MC3R links nutritional state to childhood growth and the timing of puberty

Autor: Anthony P. Coll, MN Bedenbaugh, DT Porter, David H. Rowitch, John R. B. Perry, D A van Heel, X Dai, Rachel N. Lippert, Debra Rimmington, A. L. Gonçalves Soares, Felix R. Day, Duckett K, Patrick Sweeney, Zhaoyang Xu, Ahsan Nabi Khan, Hilary C. Martin, John Tadross, Roger D. Cone, Brian Y.H. Lam, Klj Ellacott, Richard B. Simerly, J Rosmaninho-Salgado, Alice E. Williamson, Gkc Dowsett, Sarah Finer, Irene Cimino, Giles S.H. Yeo, Audrey Melvin, Kara Rainbow, Claudia Langenberg, Stephen O'Rahilly, Nicholas J. Wareham, Katherine Ridley, Richard C. Trembath, Staffan Holmqvist, Sophie Buller, N J Timpson, Kaitlin H Wade, Ken K. Ong, Elena G. Bochukova

Publikováno v: Nature
2021, ' MC3R links nutritional state to childhood growth and the timing of puberty ', Nature, vol. 599, no. 7885, pp. 436-441 . https://doi.org/10.1038/s41586-021-04088-9

The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development1. The central melanocortin system acts through melanocortin 4 receptor (MC4R) to con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2690bb58b6dc1e9ea01491ecfdde0e49
https://doi.org/10.1038/s41586-021-04088-9

Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease

Autor: Robert P. Anderson, D A van Heel, Derek P. Jewell, Jason A. Tye-Din, Adrian V. S. Hill

BACKGROUND: Coeliac disease (CD) is due to an inappropriate T cell mediated response to specific gluten peptides. Measured by interferon gamma (IFN-gamma) ELISPOT, about half of the gliadin specific T cells induced with in vivo wheat gluten exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a3e7a43ff79ddc0aa1f7be30e41665
https://ora.ox.ac.uk/objects/uuid:32def893-6ed7-432a-bfa4-51992890244d

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappa B signalling

Autor: Donatella Barisani, Chris J. J. Mulder, Graham A. Heap, M.L. Mearin, Jihane Romanos, Cisca Wijmenga, Fiona M. Stevens, Gosia Trynka, Marcel Bruinenberg, David S Sanders, Graham Turner, Peter D. Howdle, Valerie Trimble, D A van Heel, Lude Franke, Wieke H. M. Verbeek, Dermot Kelleher, Alexandra Zhernakova, C. G. F. de Kovel, Karen A. Hunt, Geoffrey Holmes, Ross McManus, Julian R.F. Walters, Anthony W. Ryan, Maria Teresa Bardella, Mathieu Platteel

Publikováno v: Gut, 58(8), 1078-1083. BMJ PUBLISHING GROUP
Gut, 58(8), 1078-1083. BMJ Publishing Group
Trynka, G, Zhernakova, A, Romanos, J, Franke, L, Hunt, K A, Turner, G A, Bruinenberg, M, Heap, G A, Platteel, M, Ryan, A, de Kovel, C, Holmes, G K, Howdle, P D, Walters, J R, Sanders, D S, Mulder, C J J, Mearin, M L, Verbeek, W H M, Trimble, V, Stevens, F M, Kelleher, D, Barisani, D, Bardella, M T, McManus, R, van Heel, D A & Wijmenga, C 2009, ' Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling ', Gut, vol. 58, no. 8, pp. 1078-1083 . https://doi.org/10.1136/gut.2008.169052

Objective: Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci, we selected 458 single nucleotide p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a9a47ea484a5fd189881669ead05c
https://research.rug.nl/en/publications/b6294c0a-13e6-4178-902b-0f5cb27ab25d

Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitisAn unusual case of ascites

Autor: A.A. van Bodegraven, R. K. Linskens, Geoffrey Holmes, D A van Heel, Gerard Dijkstra, Rinse K. Weersma, Peter D. Howdle, Cisca Wijmenga, Martin C. Wapenaar, Chris J. J. Mulder, Marianna Bevova, Alienke J. Monsuur

Publikováno v: Gut. 57:463-467

Background: Celiac disease (GSE) and inflammatory bowel disease (IBD) are common gastrointestinal disorders. Both display enhanced intestinal permeability, initiated by gluten exposure (GSE) or bacterial interactions (IBD). Previous studies showed as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::204e4f53df68da7e0c63f82d6292cd7d
https://doi.org/10.1136/gut.2007.133132

High resolution MIC genotyping: Design and application to the investigation of inflammatory bowel disease susceptibility

Autor: Derek P. Jewell, K. Mulcahy-Hawes, Martin Barnardo, D A Van Heel, Tariq Ahmad, T R Orchard, Kenneth I. Welsh, Sara E. Marshall, Alessandro Armuzzi, Matt J. Neville, Jonathan Crawshaw, Michael Bunce

Publikováno v: Tissue Antigens. 60:164-179

The highly polymorphic nonclassical MHC class I chain-related (MIC) genes MICA and MICB encode stress inducible glycoproteins expressed on a variety of epithelial cells including intestinal cells. Interaction with the receptor NKG2D is likely to prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76bdd524d33fa0317a31b62c65930d41
https://doi.org/10.1034/j.1399-0039.2002.600207.x