Zobrazeno 1 - 10
of 130
pro vyhledávání: '"D A Sanan"'
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 5, Pp 1002-1013 (1997)
The cellular location of hepatic lipase was investigated in transgenic rabbits that expressed human hepatic lipase in the liver. The binding of monoclonal antibodies to human hepatic lipase, as detected by either fluorescence-tagged or gold-conjugate
Externí odkaz:
https://doaj.org/article/0e1f3170ba574bc78607ee124d2fe5f1
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 3, Pp 583-592 (1995)
Heparan sulfate proteoglycans (HSPG) are involved in the binding and uptake of apolipoprotein (apo) E-enriched remnant lipoproteins by cultured cells in vitro. To define the role of hepatic HSPG in remnant lipoprotein clearance in vivo, heparinase (3
Externí odkaz:
https://doaj.org/article/c7554bbd0574483389c5ef3a8c7831cc
Autor:
Helen H. Hobbs, Vincent Mooser, Robert E. Hammer, D. A. Sanan, D. L. Newland, R. Tao, Juan Wang, S. Marcovina
Publikováno v:
Proceedings of the National Academy of Sciences. 95:4544-4549
We have generated mice with markedly elevated plasma levels of human low density lipoprotein (LDL) and reduced plasma levels of high density lipoprotein. These mice have no functional LDL receptors [ LDLR −/− ] and express a human apolipoprotein
Publikováno v:
Journal of Cutaneous Pathology. 24:499-506
Increasing evidence suggests involvement of integrins and CD44 isoforms in the pathogenesis of psoriasis, contributing to uncontrolled keratinocyte proliferation, neovascularization, and invasion of inflammatory cells. We have analyzed immunohistoche
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology, vol 132, iss 1-2
The Journal of cell biology, vol 132, iss 1-2
Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in intracel
Publikováno v:
Journal of Clinical Investigation. 96:1987-2001
The mechanism by which pleural mesothelial cells, the likely progenitor cells of asbestos-induced mesothelioma, recognize and internalize crocidolite asbestos is unknown. Because incubation of asbestos fibers with serum increases their association wi
Publikováno v:
The Journal of biological chemistry. 275(41)
Amyloid Abeta deposition is a neuropathologic hallmark of Alzheimer's disease. Activated microglia are intimately associated with plaques and appear to facilitate Abeta deposition, an event believed to contribute to pathogenesis. It is unclear if mic
Publikováno v:
The Journal of biological chemistry. 272(36)
Transgenic rabbits were produced that expressed high plasma levels (30-70 mg/dl) of human apolipoprotein (apo) E2(Cys-158), an apoE variant associated with the human genetic disorder type III hyperlipoproteinemia (HLP). Male transgenic rabbits fed no
Publikováno v:
Infection and immunity. 64(8)
Group B Neisseria meningitidis causes systemic disease, including meningitis, after initial colonization and subsequent penetration of nasopharyngeal mucosa, a tissue which is richly populated by macrophages. In an initial effort to characterize the
Publikováno v:
The journal of investigative dermatology. Symposium proceedings. 1(1)
The skin is not only the organ for the photosynthesis of vitamin D3, but also a target tissue for its activated form 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Vitamin D3 is absolutely essential for the development and maintenance of a healthy skeleton.