Zobrazeno 1 - 10
of 41
pro vyhledávání: '"D A, Sibarov"'
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 16:29-37
Publikováno v:
Journal of Evolutionary Biochemistry and Physiology. 57:694-703
Tricyclic antidepressants, specifically amitriptyline (ATL) and desipramine (DES) are currently used to treat depression and chronic pain of various origins, in which NMDA receptor dysfunctions play an important role. The effect of therapeutic ATL co
Publikováno v:
Biophysics. 65:88-94
—Pathological changes in the cerebellum are often associated with dysfunction of Purkinje cells, which is manifested in excessive spike activity. In our experiments, the increase in the frequency of spike activity of Purkinje cells was caused by th
Publikováno v:
Neuroscience and Behavioral Physiology. 50:115-118
Despite the fact that cultures of cerebellar granule cells constitute a popular experimental model, the key functional element of the cerebellum, i.e., Purkinje cells (PC), are rarely studied in tissue culture. There are currently serious methodologi
Autor:
M. A. Ivanova, Sergei M. Antonov, T. V. Karelina, P. A. Abushik, L. S. Sitnikova, D. A. Sibarov
Publikováno v:
Neuroscience and Behavioral Physiology. 49:1096-1099
Activation of cyclic adenosine monophosphate (cAMP) synthesis is known to lead to triggering of neuroprotective signal cascades. It is therefore interesting to assess the effects of forskolin as an activator of adenylate cyclase and cAMP production o
Publikováno v:
BMC Neuroscience, Vol 19, Iss 1, Pp 1-9 (2018)
BMC Neuroscience
BMC Neuroscience
Background The plasma membrane Na+/Ca2+-exchanger (NCX) has recently been shown to regulate Ca2+-dependent N-methyl-d-aspartate receptor (NMDAR) desensitization, suggesting a tight interaction of NCXs and NMDARs in lipid nanoclasters or “rafts”.
Autor:
D. A. Sibarov, Sergei M. Antonov
Publikováno v:
Biochemistry (Moscow). 83:1173-1183
Glutamate receptors play the key role in excitatory synaptic transmission in the central nervous system (CNS). N-methyl-D-aspartate-activated glutamate receptors (NMDARs) are ion channels permeable to sodium, potassium, and calcium ions that localize
Autor:
T. V. Karelina, P. A. Abushik, L. S. Sitnikova, Sergei M. Antonov, Yu. D. Stepanenko, Rashid Giniatullin, D. A. Sibarov, M. A. Ivanova
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 12:360-368
Using fluorescence detection methods, neurotoxic effects of L-homocysteine (HCY), L-glutamate (Glu), and N-methyl-D-aspartate (NMDA) on primary culture of rat cerebellar neurons were compared and the agonist-evoked intracellular Ca2+ responses and ch
Autor:
P. A. Abushik, Yu. D. Stepanenko, L. S. Sitnikova, D. A. Sibarov, M. A. Ivanova, T. V. Karelina, Sergei M. Antonov
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 12:390-393
The analysis of neuronal viability of cerebellar neurons in primary culture during long-lasting (240 min) treatment with glutamate revealed that forskolin (1 μM), an adenylate cyclase activator, prevents apoptosis and necrosis of cells, thus exhibit
Autor:
Maria A. Ivanova, Sergei M. Antonov, Arina D. Kokorina, T. V. Karelina, Polina D. Timofeeva, P. A. Abushik, Julia D. Stepanenko, D. A. Sibarov
Publikováno v:
Biomolecules, Vol 10, Iss 1104, p 1104 (2020)
Biomolecules
Volume 10
Issue 8
Biomolecules
Volume 10
Issue 8
Pathological homocysteine (HCY) accumulation in the human plasma, known as hyperhomocysteinemia, exacerbates neurodegenerative diseases because, in the brain, this amino acid acts as a persistent N-methyl-D-aspartate receptor agonist. We studied the