Zobrazeno 1 - 10
of 64
pro vyhledávání: '"D Allan Drummond"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 10, p e1011565 (2023)
Understanding how protein sequences confer function remains a defining challenge in molecular biology. Two approaches have yielded enormous insight yet are often pursued separately: structure-based, where sequence-encoded structures mediate function,
Externí odkaz:
https://doaj.org/article/40cc7b87a8974ed7808832dd547080a9
Publikováno v:
eLife, Vol 9 (2020)
Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thou
Externí odkaz:
https://doaj.org/article/97f1c9ac38f7443a8b8ae635218967bc
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005206 (2015)
Cells respond to their environment by modulating protein levels through mRNA transcription and post-transcriptional control. Modest observed correlations between global steady-state mRNA and protein measurements have been interpreted as evidence that
Externí odkaz:
https://doaj.org/article/44623f390e4845648aaf06b2d44805b2
Autor:
John M Zaborske, Vanessa L Bauer DuMont, Edward W J Wallace, Tao Pan, Charles F Aquadro, D Allan Drummond
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002150 (2015)
[This corrects the article DOI: 10.1371/journal.pbio.1002015.].
Externí odkaz:
https://doaj.org/article/71a8e05366014d609769e88ff5e34423
Autor:
John M Zaborske, Vanessa L Bauer DuMont, Edward W J Wallace, Tao Pan, Charles F Aquadro, D Allan Drummond
Publikováno v:
PLoS Biology, Vol 12, Iss 12, p e1002015 (2014)
Natural selection favors efficient expression of encoded proteins, but the causes, mechanisms, and fitness consequences of evolved coding changes remain an area of aggressive inquiry. We report a large-scale reversal in the relative translational acc
Externí odkaz:
https://doaj.org/article/188428a8e76041d283d970c8e04a15fd
Autor:
Kerry A Geiler-Samerotte, Tatsunori Hashimoto, Michael F Dion, Bogdan A Budnik, Edoardo M Airoldi, D Allan Drummond
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75320 (2013)
Countless studies monitor the growth rate of microbial populations as a measure of fitness. However, an enormous gap separates growth-rate differences measurable in the laboratory from those that natural selection can distinguish efficiently. Taking
Externí odkaz:
https://doaj.org/article/1e79a9a4385c4b17ba41b611abd5fc00
Publikováno v:
Molecular Cell. 82:2544-2556
Stress-induced condensation of mRNA and protein into massive cytosolic clusters is conserved across eukaryotes. Known as stress granules when visible by imaging, these structures remarkably have no broadly accepted biological function, mechanism of f
Publikováno v:
bioRxiv
Understanding how protein sequences confer function remains a defining challenge in molecular biology. Two approaches have yielded enormous insight yet are often pursued separately: structure-based, where sequence-encoded structures mediate function,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee1a925c3aff7d829876c8ab35131b0
https://europepmc.org/articles/PMC9949069/
https://europepmc.org/articles/PMC9949069/
Autor:
Asif Ali, Rania Garde, Olivia C Schaffer, Jared A M Bard, Kabir Husain, Samantha Keyport Kik, Kathleen A Davis, Sofia Luengo-Woods, D Allan Drummond, Allison H Squires, David Pincus
Ribosome biogenesis is among the most resource-intensive cellular processes, with ribosomal proteins accounting for up to half of all newly synthesized proteins in eukaryotic cells. During stress, cells shut down ribosome biogenesis in part by haltin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e20a5eef94535cbb1c53cb8418cb66
https://doi.org/10.1101/2022.11.09.515856
https://doi.org/10.1101/2022.11.09.515856
Autor:
Hendrik Glauninger, Jared Bard, Caitlin Wong Hickernell, Tobin R. Sosnick, Edward Wallace, D. Allan Drummond
Publikováno v:
Biophysical Journal. 122:484a-485a