Small intestinal homeo

Externí odkaz: https://doaj.org/article/4630f77e6fe944868eef1669ad069a9d

Netazepide inhibits expression of Pappalysin 2 in type-1 gastric neuroendocrine tumors

Autor: Andrea Varro, Carrie A. Duckworth, Katie A. Lloyd, Yongxiang Fang, Stamatia Papoutsopoulou, Nathan Howes, Klaire Exarchou, Lucille Rainbow, Andrew R. Moore, D. Mark Pritchard, Neil Hall, Claus Oxvig, Michael D. Burkitt, Steven Dodd, Bryony N. Parsons, Malcolm Boyce

Publikováno v: Lloyd, K A, Parsons, B N, Burkitt, M D, Moore, A R, Papoutsopoulou, S, Boyce, M, Duckworth, C A, Exarchou, K, Howes, N, Rainbow, L, Fang, Y, Oxvig, C, Dodd, S, Varro, A, Hall, N & Pritchard, D M 2020, ' Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors ', Cellular and Molecular Gastroenterology and Hepatology, vol. 10, no. 1, pp. 113-132 . https://doi.org/10.1016/j.jcmgh.2020.01.010
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 113-132 (2020)

Background & Aims In patients with autoimmune atrophic gastritis and achlorhydria, hypergastrinemia is associated with the development of type 1 gastric neuroendocrine tumors (gNETs). Twelve months of treatment with netazepide (YF476), an antagonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7554914bc0596db17395b9f59dbcfa2f
https://ueaeprints.uea.ac.uk/id/eprint/73860/