10.01 Prostanoid-insensitive chimeric antigen receptor modified T cells mediate therapeutic efficacy in solid cancer models

Autor: J Dorr, S Stock, S Kobold, S Michaelides, S Lesch, A Gottschlich, A Öner, D Briukhovetska, L Fertig, L Gregor, SB Lacher, L Majed, E Carlini, D Andreu Sanz, JP Böttcher

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss Suppl 1 (2024)

Externí odkaz: https://doaj.org/article/5bca9a124d554104995ea8ed823eb445

P09.01 Single-cell transcriptomic atlas-guided development of chimeric antigen-receptor (CAR) T cells for the treatment of acute myeloid leukemia

Autor: A Gottschlich, M Thomas, R Grünmeier, S Lesch, L Rohrbacher, V Igl, D Briukhovetska, M Benmebarek, S Dede, K Müller, T Xu, D Dhoqina, Ö Umut, F Märkl, S Robinson, A Sendelhofert, H Schulz, B Vick, BL Cadilha, R Brabenec, N Röder, F Rataj, M Nüesch, J Wellbrock, F Modemann, W Fiedler, C Kellner, T Herold, D Paquet, I Jeremias, L von Baumgarten, S Endres, M Subklewe, C Marr, S Kobold

Publikováno v: Poster Presentations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fa78b37cabb3e9e78e8f6cfb8e35077
https://doi.org/10.1136/jitc-2022-itoc9.57

The Spectrum of CAR Cellular Effectors: Modes of Action in Anti-Tumor Immunity.

Autor: Nguyen NTT; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, 80336 Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, a Partnership between the DKFZ Heidelberg and the University Hospital of the LMU, 80336 Munich, Germany., Müller R; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, 80336 Munich, Germany., Briukhovetska D; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, 80336 Munich, Germany., Weber J; Department of Medicine II, Chair in Cellular Immunotherapy, University Hospital Würzburg, 97080 Würzburg, Germany., Feucht J; Cluster of Excellence iFIT 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tuebingen, Germany.; Department of Hematology and Oncology, University Children's Hospital Tuebingen, University of Tübingen, 72076 Tuebingen, Germany., Künkele A; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353 Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, 10117 Berlin, Germany., Hudecek M; Department of Medicine II, Chair in Cellular Immunotherapy, University Hospital Würzburg, 97080 Würzburg, Germany.; Fraunhofer Institute for Cell Therapy and Immunology, Cellular Immunotherapy Branch Site Würzburg, 97080 Würzburg, Germany., Kobold S; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, 80336 Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, a Partnership between the DKFZ Heidelberg and the University Hospital of the LMU, 80336 Munich, Germany.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München-German Research Center for Environmental Health Neuherberg, 85764 Oberschleißheim, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2024 Jul 22; Vol. 16 (14). Date of Electronic Publication: 2024 Jul 22.

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia.

Autor: Gottschlich A; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany., Thomas M; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany., Grünmeier R; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Lesch S; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Rohrbacher L; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany., Igl V; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Briukhovetska D; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Benmebarek MR; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Munich, German Research Center for Environmental Health (HMGU), Munich, Germany.; Department of Pediatrics, University Hospital, LMU Munich, Munich, Germany., Dede S; Department of Neurology, University Hospital, LMU Munich, Munich, Germany., Müller K; Department of Neurology, University Hospital, LMU Munich, Munich, Germany., Xu T; Department of Neurology, University Hospital, LMU Munich, Munich, Germany., Dhoqina D; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Märkl F; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Robinson S; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Sendelhofert A; Institute of Pathology, LMU Munich, Munich, Germany., Schulz H; Institute of Pathology, LMU Munich, Munich, Germany., Umut Ö; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Kavaka V; Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Martinsried, Germany., Tsiverioti CA; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Carlini E; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Nandi S; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Strzalkowski T; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Lorenzini T; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Stock S; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Müller PJ; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Dörr J; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Seifert M; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Cadilha BL; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Brabenec R; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany., Röder N; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Rataj F; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Nüesch M; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Modemann F; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg, Hamburg, Germany., Wellbrock J; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Fiedler W; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kellner C; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, LMU Munich, Munich, Germany., Beltrán E; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Martinsried, Germany., Herold T; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Paquet D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Munich, German Research Center for Environmental Health (HMGU), Munich, Germany.; Department of Pediatrics, University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., von Baumgarten L; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Department of Neurosurgery, LMU Munich, Munich, Germany., Endres S; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Munich, Research Center for Environmental Health (HMGU), Neuherberg, Germany., Subklewe M; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Marr C; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany., Kobold S; Division of Clinical Pharmacology, University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany. sebastian.kobold@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. sebastian.kobold@med.uni-muenchen.de.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Munich, Research Center for Environmental Health (HMGU), Neuherberg, Germany. sebastian.kobold@med.uni-muenchen.de.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2023 Nov; Vol. 41 (11), pp. 1618-1632. Date of Electronic Publication: 2023 Mar 13.

Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma.

Autor: Märkl F; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Benmebarek MR; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Keyl J; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Cadilha BL; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Geiger M; Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Schlieren, Switzerland., Karches C; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Obeck H; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Schwerdtfeger M; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Michaelides S; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Briukhovetska D; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Stock S; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany.; Department of Medicine III, Klinikum der Universität München, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Jobst J; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Müller PJ; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Majed L; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Seifert M; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Klüver AK; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Lorenzini T; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Grünmeier R; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Thomas M; Institute of AI for Health, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Computational Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Freising, Germany., Gottschlich A; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Klaus R; Division of Pediatric Nephrology, Department of Pediatrics, Dr. v. Haunersches Kinderspital, Klinikum der Universität München, Munich, Germany., Marr C; Institute of AI for Health, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Computational Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., von Bergwelt-Baildon M; Department of Medicine III, Klinikum der Universität München, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Rothenfusser S; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Levesque MP; Department of Dermatology, University Hospital Zurich, Schlieren, Switzerland., Heppt MV; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Endres S; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Klein C; Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Schlieren, Switzerland., Kobold S; Department of Medicine IV, Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany sebastian.kobold@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2023 May; Vol. 11 (5).