Natural history of limb girdle muscular dystrophy R9 over 6 years: searching for trial endpoints

Autor: Alexander P. Murphy, Jasper Morrow, Julia R. Dahlqvist, Tanya Stojkovic, Tracey A. Willis, Christopher D. J. Sinclair, Stephen Wastling, Tarek Yousry, Michael S. Hanna, Meredith K. James, Anna Mayhew, Michelle Eagle, Laurence E. Lee, Jean‐Yves Hogrel, Pierre G. Carlier, John S. Thornton, John Vissing, Kieren G. Hollingsworth, Volker Straub

Publikováno v: Annals of Clinical and Translational Neurology, Vol 6, Iss 6, Pp 1033-1045 (2019)

Abstract Objective Limb girdle muscular dystrophy type R9 (LGMD R9) is an autosomal recessive muscle disease for which there is currently no causative treatment. The development of putative therapies requires sensitive outcome measures for clinical t

Externí odkaz: https://doaj.org/article/8b6e15b896ea41baaac336a6d6cf25b8

Semi-Automated Analysis of Diaphragmatic Motion with Dynamic Magnetic Resonance Imaging in Healthy Controls and Non-Ambulant Subjects with Duchenne Muscular Dystrophy

Autor: Courtney A. Bishop, Valeria Ricotti, Christopher D. J. Sinclair, Matthew R. B. Evans, Jordan W. Butler, Jasper M. Morrow, Michael G. Hanna, Paul M. Matthews, Tarek A. Yousry, Francesco Muntoni, John S. Thornton, Rexford D. Newbould, Robert L. Janiczek

Publikováno v: Frontiers in Neurology, Vol 9 (2018)

Subjects with Duchenne Muscular Dystrophy (DMD) suffer from progressive muscle damage leading to diaphragmatic weakness that ultimately requires ventilation. Emerging treatments have generated interest in better characterizing the natural history of

Externí odkaz: https://doaj.org/article/637ffdccfc304b66b7187a719eee9dc0

Frailty among older adults and its distribution in England

Autor: D R, Sinclair, A, Maharani, T, Chandola, P, Bower, B, Hanratty, J, Nazroo, T W, O'Neill, G, Tampubolon, C, Todd, R, Wittenberg, F E, Matthews, N, Pendleton

Publikováno v: Sinclair, D, Maharani, A, Chandola, T, Bower, P, Hanratty, B, Nazroo, J, O'Neill, T, Tampubolon, G, Todd, C, Wittenberg, R, Matthews, F & Pendleton, N 2021, ' Frailty among Older Adults and Its Distribution in England ', The Journal of Frailty & Aging, pp. 1-6 . https://doi.org/10.14283/jfa.2021.55

Background: Information on the spatial distribution of the frail population is crucial to inform service planning in health and social care. Objectives: To estimate small-area frailty prevalence among older adults using survey data. To assess whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a18ca020f5e94f1435974cb9e3ca29b
http://eprints.lse.ac.uk/113854/

Upper Limb Evaluation in Duchenne Muscular Dystrophy: Fat-Water Quantification by MRI, Muscle Force and Function Define Endpoints for Clinical Trials.

Autor: Valeria Ricotti, Matthew R B Evans, Christopher D J Sinclair, Jordan W Butler, Deborah A Ridout, Jean-Yves Hogrel, Ahmed Emira, Jasper M Morrow, Mary M Reilly, Michael G Hanna, Robert L Janiczek, Paul M Matthews, Tarek A Yousry, Francesco Muntoni, John S Thornton

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162542 (2016)

A number of promising experimental therapies for Duchenne muscular dystrophy (DMD) are emerging. Clinical trials currently rely on invasive biopsies or motivation-dependent functional tests to assess outcome. Quantitative muscle magnetic resonance im

Externí odkaz: https://doaj.org/article/19bd8f41fda140849f988d7494cfbc4e

MR Neurography: Advances

Autor: Avneesh Chhabra, Lianxin Zhao, John A. Carrino, Eo Trueblood, Saso Koceski, Filip Shteriev, Lionel Lenkinski, Christopher D. J. Sinclair, Gustav Andreisek

Publikováno v: Radiology Research and Practice, Vol 2013 (2013)

High resolution and high field magnetic resonance neurography (MR neurography, MRN) is shown to have excellent anatomic capability. There have been considerable advances in the technology in the last few years leading to various feasibility studies u

Externí odkaz: https://doaj.org/article/d08460fb0072420eaeafe617b458d483