Zobrazeno 1 - 10
of 16
pro vyhledávání: '"D Blaine, Moore"'
Autor:
James A. Langeland, Lillian Baumann, Eva M. DeYoung, Raphaela Angelina Varella, Nkatha Mwenda, Alejandro Aguirre, D. Blaine Moore
Publikováno v:
Biology, Vol 13, Iss 5, p 320 (2024)
Alzheimer’s disease is characterized, in part, by the accumulation of β-amyloid (Aβ) in the brain. Aβ is produced via the proteolysis of APP by BACE1 and γ-secretase. Since BACE1 is the rate-limiting enzyme in the production of Aβ, and a targe
Externí odkaz:
https://doaj.org/article/911b24f1a258409588d90d17cbe67305
Autor:
Roni Manyevitch, Ian V.J. Murray, Angelica Ortiz, D. Blaine Moore, Rachel A. Gonnella, Jan O. Friedrich, Lucy A. Clunes, Emily Harms, Neil Khoury, Margit Trotz, Anthony Nanajian, Marisa Deliso, Matthew Chang, George Perry, Sean Scarpiello, Stefani Thompson, Brittany Bass, Matthew Protas
Publikováno v:
Current Alzheimer Research
Background: Alzheimer's disease (AD) is currently incurable and a majority of investigational drugs have failed clinical trials. One explanation for this failure may be the invalidity of hypotheses focusing on amyloid to explain AD pathogenesis. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597ec5026db47c21e3ea9e25e033bc26
https://doi.org/10.2174/1567205014666170921122458
https://doi.org/10.2174/1567205014666170921122458
Publikováno v:
Alcohol. 44:553-563
Alcohol abuse, known for promoting apoptosis in the liver and nervous system, is a major public health concern. Despite significant morbidity and mortality resulting from ethanol consumption, the precise cellular mechanism of its toxicity remains unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297bf5602d7f143e9059b1fb17aa7362
https://doi.org/10.1016/j.alcohol.2010.07.003
https://doi.org/10.1016/j.alcohol.2010.07.003
Publikováno v:
Journal of Neurobiology. 60:114-126
The detrimental effects of ethanol exposure during nervous system development have been well established. The cellular mechanisms of ethanol neurotoxicity, however, have not been clearly defined. Recent studies suggest that neurotrophin signaling pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c44d86a949b16a1c12cb8514c80312c
https://doi.org/10.1002/neu.20010
https://doi.org/10.1002/neu.20010
Publikováno v:
Journal of Neurobiology. 60:101-113
Developmental ethanol exposure produces significant central nervous system (CNS) abnormalities. The cellular mechanisms of ethanol neurotoxicity, however, remain elusive. Recent data implicate altered neurotrophin signaling pathways in ethanol-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d79bbcab84e948c8df28a9e3f17d78
https://doi.org/10.1002/neu.20009
https://doi.org/10.1002/neu.20009
Publikováno v:
Alcoholism: Clinical and Experimental Research. 23:1251-1261
Background: The objective of the present work was to determine whether ethanol-induced cerebellar cell death during development is related to alterations in the expression of bcl-2 family genes. Methods: Rats were exposed to ethanol or control condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6377cd8d6ae79e8f4ef809aa23b739ca
https://doi.org/10.1111/j.1530-0277.1999.tb04286.x
https://doi.org/10.1111/j.1530-0277.1999.tb04286.x
Publikováno v:
Brain Research. 817:13-18
The developing nervous system is extremely sensitive to ethanol, and exposure often produces a condition known as the fetal alcohol syndrome. Although mechanisms underlying developmental ethanol toxicity have long been sought, they remain poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0072dd9ea69a27139df0cc5f856db3c0
https://doi.org/10.1016/s0006-8993(98)01173-1
https://doi.org/10.1016/s0006-8993(98)01173-1
Publikováno v:
Alcohol. 15:219-226
The objective of this study was to determine the long-term effects of neonatal ethanol exposure on the cholinergic neurons in the medial septum (MS) of the rat. On postnatal day 4 (P4) pups were assigned to one of three groups: an ethanol-receiving,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614a2358636ad3cea482d784f13baa74
https://doi.org/10.1016/s0741-8329(97)00123-7
https://doi.org/10.1016/s0741-8329(97)00123-7
Publikováno v:
Journal of Neurobiology. 32:684-694
The study described below was performed as a continuation of a previous study in which we found reduced motoneuron number in lumbar spinal cord of the chick embryo following chronic ethanol administration from embryonic day 4 (E4) to E11. We sought t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b9176e3a46b599ccdfcec4d41b919e
https://doi.org/10.1002/(sici)1097-4695(19970620)32:7<684::aid-neu4>3.0.co
https://doi.org/10.1002/(sici)1097-4695(19970620)32:7<684::aid-neu4>3.0.co
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a217aba7067d19fa258a3bd5efe1668
https://doi.org/10.1096/fasebj.22.1_supplement.800.1
https://doi.org/10.1096/fasebj.22.1_supplement.800.1