Zobrazeno 1 - 10 of 44 pro vyhledávání: '"D B, Wasson"'
1
Lymphocyte dysfunction caused by deficiencies in purine metabolism
Autor: D B Wasson, Ellen Lakow, Dennis A. Carson, Naoyuki Kamatani
Publikováno v: Immunology today. 2(12)
Two inborn errors of purine metabolism have been associated with autosomally inherited human immunodeficiency diseases. A lack of adenosine deaminase (ADA) produces severe lymphopenia and a combined immunodeficiency syndrome. A deficiency of purine n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39e45acb1af3d71b7f85a083f0988aa
https://pubmed.ncbi.nlm.nih.gov/25290650
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2
Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity
Autor: K Houglum, Kwan Sik Lee, Dennis A. Carson, Howard B. Cottam, Mario Chojkier, D B Wasson
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 273:G1094-G1100
Activated, but not quiescent, hepatic stellate cells (lipocytes) have a high level of collagen type I and smooth muscle actin (SMA) gene expression. Therefore, stellate cell activation is a critical step in hepatic fibrosis. The mechanisms leading to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8783eb32feec6ed55a679ea3c102c805
https://doi.org/10.1152/ajpgi.1997.273.5.g1094
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5
Dependence of cell survival on DNA repair in human mononuclear phagocytes
Autor: C Terai, D B Wasson, C J Carrera, D A Carson
Publikováno v: The Journal of Immunology. 147:4302-4306
Mononuclear phagocytes play a central role in the pathogenesis of chronic inflammatory diseases. It is therefore important to define chemotherapeutically exploitable metabolic pathways that distinguish monocytes from other cell types. Blood monocytes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4c3110da37c05ed42c0a14bc7372216
https://doi.org/10.4049/jimmunol.147.12.4302
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6
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha
Autor: D B Wasson, Howard B. Cottam, H. Shih, L. R. Tehrani, Dennis A. Carson
Publikováno v: Journal of medicinal chemistry. 39(1)
A series of analogues of pentoxifylline metabolites were prepared in the purine, pteridine, [1,2,5]-thiadiazolo[3,4-d]pyrimidine, and quinazoline ring systems and evaluated for their ability to inhibit the production of tumor necrosis factor-alpha (T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed13fefd5e6e9f24e3eb5acecd15ac8
https://pubmed.ncbi.nlm.nih.gov/8568809
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7
New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation
Autor: H. Shih, Dennis A. Carson, Raychaudhuri A, Howard B. Cottam, Di Pasquale G, D B Wasson
Publikováno v: Journal of medicinal chemistry. 36(22)
Several 5-iodotubercidin analogues in the pyrazolo[3,4-d]pyrimidine ring system were synthesized as potential inhibitors of adenosine kinase by a direct Lewis acid-catalyzed glycosylation procedure using both the preformed carbohydrate and the hetero
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d176d324375564da392464365c85e0c8
https://pubmed.ncbi.nlm.nih.gov/8230132
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8
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
Autor: D B Wasson, Carlos J. Carrera, Dennis A. Carson, Howard B. Cottam, Thomas J. Kipps, L M Esparza
2-Chlorodeoxyadenosine (CdA) is active in chronic lymphocytic leukemia, hairy-cell leukemia, and low-grade lymphomas. In part, this spectrum of activity may be attributable to the selective toxicity of CdA to nondividing lymphocytes and monocytes. Ho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fc8fad69f3f5da197bd4fcfbc38063
https://europepmc.org/articles/PMC48785/
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9
Dependence of cell survival on DNA repair in human mononuclear phagocytes
Autor: C, Terai, D B, Wasson, C J, Carrera, D A, Carson
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 147(12)
Mononuclear phagocytes play a central role in the pathogenesis of chronic inflammatory diseases. It is therefore important to define chemotherapeutically exploitable metabolic pathways that distinguish monocytes from other cell types. Blood monocytes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18dda9e45d71f5367a50a911399a930a
https://pubmed.ncbi.nlm.nih.gov/1753100
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10
The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts
Autor: D A Carson, J Kaye, D B Wasson
Publikováno v: The Journal of Immunology. 126:348-352
Deoxyadenosine and its nucleotides have been implicated in the pathogenesis of the immune dysfunction associated with a genetic deficiency of adenosine deaminase (ADA). We have previously shown that when ADA is blocked with a synthetic inhibitor, hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adaf975df4e8dab9dd027d8a047ff34d
https://doi.org/10.4049/jimmunol.126.1.348
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