Zobrazeno 1 - 10
of 4 678
pro vyhledávání: '"D Allan"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 10, p e1011565 (2023)
Understanding how protein sequences confer function remains a defining challenge in molecular biology. Two approaches have yielded enormous insight yet are often pursued separately: structure-based, where sequence-encoded structures mediate function,
Externí odkaz:
https://doaj.org/article/40cc7b87a8974ed7808832dd547080a9
Publikováno v:
eLife, Vol 9 (2020)
Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thou
Externí odkaz:
https://doaj.org/article/97f1c9ac38f7443a8b8ae635218967bc
Autor:
Chu, Jiachong, Ejaz, Ayesha, Lin, Kyle M., Joseph, Madeline R., Coraor, Aria E., Drummond, D. Allan, Squires, Allison H.
Multiplexed, real-time fluorescence detection at the single-molecule level is highly desirable to reveal the stoichiometry, dynamics, and interactions of individual molecular species within complex systems. However, traditionally fluorescence sensing
Externí odkaz:
http://arxiv.org/abs/2307.01614
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005206 (2015)
Cells respond to their environment by modulating protein levels through mRNA transcription and post-transcriptional control. Modest observed correlations between global steady-state mRNA and protein measurements have been interpreted as evidence that
Externí odkaz:
https://doaj.org/article/44623f390e4845648aaf06b2d44805b2
Autor:
John M Zaborske, Vanessa L Bauer DuMont, Edward W J Wallace, Tao Pan, Charles F Aquadro, D Allan Drummond
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002150 (2015)
[This corrects the article DOI: 10.1371/journal.pbio.1002015.].
Externí odkaz:
https://doaj.org/article/71a8e05366014d609769e88ff5e34423
Autor:
John Hayslip, Emily V Dressler, Heidi Weiss, Tammy J Taylor, Mara Chambers, Teresa Noel, Sumitra Miriyala, Jeriel T R Keeney, Xiaojia Ren, Rukhsana Sultana, Mary Vore, D Allan Butterfield, Daret St Clair, Jeffrey A Moscow
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124988 (2015)
Chemotherapy-induced cognitive impairment (CICI) is a common sequelae of cancer therapy. Recent preclinical observations have suggested that CICI can be mediated by chemotherapy-induced plasma protein oxidation, which triggers TNF-α mediated CNS dam
Externí odkaz:
https://doaj.org/article/8e1bb119d4ac4a6881744d355ef08626
Autor:
John M Zaborske, Vanessa L Bauer DuMont, Edward W J Wallace, Tao Pan, Charles F Aquadro, D Allan Drummond
Publikováno v:
PLoS Biology, Vol 12, Iss 12, p e1002015 (2014)
Natural selection favors efficient expression of encoded proteins, but the causes, mechanisms, and fitness consequences of evolved coding changes remain an area of aggressive inquiry. We report a large-scale reversal in the relative translational acc
Externí odkaz:
https://doaj.org/article/188428a8e76041d283d970c8e04a15fd
Autor:
Lanzillotta, Chiara, Tramutola, Antonella, Lanzillotta, Simona, Greco, Viviana, Pagnotta, Sara, Sanchini, Caterina, Di Angelantonio, Silvia, Forte, Elena, Rinaldo, Serena, Paone, Alessio, Cutruzzolà, Francesca, Cimini, Flavia Agata, Barchetta, Ilaria, Cavallo, Maria Gisella, Urbani, Andrea, Butterfield, D. Allan, Di Domenico, Fabio, Paul, Bindu D., Perluigi, Marzia, Duarte, Joao M.N., Barone, Eugenio
Publikováno v:
In Redox Biology July 2024 73
Autor:
Kerry A Geiler-Samerotte, Tatsunori Hashimoto, Michael F Dion, Bogdan A Budnik, Edoardo M Airoldi, D Allan Drummond
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75320 (2013)
Countless studies monitor the growth rate of microbial populations as a measure of fitness. However, an enormous gap separates growth-rate differences measurable in the laboratory from those that natural selection can distinguish efficiently. Taking
Externí odkaz:
https://doaj.org/article/1e79a9a4385c4b17ba41b611abd5fc00