Zobrazeno 1 - 10
of 345
pro vyhledávání: '"D B, Mendel"'
Autor:
W. Lew, S Swaminathan, Raymond C. Stevens, Min Chen, C. Y. Tai, N Bischofberger, Lijun Zhang, W. G. Laver, Hua-Kun Liu, M.A. Williams, C U Kim, D. B. Mendel
Publikováno v:
Journal of the American Chemical Society. 119:681-690
The design, synthesis, and in vitro evaluation of the novel carbocycles as transition-state-based inhibitors of influenza neuraminidase (NA) are described. The double bond position in the carbocyclic analogues plays an important role in NA inhibition
Autor:
Wei, Yu‐Sen1 (AUTHOR), Tang, Wen‐Jie1 (AUTHOR), Mao, Pei‐Yu2 (AUTHOR), Mao, Jiang‐Di1 (AUTHOR), Ni, Zhi‐Xiang1 (AUTHOR), Hou, Kang‐Wei1 (AUTHOR), Valencak, Teresa G.1 (AUTHOR), Liu, Da‐Ren3 (AUTHOR), Ji, Jun‐Fang4 (AUTHOR), Wang, Hai‐Feng1 (AUTHOR) haifengwang@zju.edu.cn
Publikováno v:
Advanced Science. 8/14/2024, Vol. 11 Issue 30, p1-20. 20p.
Publikováno v:
The Journal of Immunology. 145:267-275
The high affinity IgG FcR Fc gamma RI, CD64, plays important roles in the immune response. Fc gamma RI is predominantly expressed on monocytes and macrophages, and barely detectable on neutrophils. rIFN-gamma markedly increases the expression of Fc g
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:2120-2122
It has been observed that herpes simplex virus mutants with deficient or altered thymidine kinase activity are more susceptible to Cidofovir (CDV; 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine dihydrate) in tissue culture than are the parental
Autor:
J G, Christensen, R E, Schreck, E, Chan, X, Wang, C, Yang, L, Liu, J, Cui, L, Sun, J, Wei, J M, Cherrington, D B, Mendel
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(12)
The epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases have been implicated in the development, progression, and severity of several human cancers and are attractive targets for therapeutic intervention. SU11925 was developed as a sma
Autor:
D B, Mendel, R E, Schreck, D C, West, G, Li, L M, Strawn, S S, Tanciongco, S, Vasile, L K, Shawver, J M, Cherrington
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(12)
SU5416, a selective inhibitor of the tyrosine kinase activity of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR, is currently in Phase III clinical trials for the treatment of advanced malignancies. In cellular assays, SU5416 inhibi
Autor:
D B, Mendel, A D, Laird, B D, Smolich, R A, Blake, C, Liang, A L, Hannah, R M, Shaheen, L M, Ellis, S, Weitman, L K, Shawver, J M, Cherrington
Publikováno v:
Anti-cancer drug design. 15(1)
Angiogenesis, or the sprouting of new blood vessels, is a central process in the growth of solid tumors. For many cancers, the extent of vascularization of a tumor is a negative prognostic indicator signifying aggressive disease and increased potenti
Autor:
Raymond C. Stevens, W. Lew, Lijun Zhang, Huiwei Wu, D. B. Mendel, Xiaowu Chen, W. G. Laver, Choung U. Kim, M.A. Williams, Paul A. Escarpe
Publikováno v:
Journal of medicinal chemistry. 41(14)
A series of influenza neuraminidase inhibitors with the cyclohexene scaffold containing lipophilic side chains have been synthesized and evaluated for influenza A and B neuraminidase inhibitory activity. The size and geometry of side chains have been
Publikováno v:
Antimicrobial agents and chemotherapy. 41(3)
Cidofovir (HPMPC) [1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]-cytosine] is an acyclic nucleotide analog with potent and selective activity against herpesviruses. The prodrug, cyclic HPMPC (cHPMPC) [1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-
Autor:
D B, Mendel, G R, Crabtree
Publikováno v:
The Journal of biological chemistry. 266(2)