Zobrazeno 1 - 10 of 35 pro vyhledávání: '"D B, Drachman"'
2
Specific immunotherapy of experimental myasthenia by genetically engineered APCs: the 'guided missile' strategy
Autor: D B, Drachman, J-M, Wu, A, Miagkov, M A, Williams, R N, Adams, B, Wu
Publikováno v: Annals of the New York Academy of Sciences. 998
Although treatment of MG with general immunosuppressive agents is often effective, it has important drawbacks, including suppression of the immune system as a whole, with the risks of infection and neoplasia, and numerous other adverse side effects.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a521e1bc6f2adde4be8f28b3a8fc64a
https://pubmed.ncbi.nlm.nih.gov/14592923
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3
Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis
Autor: D B, Drachman, J D, Rothstein
Publikováno v: Annals of neurology. 48(5)
The pathogenesis of motor neuron loss in amyotrophic lateral sclerosis (ALS) is thought to involve both glutamate-mediated excitotoxicity and oxidative damage due to the accumulation of free radicals and other toxic molecules. Cyclooxygenase-2 (COX-2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e74bf1a09cc2b324bb485a5f86cd7a16
https://pubmed.ncbi.nlm.nih.gov/11079544
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4
Extended cervicomediastinal thymectomy in the integrated management of myasthenia gravis
Autor: D B Drachman, Saby George, Gregory B. Bulkley, P A Reilly, G R Stephenson, Marie Diener-West, K N Bass, R R Baker
Publikováno v: Annals of surgery. 226(3)
OBJECTIVE: The authors evaluated the response to extended cervicomediastinal thymectomy as a component of the integrated management of patients with myasthenia gravis in a large series of patients from a single institution. The authors evaluated the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e676c46e7261ac883c5249a4dea790e4
https://pubmed.ncbi.nlm.nih.gov/9339939
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5
Immunotherapy in neuromuscular disorders: current and future strategies
Autor: D B, Drachman
Publikováno v: Musclenerve. 19(10)
Autoimmune mechanisms have recently been implicated in the pathogenesis of an increasing number of neuromuscular diseases. Many of these diseases can be treated with immunotherapeutic agents that are currently available--often with striking success.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d43cdc0e742f7ce6a21fdd30c408a86
https://pubmed.ncbi.nlm.nih.gov/8808649
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6
Corneal decompensation in mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. A clinicopathologic case report
Autor: Donald R. Johns, D B Drachman, William R. Green, W J Stark, T S Chang
Publikováno v: Cornea. 13(3)
The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17100b2f9ffe7178845108e1558d955d
https://pubmed.ncbi.nlm.nih.gov/8033580
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8
3-Deazaadenosine: a therapeutic strategy for myasthenia gravis by decreasing the endocytosis of acetylcholine receptors
Autor: R W, Kuncl, D B, Drachman, R, Adams, M, Lehar
Publikováno v: The Journal of pharmacology and experimental therapeutics. 267(2)
The basic abnormality in myasthenia gravis is the depletion of acetylcholine receptors (AChRs) at neuromuscular junctions, which is due in part to excessive endocytosis brought about by the action of pathogenic antibodies. We asked whether 3-deazaade
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::126b6780f4f198b0da37c939f7559858
https://pubmed.ncbi.nlm.nih.gov/8246131
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