Zobrazeno 1 - 10
of 123
pro vyhledávání: '"D Borden Lacy"'
Autor:
Kateryna Nabukhotna, Shannon L Kordus, John A Shupe, Rubén Cano Rodríguez, Anna Smith, Julia K Bohannon, M Kay Washington, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 20, Iss 9, p e1012568 (2024)
Clostridioides difficile is a spore-forming pathogen and the most common cause of healthcare-associated diarrhea and colitis in the United States. Besides producing the main virulence factors, toxin A (TcdA) and toxin B (TcdB), many of the common cli
Externí odkaz:
https://doaj.org/article/e4b4bb5a738b4efeab523e61d2c2ba67
Autor:
Shannon L Kordus, Heather K Kroh, Rubén Cano Rodríguez, Rebecca A Shrem, F Christopher Peritore-Galve, John A Shupe, Brian E Wadzinski, D Borden Lacy, Benjamin W Spiller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011496 (2023)
Clostridioides difficile is a leading cause of antibiotic-associated diarrhea and nosocomial infection in the United States. The symptoms of C. difficile infection (CDI) are associated with the production of two homologous protein toxins, TcdA and Tc
Externí odkaz:
https://doaj.org/article/5c0a09492fa445118a189e4830bc1d37
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010997 (2022)
Human infections caused by the toxin-producing, anaerobic and spore-forming bacterium Paeniclostridium sordellii are associated with a treatment-refractory toxic shock syndrome (TSS). Reproductive-age women are at increased risk for P. sordellii infe
Externí odkaz:
https://doaj.org/article/2bfbe9fe9d534ffa87f0b64d827118d6
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010720 (2022)
Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector proteins into a wide range of target cells. The components of T4SSs in gram-negative bacteri
Externí odkaz:
https://doaj.org/article/5f1b0c4e0e2e44808f1e742f81f9e4a2
Autor:
F Christopher Peritore-Galve, John A Shupe, Rory J Cave, Kevin O Childress, M Kay Washington, Sarah A Kuehne, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010323 (2022)
Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. In addition to these symptoms, patients with CDI can develop severe inflammation and tissue damage, resulting in life-threat
Externí odkaz:
https://doaj.org/article/53681cccf54a48f9aac596fac3673cfc
Autor:
Michael J Sheedlo, Jeong Min Chung, Neha Sawhney, Clarissa L Durie, Timothy L Cover, Melanie D Ohi, D Borden Lacy
Publikováno v:
eLife, Vol 9 (2020)
The pathogenesis of Helicobacter pylori-associated gastric cancer is dependent on delivery of CagA into host cells through a type IV secretion system (T4SS). The H. pylori Cag T4SS includes a large membrane-spanning core complex containing five prote
Externí odkaz:
https://doaj.org/article/1dde8d85688348948d757c443b00197a
Autor:
Clarissa L Durie, Michael J Sheedlo, Jeong Min Chung, Brenda G Byrne, Min Su, Thomas Knight, Michele Swanson, D Borden Lacy, Melanie D Ohi
Publikováno v:
eLife, Vol 9 (2020)
Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia Legionnaires’ Disease. This infection and subsequent pathology require the Dot/Icm Type IV Secretion System (T4SS) to deliver effector proteins into hos
Externí odkaz:
https://doaj.org/article/4e727e751c3643ba8cf52314be90d2c1
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006070 (2016)
Clostridium difficile infection affects a significant number of hospitalized patients in the United States. Two homologous exotoxins, TcdA and TcdB, are the major virulence factors in C. difficile pathogenesis. The toxins are glucosyltransferases tha
Externí odkaz:
https://doaj.org/article/67f1f3ec03564646b03be7b037d92564
Autor:
Nicole M Chumbler, Melissa A Farrow, Lynne A Lapierre, Jeffrey L Franklin, David B Haslam, James R Goldenring, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1003072 (2012)
Clostridium difficile is the most common cause of antibiotic-associated nosocomial infection in the United States. C. difficile secretes two homologous toxins, TcdA and TcdB, which are responsible for the symptoms of C. difficile associated disease.
Externí odkaz:
https://doaj.org/article/55dc2988305d4c528c22204846810d6e
Publikováno v:
PLoS Pathogens, Vol 4, Iss 12, p e1000245 (2008)
Clostridium botulinum neurotoxin (BoNT) causes flaccid paralysis by disabling synaptic exocytosis. Intoxication requires the tri-modular protein to undergo conformational changes in response to pH and redox gradients across endosomes, leading to the
Externí odkaz:
https://doaj.org/article/dc8dbb1632d54f40a314df57e8c39fe0