The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile

Autor: Emile Auria, Lise Hunault, Patrick England, Marc Monot, Juliana Pipoli Da Fonseca, Mariette Matondo, Magalie Duchateau, Yannick D. N. Tremblay, Bruno Dupuy

Publikováno v: npj Biofilms and Microbiomes, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract The ability of bacterial pathogens to establish recurrent and persistent infections is frequently associated with their ability to form biofilms. Clostridioides difficile infections have a high rate of recurrence and relapses and it is hypot

Externí odkaz: https://doaj.org/article/a7840597db23437fb7f4235ea521a8d4

Oncology clinical trial disruption during the COVID-19 pandemic: a COVID-19 and cancer outcomes study

Autor: Z, Bakouny, C, Labaki, S, Bhalla, A L, Schmidt, J A, Steinharter, J, Cocco, D A, Tremblay, M M, Awad, A, Kessler, R I, Haddad, M, Evans, F, Busser, M, Wotman, C R, Curran, B S, Zimmerman, G, Bouchard, T, Jun, P V, Nuzzo, Q, Qin, L, Hirsch, J, Feld, K M, Kelleher, D, Seidman, H, Huang, H M, Anderson-Keightly, T, El Zarif, S Abou, Alaiwi, C, Champagne, T D, Rosenbloom, P S, Stewart, B E, Johnson, Q, Trinh, S M, Tolaney, M D, Galsky, T K, Choueiri, D B, Doroshow

Publikováno v: Annals of Oncology. 33:836-844

COVID-19 disproportionately impacted patients with cancer as a result of direct infection, and delays in diagnosis and therapy. Oncological clinical trials are resource-intensive endeavors that could be particularly susceptible to disruption by the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b4282fde15ec83b80eb63c3f9addfa
https://doi.org/10.1016/j.annonc.2022.04.071

c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile

Autor: Johann Peltier, Roland Seifert, Nicholas DiBenedetto, Pamela Altamirano-Silva, Audrey Hamiot, Bruno Dupuy, Olga Soutourina, Lynn Bry, Yannick D. N. Tremblay, Marine Oberkampf, Paula Bellés-Sancho

To cause disease, the important human enteropathogen Clostridioides difficile must colonize the gastro-intestinal tract but little is known on how this organism senses and responds to the harsh host environment to adapt and multiply. Nucleotide secon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8018860e27b46025fe92344d70844ced
https://doi.org/10.1101/2021.08.23.457418

Metabolic adaption to extracellular pyruvate triggers biofilm formation inClostridioides difficile

Autor: Marine Oberkampf, Bruno Dupuy, Benjamin A.R. Durand, Audrey Hamiot, Yannick D. N. Tremblay, Marc Monot, Isabelle Martin-Verstraete

Clostridioides difficileinfections are associated with gut microbiome dysbiosis and are the leading cause of hospital acquired diarrhoea. The infectious process is strongly influenced by the microbiota and successful infection relies on the absence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de43f9187fcd0b83e309044a991408f9
https://doi.org/10.1101/2021.01.23.427917

A microbiota-generated bile salt induces biofilm formation in Clostridium difficile

Autor: Yannick D. N. Tremblay, Thomas Dubois, Romain Briandet, Marc Monot, Julien Deschamps, Audrey Hamiot, Isabelle Martin-Verstraete, Bruno Dupuy

Publikováno v: npj Biofilms and Microbiomes
npj Biofilms and Microbiomes, [London?]: Springer Nature published in partnership with Nanyang Technological University, 2019, 5 (1), ⟨10.1038/s41522-019-0087-4⟩
npj Biofilms and Microbiomes 1 (5), . (2019)
npj Biofilms and Microbiomes, 2019, 5 (1), ⟨10.1038/s41522-019-0087-4⟩
npj Biofilms and Microbiomes, Vol 5, Iss 1, Pp 1-12 (2019)
NPJ Biofilms and Microbiomes

Clostridium difficile is a major cause of nosocomial infections. Bacterial persistence in the gut is responsible for infection relapse; sporulation and other unidentified mechanisms contribute to this process. Intestinal bile salts cholate and deoxyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6f9b8258b9c36267ff3d6ecf74fd45
https://hal.inrae.fr/hal-03031189