Zobrazeno 1 - 10
of 38
pro vyhledávání: '"D A Flockhart"'
Autor:
Pengyue Zhang, Lang Li, Zeruesenay Desta, Jon Duke, Sara K. Quinney, D. A. Flockhart, Jeffrey S. Elmendorf, Z. Wang, Xu Han
Publikováno v:
Clinical Pharmacology and Therapeutics
Myopathy is a group of muscle diseases that can be induced or exacerbated by drug–drug interactions (DDIs). We sought to identify clinically important myopathic DDIs and elucidate their underlying mechanisms. Five DDIs were found to increase the ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd3726ea651c89e00fbb57adc7eb515
http://europepmc.org/articles/PMC4664558
http://europepmc.org/articles/PMC4664558
Autor:
Sara K. Quinney, D. A. Flockhart, Warren B. Bilker, Colleen M. Brensinger, Hedi Schelleman, Lang Li, Xu Han, Sean Hennessy
Publikováno v:
British Journal of Clinical Pharmacology. 78:639-648
Aims To examine whether initiation of fibrates or statins in sulfonylurea users is associated with hypoglycaemia, and examine in vitro inhibition of cytochrome P450 (CYP) enzymes by statins, fenofibrate and glipizide. Methods We used healthcare data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12c50c98f7d81b85ea334bb6cf97dceb
https://doi.org/10.1111/bcp.12353
https://doi.org/10.1111/bcp.12353
Autor:
Scott E. Kasner, Cristin P Freeman, Charles E. Leonard, Warren B. Bilker, Stephen E. Kimmel, Colleen M. Brensinger, D. A. Flockhart, Sean Hennessy
Background and Purpose— There is controversy and little information about whether individual proton pump inhibitors (PPIs) differentially alter the effectiveness of clopidogrel in reducing ischemic stroke risk. We, therefore, aimed to elucidate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee10948f74c8adb6a9fe52e965c35b8
https://europepmc.org/articles/PMC4342326/
https://europepmc.org/articles/PMC4342326/
Autor:
Yoon K. Loke, D. A. Flockhart, Andrew J. Webb, Sarah Ross, Adam F. Cohen, Anthonius de Boer, Albert Ferro, Andrew A. Somogyi, Annette Gilchrist, Geoff Isbister
Publikováno v:
British Journal of Clinical Pharmacology. 81:6-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cffe0164636658cfd171ec5e877e64d2
https://doi.org/10.1111/bcp.12865
https://doi.org/10.1111/bcp.12865
Publikováno v:
Drug Metabolism and Disposition. 30:336-343
Metoclopramide is increasingly prescribed for conditions previously treated with cisapride, but its metabolic enzymology and drug interactions are poorly understood. Using human liver microsomes (HLMs) and recombinant human cytochromes P450 (P450), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbc5f395e5d9da5577142580d6bc3b0
https://doi.org/10.1124/dmd.30.3.336
https://doi.org/10.1124/dmd.30.3.336
Autor:
Vinod Rustgi, D. A. Flockhart, Gustavo Marino, Jeffrey S. Plotkin, Paul C. Kuo, Lynt B. Johnson, G. Salzberg
Publikováno v:
Alimentary Pharmacology & Therapeutics. 16:235-242
Background: Hepapoietin is a naturally occurring cytokine that promotes hepatocyte growth. Animal studies have suggested that hepapoietin and hepatocyte growth factor have a potential role in the prevention and management of liver diseases. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e67402e38262825ffd4f8d2fa98179dc
https://doi.org/10.1046/j.1365-2036.2002.01110.x
https://doi.org/10.1046/j.1365-2036.2002.01110.x
Autor:
W J Lu, D A Flockhart
Publikováno v:
Clinical pharmacology and therapeutics. 95(2)
Immense strides toward improved human genomic sequencing have been made over the past decade, but significant obstacles to clinical research and translation are now evident. Novel approaches able to traverse financial, regulatory, and ethical obstacl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e564de7e1025981e1af65ee9135d4d
https://pubmed.ncbi.nlm.nih.gov/24448457
https://pubmed.ncbi.nlm.nih.gov/24448457
Autor:
Adam F. Cohen, D. A. Flockhart, Yoon K. Loke, Andrew A. Somogyi, James M. Ritter, Albert Ferro
Publikováno v:
British Journal of Clinical Pharmacology. 79:4-5
During 2014 BJCP published 87 reviews (seven of which were meta-analyses and 17 systematic reviews, 15 were commissioned and 20 uncommissioned, 11 were themed), one short communication, one viewpoint, one set of abstracts, one historical perspective,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31eb1dde10deced6c39ae41224b9664
https://doi.org/10.1111/bcp.12551
https://doi.org/10.1111/bcp.12551
Publikováno v:
Alimentary pharmacologytherapeutics. 16(2)
Hepapoietin is a naturally occurring cytokine that promotes hepatocyte growth. Animal studies have suggested that hepapoietin and hepatocyte growth factor have a potential role in the prevention and management of liver diseases. However, human studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51d9669d8f38a881612b715cfd1655de
https://pubmed.ncbi.nlm.nih.gov/11860406
https://pubmed.ncbi.nlm.nih.gov/11860406
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(3)
We used expression microarrays to test the effects of rifampin on the overall pattern of mRNA expression of multiple metabolic enzymes in primary human hepatocytes. Two microarrays were utilized, a cDNA-based array and one that is oligonucleotide-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::342b9152925c6e7563cdbe3aebabc5e2
https://pubmed.ncbi.nlm.nih.gov/11714868
https://pubmed.ncbi.nlm.nih.gov/11714868