Zobrazeno 1 - 10
of 39
pro vyhledávání: '"D B Lubahn"'
Autor:
Kenneth S. Korach, J M Hackenberg, D B Lubahn, Kimberly K. Bynoté, Karen A. Gould, Pascale H. Lane
Publikováno v:
Genes & Immunity. 9:137-152
Estrogens promote lupus in humans and some mouse models of this disease. Nonetheless, little is known about the role of estrogen receptors in lupus pathogenesis. Here, we report that in females on the lupus-prone (NZB x NZW)F(1) background, disruptio
Autor:
G. Andersson, Karin Dahlman-Wright, Jan-Ake Gustafsson, Malin C. Erlandsson, Z. Weihua, Hans Carlsten, Sofia Movérare, Olle Vidal, D. B. Lubahn, S. Windahl, Claes Ohlsson, Niklas Andersson, Marie K. Lindberg, H. Gao
Publikováno v:
Journal of Endocrinology. 174:167-178
Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors,
Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments
Publikováno v:
Journal of neurochemistry. 79(4)
Cerebral apolipoprotein E (apoE) has been implicated in neuronal protection and repair. Due to the variable levels and types of estrogen receptors within different brain regions, the effect of estrogen on apoE and the mechanism of this effect may var
Publikováno v:
The Journal of rheumatology. 28(4)
Autor:
T, Kurita, K, Lee, P T, Saunders, P S, Cooke, J A, Taylor, D B, Lubahn, C, Zhao, S, Mäkelä, J A, Gustafsson, R, Dahiya, G R, Cunha
Publikováno v:
Biology of reproduction. 64(1)
Regulation of progesterone receptor (PR) in uterine stroma (endometrial stroma plus myometrium) by estrogen was investigated in estrogen receptor-alpha (ERalpha) knockout (alphaERKO) mice. 17 beta-Estradiol (E(2)) increased PR levels in uterine strom
Publikováno v:
Biology of reproduction. 63(6)
Previous studies of the estrogen receptor-alpha knockout (alpha ERKO) in the male mouse demonstrate that the rete testis and efferent ductules are targets of estrogen. Because the alpha ERKO mouse lacks a functional estrogen receptor alpha (ER alpha)
Publikováno v:
Advances in experimental medicine and biology. 480
Ductal growth during puberty is stimulated by estrogens, which elicit their effects via specific estrogen receptors, ER alpha and ER beta. Analysis of mice with targeted disruption of ER alpha or ER beta has emphasized the importance of ER alpha in m
Publikováno v:
Journal of mammary gland biology and neoplasia. 2(4)
The use of tissue recombinants in conjunction with steroid receptor deficient mice is described as a tool to dissect the complex paracrine pathways of sex-hormone-regulated epithelial growth and ductal morphogenesis in the mammary gland and other hor
Publikováno v:
Biology of reproduction. 62(4)
Regulation of progesterone receptor (PR) by estradiol-17beta (E(2)) in mouse uterine and vaginal epithelia was studied. In ovariectomized mice, PR expression was low in both vaginal stroma and epithelium, but high in uterine epithelium. E(2) induced
Publikováno v:
Biology of reproduction. 62(3)
Estrogen receptor-alpha (ERalpha) knockout (ERalphaKO) female mice are infertile. Initially, they exhibit normal follicular development, but by 4-5 wk of age, they begin to develop hemorrhagic ovarian cysts. Follicles in adult ERalphaKO female mice p