Zobrazeno 1 - 10
of 39
pro vyhledávání: '"D A, Nicoll"'
Autor:
Peter H Scanlon, John Stradling, Helen J. Lipinski, Dawn C. Groves, R H Mason, D J Nicoll, Sophie West
Publikováno v:
Diabetic Medicine. 27:423-430
Aims - To clarify the relationship between obstructive sleep apnoea (OSA) and diabetic retinopathy. Research design and methods A cohort of 240 men from primary and secondary care previously participated in a study on the prevalence of OSA in Type 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7269a3d08e3bb2d2057b0b7eebe559
https://doi.org/10.1111/j.1464-5491.2010.02962.x
https://doi.org/10.1111/j.1464-5491.2010.02962.x
Publikováno v:
American Journal of Physiology-Cell Physiology. 265:C748-C756
We used a panel of monoclonal antibodies raised against the canine cardiac Na(+)-Ca2+ exchanger expressed in Sf9 insect cells to analyze the immunoreactive domains and the topological organization of this membrane protein. Antibodies, which reacted s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbea98e09662ecd8b8745c2b87725cbb
https://doi.org/10.1152/ajpcell.1993.265.3.c748
https://doi.org/10.1152/ajpcell.1993.265.3.c748
Autor:
L. Weiler, D. A. Nicoll‐Griffith
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4037b131536eec771b35d479fe85c11
https://doi.org/10.1002/chin.199128239
https://doi.org/10.1002/chin.199128239
Autor:
N, Chauret, B, Dobbs, R L, Lackman, K, Bateman, D A, Nicoll-Griffith, D M, Stresser, J M, Ackermann, S D, Turner, V P, Miller, C L, Crespi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(9)
Recently, a novel nonfluorescent probe 3-[2-(N,N-diethyl-N-methylammonium)-ethyl]-7-methoxy-4-methylcoumarin (AMMC), which produces a fluorescent metabolite AMHC (3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin) was used with mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::774704df99b987261dcdbadd6bd67104
https://pubmed.ncbi.nlm.nih.gov/11502727
https://pubmed.ncbi.nlm.nih.gov/11502727
In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization
Autor:
J A, Yergey, L A, Trimble, J, Silva, N, Chauret, C, Li, M, Therien, E, Grimm, D A, Nicoll-Griffith
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
The metabolic profile of DFU [5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone], a potent and selective COX-2 inhibitor, was characterized using in vitro microsomal and hepatocyte incubations. A single product, corresponding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ae02be5946192129642e9eb96f499a7
https://pubmed.ncbi.nlm.nih.gov/11302928
https://pubmed.ncbi.nlm.nih.gov/11302928
Autor:
C, Li, N, Chauret, L A, Trimble, D A, Nicoll-Griffith, J M, Silva, D, MacDonald, H, Perrier, J A, Yergey, T, Parton, R P, Alexander, G J, Warrellow
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(3)
CDP-840 is a selective and potent phosphodiesterase type IV inhibitor, whose in vitro metabolism profile was first investigated using liver microsomes from different species. At least 10 phase I oxidative metabolites (M1-M10) were detected in the mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::458706185182beeba237821b1ff18b78
https://pubmed.ncbi.nlm.nih.gov/11181489
https://pubmed.ncbi.nlm.nih.gov/11181489
Autor:
D A, Nicoll-Griffith, J M, Silva, N, Chauret, S, Day, Y, Leblanc, P, Roy, J A, Yergey, R, Dixit, D, Patrick
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(2)
The drug candidate DFP [5,5-dimethyl-3-(2-isopropoxy)-4-(4-methanesulfonylphenyl)-2(5H)-furanone] is a selective cyclooxygenase-2 inhibitor under evaluation for analgesic and anti-inflammatory therapy. The in vitro metabolic pathways (rat microsomes)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a99b6f7881f73e5c08abc47b1d1b8acf
https://pubmed.ncbi.nlm.nih.gov/11159806
https://pubmed.ncbi.nlm.nih.gov/11159806
Autor:
D A, Nicoll-Griffith, J P, Falgueyret, J M, Silva, P E, Morin, L, Trimble, C C, Chan, S, Clas, S, Leger, Z, Wang, J A, Yergey, D, Riendeau
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(3)
The lactol derivative of a lactone cyclooxygenase-2 inhibitor (DFU) was evaluated in vivo and in vitro for its potential suitability as a prodrug. DFU-lactol was found to be 10 to 20 times more soluble than DFU in a variety of aqueous vehicles. After
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f8f2783de323674c3a280cc2620afa1
https://pubmed.ncbi.nlm.nih.gov/10064573
https://pubmed.ncbi.nlm.nih.gov/10064573
Autor:
J M, Silva, P E, Morin, S H, Day, B P, Kennedy, P, Payette, T, Rushmore, J A, Yergey, D A, Nicoll-Griffith
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(5)
Induction of cytochromes P450 (P450s) by drugs can lead to drug-drug interactions. Primary hepatocytes have been reported to retain inducible P450s. To optimize the use of primary hepatocytes for predicting induction of P450 (CYP 3A and 2B) expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91863dd662ec9e400eec13952c554ad8
https://pubmed.ncbi.nlm.nih.gov/9571231
https://pubmed.ncbi.nlm.nih.gov/9571231