Zobrazeno 1 - 10
of 200
pro vyhledávání: '"D Borden Lacy"'
Autor:
Kateryna Nabukhotna, Shannon L Kordus, John A Shupe, Rubén Cano Rodríguez, Anna Smith, Julia K Bohannon, M Kay Washington, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 20, Iss 9, p e1012568 (2024)
Clostridioides difficile is a spore-forming pathogen and the most common cause of healthcare-associated diarrhea and colitis in the United States. Besides producing the main virulence factors, toxin A (TcdA) and toxin B (TcdB), many of the common cli
Externí odkaz:
https://doaj.org/article/e4b4bb5a738b4efeab523e61d2c2ba67
Autor:
F. Christopher Peritore-Galve, Izumi Kaji, Anna Smith, Lauren M. Walker, John A. Shupe, M. Kay Washington, Holly M. Scott Algood, Pradeep K. Dudeja, James R. Goldenring, D. Borden Lacy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTBackground & Aim Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determinants of disease. Howe
Externí odkaz:
https://doaj.org/article/24d8cbb83eb34a299947e37b96105dfe
Autor:
Hannah M. Lunnemann, Nicolas G. Shealy, Michelle L. Reyzer, John A. Shupe, Emily H. Green, Uswah Siddiqi, D. Borden Lacy, Mariana X. Byndloss, Nicholas O. Markham
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe mouse cecum has emerged as a model system for studying microbe-host interactions, immunoregulatory functions of the microbiome, and metabolic contributions of gut bacteria. Too often, the cecum is falsely considered as a uniform organ wit
Externí odkaz:
https://doaj.org/article/cf947e7888d24002ac4d1f911649f213
Autor:
Shannon L Kordus, Heather K Kroh, Rubén Cano Rodríguez, Rebecca A Shrem, F Christopher Peritore-Galve, John A Shupe, Brian E Wadzinski, D Borden Lacy, Benjamin W Spiller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011496 (2023)
Clostridioides difficile is a leading cause of antibiotic-associated diarrhea and nosocomial infection in the United States. The symptoms of C. difficile infection (CDI) are associated with the production of two homologous protein toxins, TcdA and Tc
Externí odkaz:
https://doaj.org/article/5c0a09492fa445118a189e4830bc1d37
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Clostridioides difficile is a Gram-positive bacterium that can cause mild to severe diarrhea, inflammation, and colonic tissue damage in animal hosts. Symptoms of the disease can be attributed to the activity of toxin B (TcdB) secreted by C.
Externí odkaz:
https://doaj.org/article/dff8cf7d0a5a476c9c8025648277e4fe
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010997 (2022)
Human infections caused by the toxin-producing, anaerobic and spore-forming bacterium Paeniclostridium sordellii are associated with a treatment-refractory toxic shock syndrome (TSS). Reproductive-age women are at increased risk for P. sordellii infe
Externí odkaz:
https://doaj.org/article/2bfbe9fe9d534ffa87f0b64d827118d6
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010720 (2022)
Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector proteins into a wide range of target cells. The components of T4SSs in gram-negative bacteri
Externí odkaz:
https://doaj.org/article/5f1b0c4e0e2e44808f1e742f81f9e4a2
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Clinical disease from Clostridioides difficile infection can be mediated by two toxins and their neighboring regulatory genes located within the five-gene pathogenicity locus (PaLoc). We provide several lines of evidence that the cytotoxicit
Externí odkaz:
https://doaj.org/article/af015dea3b664b419ccd55adf7c274c6
Autor:
F Christopher Peritore-Galve, John A Shupe, Rory J Cave, Kevin O Childress, M Kay Washington, Sarah A Kuehne, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010323 (2022)
Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. In addition to these symptoms, patients with CDI can develop severe inflammation and tissue damage, resulting in life-threat
Externí odkaz:
https://doaj.org/article/53681cccf54a48f9aac596fac3673cfc
Autor:
Michael J Sheedlo, Jeong Min Chung, Neha Sawhney, Clarissa L Durie, Timothy L Cover, Melanie D Ohi, D Borden Lacy
Publikováno v:
eLife, Vol 9 (2020)
The pathogenesis of Helicobacter pylori-associated gastric cancer is dependent on delivery of CagA into host cells through a type IV secretion system (T4SS). The H. pylori Cag T4SS includes a large membrane-spanning core complex containing five prote
Externí odkaz:
https://doaj.org/article/1dde8d85688348948d757c443b00197a