Zobrazeno 1 - 10
of 68
pro vyhledávání: '"D B, Weiner"'
Publikováno v:
Clinical Diagnostic Laboratory Immunology. 7:751-758
Interleukin 7 (IL-7) protein has been reported to be important in the development of cytotoxic-T-lymphocyte (CTL) responses. However, other studies also support a partial Th2 phenotype for this cytokine. In an effort to clarify this unusual conflict,
Autor:
D B, Weiner, R C, Kennedy
Publikováno v:
Scientific American. 281:50-57
Autor:
J J, Kim, N N, Trivedi, D M, Wilson, S, Mahalingam, L, Morrison, A, Tsai, M A, Chattergoon, K, Dang, M, Patel, L, Ahn, J D, Boyer, A A, Chalian, H, Schoemaker, T, Kieber-Emmons, M A, Agadjanyan, D B, Weiner, H, Shoemaker
Publikováno v:
Oncogene. 17:3125-3135
Nucleic acid immunization has been investigated as immunotherapy for infectious diseases as well as for treating specific types of cancers. In this approach, nucleic acid expression cassettes are directly inoculated into the host, whose transfected c
Publikováno v:
The Journal of Immunology. 158:816-826
Recent studies support the importance of investigating a DNA vaccination approach for the immunologic control of HIV-1. In this regard, it may be important to specifically engineer immune responses in order to improve on first generation vaccine atte
Publikováno v:
The Journal of Immunology. 152:5142-5152
A major cytopathic effect seen upon in vitro infection of CD4+ human T cells by the HIV is cell-to-cell fusion that results in giant cell (or syncytium) formation. Membrane fusion is required for infection by cellfree virions and in syncytium formati
Autor:
J J, Kim, D B, Weiner
Publikováno v:
Methods in molecular medicine. 29
Although the injection of DNA into tissues was originally reported in the 1950s, the technology has gained more attention in recent years as a safe means of mimicking in vivo protein production normally associated with natural infection (1-3). Nuclei
Autor:
A P, Godillot, Q, Fang, T, Higgins, C, Pachuk, J, Boyer, D B, Weiner, S, Lessin, W V, Williams
Publikováno v:
Methods in molecular medicine. 29
T-cell antigen receptor (TCR) genes (which consist of variable (V), diversity (D), joining (J) and constant (C) segments) undergo rearrangement during T-cell development and result in the expression of a disulfide linked heterodimer (α and ß chains
Autor:
K, Muthumani, M, Bagarazzi, D, Conway, D S, Hwang, V, Ayyavoo, D, Zhang, K, Manson, J, Kim, J, Boyer, D B, Weiner
Publikováno v:
Journal of medical primatology. 31(4-5)
We compared the immunogenicity of plasmid vaccines containing multiple human immunodeficiency virus (HIV) antigens and found that covaccination with plasmids expressing HIV-1 14 kDa vpr gene product profoundly reduces antigen-specific CD8-mediated cy
Autor:
J I, Sin, J, Kim, M, Chattergoon, V, Ayyavoo, D, McCallus, K E, Ugen, J D, Boyer, D B, Weiner
Publikováno v:
Developments in biologicals. 104
These studies support the view that additional goals of enhancing DNA vaccine technology will probably be at several levels. The ability to deliver antigens more efficiently to professional APCs is likely to have important implications for our studie
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7
DNA immunization is an important vaccination technique that is being explored as an immunotherapeutic strategy against a variety of infectious diseases as well as cancer. We have been investigating the utility of DNA-based vaccine strategy against pr