Výsledky vyhledávání

Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide

Autor: Maria Goretti Rodrigues de Queiroz, Manassés C. Fonteles, Joseph Larner, D. B. Heimark, Michael Brownlee, Lucilia Maria Abreu Lessa, Marta Regina Kerntopf, C. M. Sousa, Xueliang Du, John D. Price, Corey S. Davis, Nilberto R.F. Nascimento, Renata de Sousa Alves, Andrew J. Gow

Publikováno v: Proceedings of the National Academy of Sciences. 103:218-223

Endothelial dysfunction (ED) is an early feature of cardiovascular risk and diabetes. Hyperglycemia and hyperlipidemia are causative factors. Excessive endothelial mitochondrial superoxide (ROS) production with hyperglycemia and hyperlipidemia is a k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778d2410b81b5c5faefeaa637d6a3e42
https://doi.org/10.1073/pnas.0509779103

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Gq/11 is involved in insulin-stimulated inositol phosphoglycan putative mediator generation in rat liver membranes: co-localization of Gq/11 with the insulin receptor in membrane vesicles

Autor: S Sleight, B.A Wilson, Joseph Larner, D. B. Heimark

Publikováno v: Biochemical and Biophysical Research Communications. 295:561-569

Insulin signaling to generate inositol phosphoglycans (IPGs) was demonstrated to occur via the participation of the heterotrimeric G-proteins G(q/11). IPGs were measured as two specific inositol markers, myo-inositol and chiro-inositol after strong a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef45a9368d97731cfd9b8ad129f17e4a
https://doi.org/10.1016/s0006-291x(02)00701-5

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Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls

Autor: Joseph Larner, D. B. Heimark, Jan M. McAllister

Publikováno v: Endocrine journal. 61(2)

Previous studies from our and other labs have shown that insulin resistance is associated with an inositol imbalance of excess myo-inositol and deficient chiro-inositol together with a deficiency of myo-inositol to chiro-inositol epimerase in vivo an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b107e8b1767e0401523884aad0afe8
https://pubmed.ncbi.nlm.nih.gov/25739338

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Structural analysis of the light subunit of the Entamoeba histolytica galactose-specific adherence lectin

Autor: Thomas S. Vedvick, Barbara J. Mann, James J. McCoy, D B Heimark, Y Pak, William A. Petri

Publikováno v: Journal of Biological Chemistry. 268:24223-24231

Adherence of Entamoeba histolytica trophozoites to colonic mucins and resistance to lysis by the membrane attack complex of complement are mediated by a galactose- and N-acetyl-D-galactosamine-specific cell-surface lectin. This lectin is a heterodime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90368abd94e49d612e49ab037cdc2259
https://doi.org/10.1016/s0021-9258(20)80514-6

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Synthesis of C-Glycoside Analogues of β-Galactosamine-(1–>4)-3-O-Methyl-D-Chiro-Inositol and Assay as Activator of Protein Phosphatases PDHP and PP2Cα

Autor: David R. Mootoo, David L. Brautigan, Scott Grindrod, D. B. Heimark, Fatoumata Camara, Milton L. Brown, Ahmad S. Altiti, Joseph Larner, Sunej Hans, Alejandro Martin-Montalvo

The glycan beta-galactosamine-(1-4)-3-O-methyl-D-chiro-inositol, called INS-2, was previously isolated from liver as a putative second messenger-modulator for insulin. Synthetic INS-2 injected intravenously in rats is both insulin-mimetic and insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd529648e5469a8344fa76c38ebe2207
https://europepmc.org/articles/PMC3408221/

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Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action

Autor: Scott Grindrod, John H. Bushweller, M. Horal, S. Keller, David L. Brautigan, A. Kruszewski, and A. N. Larner, John D. Price, D. B. Heimark, Joseph Larner, Milton L. Brown, S. M. Lukasik, Shinri Tamura, Gary M. Chinigo

Publikováno v: Biochemistry. 44(33)

Insulin-stimulated glucose disposal in skeletal muscle proceeds predominantly through a nonoxidative pathway with glycogen synthase as a rate-limiting enzyme, yet the mechanisms for insulin activation of glycogen synthase are not understood despite y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6ed7b2708a9cc3dfc83fe06fd5e18c
https://pubmed.ncbi.nlm.nih.gov/16101290

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Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity

Autor: Leigh M. Smith, Carla Pontes, Manassés C. Fonteles, Laura C. Huang, Joseph Larner, John D. Price, Thomas Piccariello, D. B. Heimark, Daniele Vale, Gordon S. Rule

Publikováno v: Journal of medicinal chemistry. 46(15)

We isolated from beef liver a putative insulin mediator termed INS-2, 1. Its structure was determined to be a novel inositol glycan pseudo-disaccharide Mn(2+) chelate containing D-chiro-inositol 2a (as pinitol) and galactosamine. Purification methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfebf055b67504e5fb4cc59028eb4a7
https://pubmed.ncbi.nlm.nih.gov/12852758

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Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls

Autor: Joseph Larner, Thang Nguygen, Tie-hua Sun, Jerry L. Nadler, D. B. Heimark

Publikováno v: Biochemical and biophysical research communications. 293(3)

Previous data from our and other labs demonstrated a decreased chiro-inositol content in urine and tissues of human subjects and animals with type 2 diabetes. In urine this decrease in chiro-inositol was accompanied by an increase in myo-inositol con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d11b9a35b2d8eb781f1fc8080c8890b
https://pubmed.ncbi.nlm.nih.gov/12051772

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A model phosphatase 2C --phosphatase 1 activation cascade via dual control of inhibitor-1 (INH-1) and DARPP-32 dephosphorylation by two inositol glycan putative insulin mediators from beef liver

Autor: R. Nolan, J. Linko, D. B. Heimark, Joseph Larner, Laura C. Huang

Publikováno v: Biochemical and biophysical research communications. 255(1)

Two inositol phosphoglycans (IPG) isolated from beef liver and designated as putative insulin mediators were demonstrated to reciprocally enhance the dephosphorylation of inhibitor-1 (INH-1) and DARPP-32, thus directly activating phosphatase 2C and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c4b83e444440e2e17f669eb290949a
https://pubmed.ncbi.nlm.nih.gov/10082671

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