Building a flagellum in biological outer space

Autor: Lewis D. B. Evans, Colin Hughe, Gillian M. Fraser

Publikováno v: Microbial Cell, Vol 1, Iss 2, Pp 64-66 (2014)

Flagella, the rotary propellers on the surface of bacteria, present a paradigm for how cells build and operate complex molecular ‘nanomachines’. Flagella grow at a constant rate to extend several times the length of the cell, and this is achieved

Externí odkaz: https://doaj.org/article/669a52e586944d99862c3f300b4ea613

Whole genome CRISPR screens identify LRRK2-regulated endocytosis as a major mechanism for extracellular tau uptake by human neurons

Autor: Frederick J. Livesey, A. Campbell, Andrew R. Bassett, Lewis D. B. Evans, Francesco Iorio, Alessio Strano, Emre Karakoc

Pathological protein aggregation in Alzheimer’s disease and other dementias is proposed to spread through the nervous system by a process of intercellular transfer of pathogenic forms of tau protein. Defining the cellular mechanisms of tau entry to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f43d61dc54bee407299ac28950ad972e
https://doi.org/10.1101/2020.08.11.246363

A walk through tau therapeutic strategies

Autor: Luc Buée, Rohan de Silva, Gabor G. Kovacs, Norbert Zilka, Rostislav Skrabana, Eniko Veronika Kovari, Eva Kontsekova, Michael Schöll, Barbara Malawska, Santosh Jadhav, Jesús Avila, Lewis D. B. Evans

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Acta Neuropathologica Communications, Vol. 7, No 1 (2019) P. 22
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-31 (2019)

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease and related human tauopathies. There is a growing body of evidence indicating that pathological tau species can travel from cell to cell and spread the patholog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc35293d8eb931a43828e414cb0b1f1
http://hdl.handle.net/10261/213563

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Autor: Scherazad Kootar, Marc Aurel Busche, Steven Moore, Lewis D. B. Evans, Sabina Tahirovic, Daniel Hornburg, Dietmar Rudolf Thal, Anna Daria, Hélène Marie, Jochen Herms, Frederick J. Livesey, Christian Haass, Elisabeth Kremmer, Vilmantas Giedraitis, Felix Meissner, Heike Hampel, Veronika Müller, Ulrike Müller, Michael Willem, Camilla Giudici, Saak V. Ovsepian, Michael T. Heneka, Brigitte Nuscher, Lars Lannfelt, Andrea Wenninger-Weinzierl, Arthur Konnerth, Magda Chafai

Publikováno v: Nature
Nature, Nature Publishing Group, 2015, 526 (7573), pp.443-447. ⟨10.1038/nature14864⟩
Nature 526(7573), 443-447 (2015). doi:10.1038/nature14864

Alzheimer's disease (AD) is characterized by the accumulation of amyloid plaques, which are predominantly composed of amyloid β-peptide (Aβ)1. Two principal physiological pathways either prevent or promote Aβ generation from its precursor (amyloid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cec13516a5dc15f10dd6a6f2dda54c8
https://doi.org/10.1038/nature14864

Interactions of Flagellar Structural Subunits with the Membrane Export Machinery

Autor: Lewis D B, Evans, Paul M, Bergen, Owain J, Bryant, Gillian M, Fraser

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1593

During assembly of the bacterial flagellum, structural subunits synthesized inside the cell must be exported across the cytoplasmic membrane before they can crystallize into the nascent flagellar structure. This export process is facilitated by a spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7af19794bf5272a5134079fc47d1c91c
https://pubmed.ncbi.nlm.nih.gov/28389942