Zobrazeno 1 - 10
of 74
pro vyhledávání: '"D Bruce Fulton"'
Publikováno v:
eLife, Vol 9 (2020)
Bruton’s tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including leukemias and lymphomas. Currently approved BTK inhibitors, including Ibrutinib, a first-in-class covalent inhibitor of BTK, bind directly to the kinase activ
Externí odkaz:
https://doaj.org/article/a1e7c59bd7424b1ea7e5693fd82af544
Autor:
John R. Engen, Wayland Yeung, Amy H. Andreotti, Natarajan Kannan, Raji E. Joseph, Thomas E. Wales, Annie Kwon, Neha Amatya, D. Bruce Fulton
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Bruton’s tyrosine kinase (BTK) is targeted in treatment of immune cancers. As patients experience drug resistance, there is a need for alternative approaches to inhibit BTK. Other recently published findings clarify the role of the BTK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b46e9736548b9bb59758a0fad5a17c6
https://doi.org/10.1073/pnas.1907566116
https://doi.org/10.1073/pnas.1907566116
Autor:
Vibeke Sundvold-Gjerstad, Stine Granum, Anne Spurkland, Thorny Cecilie Bie Andersen, B. Göran Karlsson, Morten Sørli, Amy H. Andreotti, Paul Hoff Backe, Per Eugen Kristiansen, Maria U. Johansson, D. Bruce Fulton, Zsuzsa Huszenicza, Hanna Kjelstrup, Ramakrishna Prabhu Gopalakrishnan, Scott E. Boyken
Publikováno v:
Journal of Biological Chemistry
J Biol Chem
15480-15494
J Biol Chem
15480-15494
T-cell activation requires stimulation of specific intracellular signaling pathways in which protein-tyrosine kinases, phosphatases, and adapter proteins interact to transmit signals from the T-cell receptor to the nucleus. Interactions of LCK proto-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cfc7a81c034588204a3cbfa7ade9bf
Autor:
Raji E. Joseph, Jacques Lowe, D. Bruce Fulton, John R. Engen, Thomas E. Wales, Amy H. Andreotti
Publikováno v:
J Mol Biol
Mutations in PLCγ, a substrate of the tyrosine kinase BTK, are often found in patients who develop resistance to the BTK inhibitor Ibrutinib. However, the mechanisms by which these PLCγ mutations cause Ibrutinib resistance are unclear. Under normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9710c8ad59f2d3eb252cc31ce8c5b04
https://doi.org/10.1016/j.jmb.2021.167422
https://doi.org/10.1016/j.jmb.2021.167422
Autor:
D. Bruce Fulton, Amy H. Andreotti, Thomas E. Wales, Neha Amatya, John R. Engen, Raji E. Joseph
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Bruton’s tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including leukemias and lymphomas. Currently approved BTK inhibitors, including Ibrutinib, a first-in-class covalent inhibitor of BTK, bind directly to the kinase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875a24ef2cb24a958e44ecdc63b3a2f6
https://elifesciences.org/articles/60470
https://elifesciences.org/articles/60470
Publikováno v:
Biochemistry. 56:2938-2949
Pleckstrin homology (PH) domains are well-known as phospholipid binding modules, yet evidence that PH domain function extends beyond lipid recognition is mounting. In this work, we characterize a protein binding function for the PH domain of interleu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00c60de5ac0b2e453a59da998ea01b4a
https://doi.org/10.1021/acs.biochem.6b01182
https://doi.org/10.1021/acs.biochem.6b01182
Autor:
Jagannathan Alagurajan, Mark S. Hargrove, Navjot Singh Athwal, Amy H. Andreotti, Ryan Sturms, D. Bruce Fulton
Publikováno v:
Journal of Inorganic Biochemistry. 150:139-147
Hemoglobins (phytoglobins) from rice plants (nsHb1) and from the cyanobacterium Synechocystis (PCC 6803) (SynHb) can reduce hydroxylamine with two electrons to form ammonium. The reaction requires intermolecular electron transfer between protein mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606792250acaadc4e56a47c78c4a26bc
https://doi.org/10.1016/j.jinorgbio.2015.06.014
https://doi.org/10.1016/j.jinorgbio.2015.06.014
Summary Capturing the functionally relevant forms of dynamic, multidomain proteins is extremely challenging. Bruton's tyrosine kinase (BTK), a kinase essential for B and mast cell function, has stubbornly resisted crystallization in its full-length f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3edbd65b5cf1100d99130d2c9e940b
https://europepmc.org/articles/PMC5629114/
https://europepmc.org/articles/PMC5629114/
Autor:
Scott E. Boyken, Amy H. Andreotti, Nikita Chopra, John R. Engen, Qian Xie, Raji E. Joseph, Thomas E. Wales, D. Bruce Fulton, Robert L. Jernigan
Publikováno v:
Journal of Molecular Biology. 426:3656-3669
Despite high level of homology among non-receptor tyrosine kinases, different kinase families employ a diverse array of regulatory mechanisms. For example, the catalytic kinase domains of the Tec family kinases are inactive without assembly of the ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb32e8f7b70363654cbfe1244c9e6d1
https://doi.org/10.1016/j.jmb.2014.08.018
https://doi.org/10.1016/j.jmb.2014.08.018