Zobrazeno 1 - 10
of 2 384
pro vyhledávání: '"D A, Hill"'
Autor:
L. E. Burton, A. M. Haywood, J. C. Tindall, A. M. Dolan, D. J. Hill, E. L. McClymont, S. L. Ho, H. L. Ford
Publikováno v:
Climate of the Past, Vol 20, Pp 1177-1194 (2024)
We present the role of CO2 forcing in controlling Late Pliocene sea surface temperature (SST) change using six models from Phase 2 of the Pliocene Model Intercomparison Project (PlioMIP2) and palaeoclimate proxy data from the PlioVAR working group. A
Externí odkaz:
https://doaj.org/article/bbda1dfe238e40bdb3788ad4ce544ed4
Autor:
C. M. Aragon, D. F. Hill
Publikováno v:
Hydrology and Earth System Sciences, Vol 28, Pp 781-800 (2024)
This work introduces a novel snow metric, snow water storage (SwS), defined as the integrated area under the snow water equivalent (SWE) curve (units: length-time, e.g., m d). Unlike other widely used snow metrics that capture snow variables at a sin
Externí odkaz:
https://doaj.org/article/a978fd9d6f964758befe1c80ce0a7a3a
Autor:
Gavin P. Dowling, Sinead Toomey, Philip Bredin, Imelda Parker, Eibhlin Mulroe, Jacinta Marron, Olivia McLoughlin, Ausra Teiserskiene, Colm Power, Anne Marie O’Shea, Megan Greally, Patrick G. Morris, Deirdre Duke, Arnold D. K. Hill, Bryan T. Hennessy
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background The current standard of care in the neoadjuvant setting for high-risk HER2-positive (HER2 +) breast cancer is to combine systemic chemotherapy with dual HER2 blockade, trastuzumab and pertuzumab. Targeted therapies have significan
Externí odkaz:
https://doaj.org/article/525da2fab1674ea289c10763a6526868
Autor:
Sherlissa Ali-Thompson, Gordon R. Daly, Gavin P. Dowling, Conor Kilkenny, Luke Cox, Jason McGrath, Ma’en M. AlRawashdeh, Sindhuja Naidoo, Colm Power, Arnold D. K. Hill
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
AimThe overamplification of human epidermal growth factor (HER2) in breast cancer (BC) has been the subject of numerous research publications since its discovery in 1987. This is the first bibliometric analysis (BA) conducted on HER2-positive (HER2+)
Externí odkaz:
https://doaj.org/article/f147a5ddea4d468ab15878bf994f1c02
Autor:
Omar Mamad, Mona Heiland, Andreas U. Lindner, Thomas D. M. Hill, Ronan M. Ronroy, Kilian Rentrup, Amaya Sanz-Rodriguez, Elena Langa, Janosch P. Heller, Oscar Moreno, Jordi Llop, Anindya Bhattacharya, James A. Palmer, Marc Ceusters, Tobias Engel, David C. Henshall
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the P2X7 receptor antagonist JNJ-47
Externí odkaz:
https://doaj.org/article/4fa05e1ff28e4d35a32f692bc0e2ed81
Autor:
L. E. Burton, A. M. Haywood, J. C. Tindall, A. M. Dolan, D. J. Hill, A. Abe-Ouchi, W.-L. Chan, D. Chandan, R. Feng, S. J. Hunter, X. Li, W. R. Peltier, N. Tan, C. Stepanek, Z. Zhang
Publikováno v:
Climate of the Past, Vol 19, Pp 747-764 (2023)
Understanding the dominant climate forcings in the Pliocene is crucial to assessing the usefulness of the Pliocene as an analogue for our warmer future. Here, we implement a novel yet simple linear factorisation method to assess the relative influenc
Externí odkaz:
https://doaj.org/article/b2b940e11d494abcab1122986d68ab33
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Autor:
Elizabeth Brindley, Mona Heiland, Catherine Mooney, Mairead Diviney, Omar Mamad, Thomas D. M. Hill, Yan Yan, Morten T. Venø, Cristina R. Reschke, Aasia Batool, Elena Langa, Amaya Sanz-Rodriguez, Janosch P. Heller, Gareth Morris, Karen Conboy, Jørgen Kjems, Gary P. Brennan, David C. Henshall
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as blood. Experimental and human epilepsy are associated with altered brain and blood levels o
Externí odkaz:
https://doaj.org/article/5a12b88c05be4334969707b5a82ff1e7
Autor:
Nicola Cosgrove, Damir Varešlija, Stephen Keelan, Ashuvinee Elangovan, Jennifer M. Atkinson, Sinéad Cocchiglia, Fiona T. Bane, Vikrant Singh, Simon Furney, Chunling Hu, Jodi M. Carter, Steven N. Hart, Siddhartha Yadav, Matthew P. Goetz, Arnold D. K. Hill, Steffi Oesterreich, Adrian V. Lee, Fergus J. Couch, Leonie S. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The molecular landscape of breast cancer brain metastases (BCBM) is still understudied, especially for different breast cancer subtypes. Here, the authors characterise subtype-specific BCBMs using genomics and transcriptomics and identify homologous
Externí odkaz:
https://doaj.org/article/55e3acfd61844f0f8a60e2f4411af4cc
Autor:
Gavin P. Dowling, Stephen Keelan, Sinead Toomey, Gordon R. Daly, Bryan T. Hennessy, Arnold D. K. Hill
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
PurposeThe development of human epidermal growth factor receptor 2 (HER2)-directed therapies has revolutionized the treatment of HER2-positive breast cancer. The aim of this article is to review the continually evolving treatment strategies in the ne
Externí odkaz:
https://doaj.org/article/6a03b95135c141528bd2fbe1e3202046
Autor:
R. L. Crumley, D. F. Hill, K. Wikstrom Jones, G. J. Wolken, A. A. Arendt, C. M. Aragon, C. Cosgrove, Community Snow Observations Participants
Publikováno v:
Hydrology and Earth System Sciences, Vol 25, Pp 4651-4680 (2021)
A physically based snowpack evolution and redistribution model was used to test the effectiveness of assimilating crowd-sourced snow depth measurements collected by citizen scientists. The Community Snow Observations (CSO; https://communitysnowobs.or
Externí odkaz:
https://doaj.org/article/8ad3a5dee712410f90b38ae2a94017f3