Zobrazeno 1 - 10 of 13 pro vyhledávání: '"D B, Kohn"'
2
Growth factors increase amphotropic retrovirus binding to human CD34+ bone marrow progenitor cells
Autor: G M, Crooks, D B, Kohn
Publikováno v: Blood. 82:3290-3297
Gene transfer into human cells using murine amphotropic retroviral vectors is the basic technique used in most current gene therapy studies. The identity of the cell surface receptor for the amphotropic envelope remains unknown and thus its importanc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fecb728f57d1cc6869fcb79086e74b
https://doi.org/10.1182/blood.v82.11.3290.bloodjournal82113290
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3
Gene therapy using hematopoietic stem cells
Autor: D B, Kohn
Publikováno v: Current opinion in molecular therapeutics. 1(4)
While gene therapy using hematopoietic stem cells was the first area of investigation in the field, success has proven elusive. However, significant progress has been achieved recently in methods for more effective gene transfer and expression. In ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6255b36b209d00bd5f6575fbacfd6fc2
https://pubmed.ncbi.nlm.nih.gov/11713757
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5
BTK mediated apoptosis, a possible mechanism for failure to generate high titer retroviral producer clones
Autor: T C, Islam, L J, Brandén, D B, Kohn, K B, Islam, C I, Smith
Publikováno v: The journal of gene medicine. 2(3)
It has been shown previously that mutations in the cytoplasmic protein kinase, Bruton's tyrosine kinase (BTK) lead to X-linked agammaglobulinemia, an inherited primary immunodeficiency, thus making it a potential candidate for gene therapy.Producer c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9383381fdf72130a44d910e37d08ccf2
https://pubmed.ncbi.nlm.nih.gov/10894266
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6
Gene therapy for congenital lymphoid immunodeficiency diseases
Autor: K I, Weinberg, D B, Kohn
Publikováno v: Seminars in hematology. 35(4)
The primary immunodeficiencies are a group of rare genetic diseases in which mutations of genes necessary for host defense result in increased susceptibility to infection. In the past 10 years, the genes responsible for most forms of human immunodefi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4163a74e189b25dda7786df843057b14
https://pubmed.ncbi.nlm.nih.gov/9801264
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7
Gene therapy for haematopoietic and lymphoid disorders
Autor: D B, Kohn
Publikováno v: Clinical and experimental immunology. 107
Gene transfer into haematopoietic stem cells (HSC) has been investigated for treatment of genetic disorders, conferral of chemotherapy resistance and insertion of genes to inhibit HIV-1 replication. Methods have been available for almost a decade to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d30327f6383cd5ef24e73869eee6ca9
https://pubmed.ncbi.nlm.nih.gov/9020937
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8
Gene therapy for hematopoietic and immune disorders
Autor: D B, Kohn
Publikováno v: Bone marrow transplantation. 18
Gene therapy is a novel approach under investigation for the treatment of genetic diseases, cancer and AIDS. Hematopoietic stem cells would be the target cell for correction of hemoglobinopathies, immune deficiencies and lysosomal storage diseases. R
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73be8531fb672556304c72f91b1e7ec4
https://pubmed.ncbi.nlm.nih.gov/8971410
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