Výsledky vyhledávání

Regulation of the steady state level of Fc gamma RI mRNA by IFN-gamma and dexamethasone in human monocytes, neutrophils, and U-937 cells

Autor: L Y Pan, D B Mendel, J Zurlo, P M Guyre

Publikováno v: The Journal of Immunology. 145:267-275

The high affinity IgG FcR Fc gamma RI, CD64, plays important roles in the immune response. Fc gamma RI is predominantly expressed on monocytes and macrophages, and barely detectable on neutrophils. rIFN-gamma markedly increases the expression of Fc g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db75c1ad8f9d8835928038fe1982d284
https://doi.org/10.4049/jimmunol.145.1.267

Zobrazit plný text záznamu

Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity

Autor: D B Barkhimer, M S Chen, D B Mendel

Publikováno v: Antimicrobial Agents and Chemotherapy. 39:2120-2122

It has been observed that herpes simplex virus mutants with deficient or altered thymidine kinase activity are more susceptible to Cidofovir (CDV; 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine dihydrate) in tissue culture than are the parental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8d773eecc72cbd6766b8fc0f6a3232
https://doi.org/10.1128/aac.39.9.2120

Zobrazit plný text záznamu

High levels of HER-2 expression alter the ability of epidermal growth factor receptor (EGFR) family tyrosine kinase inhibitors to inhibit EGFR phosphorylation in vivo

Autor: J G, Christensen, R E, Schreck, E, Chan, X, Wang, C, Yang, L, Liu, J, Cui, L, Sun, J, Wei, J M, Cherrington, D B, Mendel

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(12)

The epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases have been implicated in the development, progression, and severity of several human cancers and are attractive targets for therapeutic intervention. SU11925 was developed as a sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ef1f64019542a5724c467d5c23ba39c
https://pubmed.ncbi.nlm.nih.gov/11751524

Zobrazit plný text záznamu

The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function

Autor: D B, Mendel, R E, Schreck, D C, West, G, Li, L M, Strawn, S S, Tanciongco, S, Vasile, L K, Shawver, J M, Cherrington

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(12)

SU5416, a selective inhibitor of the tyrosine kinase activity of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR, is currently in Phase III clinical trials for the treatment of advanced malignancies. In cellular assays, SU5416 inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f858777337e62ff407dc874da23dd5be
https://pubmed.ncbi.nlm.nih.gov/11156244

Zobrazit plný text záznamu

Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent

Autor: D B, Mendel, A D, Laird, B D, Smolich, R A, Blake, C, Liang, A L, Hannah, R M, Shaheen, L M, Ellis, S, Weitman, L K, Shawver, J M, Cherrington

Publikováno v: Anti-cancer drug design. 15(1)

Angiogenesis, or the sprouting of new blood vessels, is a central process in the growth of solid tumors. For many cancers, the extent of vascularization of a tumor is a negative prognostic indicator signifying aggressive disease and increased potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b51cd58b87338fdd8465f3efa6c25cb
https://pubmed.ncbi.nlm.nih.gov/10888034

Zobrazit plný text záznamu

Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors

Autor: Raymond C. Stevens, W. Lew, Lijun Zhang, Huiwei Wu, D. B. Mendel, Xiaowu Chen, W. G. Laver, Choung U. Kim, M.A. Williams, Paul A. Escarpe

Publikováno v: Journal of medicinal chemistry. 41(14)

A series of influenza neuraminidase inhibitors with the cyclohexene scaffold containing lipophilic side chains have been synthesized and evaluated for influenza A and B neuraminidase inhibitory activity. The size and geometry of side chains have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06242f5cb50bcc9eefebede36dec59d
https://pubmed.ncbi.nlm.nih.gov/9651151

Zobrazit plný text záznamu

Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase

Autor: D B Mendel, M S Chen, K Moon, T Cihlar

Publikováno v: Antimicrobial agents and chemotherapy. 41(3)

Cidofovir (HPMPC) [1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]-cytosine] is an acyclic nucleotide analog with potent and selective activity against herpesviruses. The prodrug, cyclic HPMPC (cHPMPC) [1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f91b47cca1576df2db707e71295b19b
https://pubmed.ncbi.nlm.nih.gov/9056007

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání