Zobrazeno 1 - 10
of 400
pro vyhledávání: '"D A Watkins"'
Autor:
Hirotsugu Aiga, Yoshito Kawakatsu, Christopher Adolph, Jonathan F Mosser, Peter Baffoe, Fatima Cheshi, Kenneth H Sherr, D A Watkins
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Background National-level coverage estimates of maternal and child health (MCH) services mask district-level and community-level geographical inequities. The purpose of this study is to estimate grid-level coverage of essential MCH services in Nigeri
Externí odkaz:
https://doaj.org/article/e3a7018b6784425cbf21742e9e7afee8
Autor:
Jasmine Chen, Aleks C. Guanizo, W. Samantha N. Jakasekara, Chaitanya Inampudi, Quinton Luong, Daniel J. Garama, Muhammad Alamgeer, Nishant Thakur, Michael DeVeer, Vinod Ganju, D. Neil Watkins, Jason E. Cain, Daniel J. Gough
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer with an appalling overall survival of less than 5% (Zimmerman et al. J Thor Oncol 14:768-83, 2019). Patients typically respond to front line platinum-based doubl
Externí odkaz:
https://doaj.org/article/188977388363466f976932deaf19e20a
Autor:
Kamila A. Marzec, Samuel Rogers, Rachael McCloy, Benjamin L. Parker, David E. James, D. Neil Watkins, Andrew Burgess
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Microtubule-associated serine/threonine kinase-like (MASTL) has emerged as a critical regulator of mitosis and as a potential oncogene in a variety of cancer types. To date, Arpp-19/ENSA are the only known substrates of MASTL. However, with
Externí odkaz:
https://doaj.org/article/3331cc1a3f214642bc1ecc88d07abe93
Autor:
Elizabeth Verghese, Luciano G. Martelotto, Jason E. Cain, Timothy M. Williams, Andrea F. Wise, Prudence A. Hill, Robyn G. Langham, D. Neil Watkins, Sharon D. Ricardo, James A. Deane
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-5 (2019)
Abstract Objectives Primary cilia are sensory organelles which co-ordinate several developmental/repair pathways including hedgehog signalling. Studies of human renal allografts suffering acute tubular necrosis have shown that length of primary cilia
Externí odkaz:
https://doaj.org/article/a31dfc080efe47298fc3af1f190a70ba
Autor:
Alvaro Gonzalez Rajal, Kamila A Marzec, Rachael A McCloy, Max Nobis, Venessa Chin, Jordan F Hastings, Kaitao Lai, Marina Kennerson, William E Hughes, Vijesh Vaghjiani, Paul Timpson, Jason E Cain, D Neil Watkins, David R Croucher, Andrew Burgess
Publikováno v:
eLife, Vol 10 (2021)
We previously used a pulse-based in vitro assay to unveil targetable signalling pathways associated with innate cisplatin resistance in lung adenocarcinoma (Hastings et al., 2020). Here, we advanced this model system and identified a non-genetic mech
Externí odkaz:
https://doaj.org/article/2218265a2a26450eb03d27ef3e339032
Autor:
Sean P. Kennedy, Jeremy Z. R. Han, Neil Portman, Max Nobis, Jordan F. Hastings, Kendelle J. Murphy, Sharissa L. Latham, Antonia L. Cadell, Dushan Miladinovic, Gabriella R. Marriott, Yolande E. I. O’Donnell, Robert F. Shearer, James T. Williams, Amaya Garcia Munoz, Thomas R. Cox, D. Neil Watkins, Darren N. Saunders, Paul Timpson, Elgene Lim, Walter Kolch, David R. Croucher
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-17 (2019)
Abstract Background The oncogenic receptor tyrosine kinase (RTK) ERBB2 is known to dimerize with other EGFR family members, particularly ERBB3, through which it potently activates PI3K signalling. Antibody-mediated inhibition of this ERBB2/ERBB3/PI3K
Externí odkaz:
https://doaj.org/article/63c93a219e074dd1a11996f46df83abd
Autor:
Ira W. Deveson, Bindu Swapna Madala, James Blackburn, Chris Barker, Ted Wong, Kirston M. Barton, Martin A. Smith, D. Neil Watkins, Tim R. Mercer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Any DNA sequence can be represented by a chiral partner sequence – an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequenc
Externí odkaz:
https://doaj.org/article/eff97fe0e26c48849a3f468dba362eb7
Autor:
Chae Ho Lim, Qi Sun, Karan Ratti, Soung-Hoon Lee, Ying Zheng, Makoto Takeo, Wendy Lee, Piul Rabbani, Maksim V. Plikus, Jason E. Cain, David H. Wang, D. Neil Watkins, Sarah Millar, M. Mark Taketo, Peggy Myung, George Cotsarelis, Mayumi Ito
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
On wounding, scar formation in mammals arises causing no hair follicle regeneration, but it is unclear if scarring precludes regeneration. Here, the authors show that if Sonic hedgehog signaling is activated in the wound, an inductive dermal niche fo
Externí odkaz:
https://doaj.org/article/22d3911c85504d6b96c4c30019908e9e
Autor:
Jason E. Cain, D. Neil Watkins
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of
Externí odkaz:
https://doaj.org/article/097e89e2fad2451e83d02f3800275893
Autor:
Jordan F Hastings, Alvaro Gonzalez Rajal, Sharissa L Latham, Jeremy ZR Han, Rachael A McCloy, Yolande EI O'Donnell, Monica Phimmachanh, Alexander D Murphy, Adnan Nagrial, Dariush Daneshvar, Venessa Chin, D Neil Watkins, Andrew Burgess, David R Croucher
Publikováno v:
eLife, Vol 9 (2020)
The identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has previously been hampered by inappropriately tailored in vitro assays of drug response. Therefore, using a pulse model tha
Externí odkaz:
https://doaj.org/article/6cdc2a0c965744e3b31564628d883756