Zobrazeno 1 - 10
of 656
pro vyhledávání: '"D A Smyth"'
Autor:
Leisha M. Armijo, Stephen J. Wawrzyniec, Michael Kopciuch, Yekaterina I. Brandt, Antonio C. Rivera, Nathan J. Withers, Nathaniel C. Cook, Dale L. Huber, Todd C. Monson, Hugh D. C. Smyth, Marek Osiński
Publikováno v:
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-27 (2020)
Abstract Background Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common infectious species of the Pseudomonas genus, P. aeruginosa is the primary Gram-
Externí odkaz:
https://doaj.org/article/7930d1949eb14b0b901971b2b96e818d
Autor:
Yuanyuan Xue, Youwu Liao, Haiqiao Wang, Shuang Li, Zhengqing Gu, Michael Adu‐Frimpong, Jiangnan Yu, Ximing Xu, Hugh D. C Smyth, Yuan Zhu
Publikováno v:
Journal of the Science of Food and Agriculture. 103:3628-3637
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246803 (2021)
Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Though NIC is already FDA-approved, administration of the currently available oral formulation results in syste
Externí odkaz:
https://doaj.org/article/7b9a8a6ac8854a72a9191dcad8183f84
Autor:
Li Ding, Ashlee D. Brunaugh, Sven Stegemann, Scott V. Jermain, Matthew J. Herpin, Justin Kalafat, Hugh D. C. Smyth
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1213 (2021)
Capsule-based dry powder inhalers (cDPIs) are widely utilized in the delivery of pharmaceutical powders to the lungs. In these systems, the fundamental nature of the interactions between the drug/formulation powder, the capsules, the inhaler device,
Externí odkaz:
https://doaj.org/article/f96b50400fd64ad794997089c4e78a70
Autor:
Xin Hua, Qin Yang, Zhimin Dong, Jiashuo Zhang, Wanjiang Zhang, Qiudong Wang, Shengnan Tan, Hugh D. C. Smyth
Publikováno v:
Drug Delivery, Vol 24, Iss 1, Pp 511-518 (2017)
The objective of this study was to describe the magnetic nanoparticle–drug conjugates for improved control of drug delivery and drug release. The widely used anticancer agent Doxorubicin (DOX) was successfully conjugated via amine groups to the car
Externí odkaz:
https://doaj.org/article/3d5680ad73374e44b1672084b85ac235
Autor:
Shayden Fritz, Leisha M. Armijo, Kayla Simpson, Kimberly Lopez, Marek Osinski, Nihal Bandara, Hugh D. C. Smyth, Jian Sheng, Wei Xu
Publikováno v:
Colloidal Nanoparticles for Biomedical Applications XVIII.
Publikováno v:
Journal of Pharmaceutical Sciences. 111:403-416
Monoclonal antibody (mAb) based therapies may provide a valuable new treatment modality for acute and chronic lung diseases, including asthma, respiratory infections, and lung cancer. Currently mAbs are delivered via systemic administration routes, b
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1042 (2020)
Messenger RNA is a class of promising nucleic acid therapeutics to treat a variety of diseases, including genetic diseases. The development of a stable and efficacious mRNA pulmonary delivery system would enable high therapeutic concentrations locall
Externí odkaz:
https://doaj.org/article/e2b681aa87a04ae595442d25ab47190e
Publikováno v:
Fundamentals of Drug Delivery. :449-469
Autor:
Ashlee D. Brunaugh, Amanda Walz, Zachary Warnken, Camron Pearce, Juan Munoz Gutierrez, John J. Koleng, Hugh D. C. Smyth, Mercedes Gonzalez-Juarrero
Publikováno v:
Antimicrob Agents Chemother
Tuberculosis (TB) remains a major cause of morbidity and mortality, particularly in low- and middle-income countries where access to health care workers, cold-chain storage, and sterile water sources may be limited. Inhaled drug delivery is a promisi