Zobrazeno 1 - 10
of 465
pro vyhledávání: '"D A, Greene"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Morphological phenotyping of the mouse embryo is described at neurulation stages, primarily as a guide to evaluating the outcome of whole embryo cultures between embryonic days 8.5 and 9.5. During this period, neural tube closure is initiated and pro
Externí odkaz:
https://doaj.org/article/1e8ddda5518047f9bafa1038d10b6872
Autor:
Sarah Escuin, Saba Rose Raza-Knight, Dawn Savery, Carles Gaston-Massuet, Gabriel L. Galea, Nicholas D. E. Greene, Andrew J. Copp
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/b81ae88c324240baa87911da3f97606e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/c81c177fee2a43688728e80289173a17
Autor:
Gabriel L. Galea, Eirini Maniou, Timothy J. Edwards, Abigail R. Marshall, Ioakeim Ampartzidis, Nicholas D. E. Greene, Andrew J. Copp
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Mutations that cause tissue mosaicism have been identified in individuals with severe congenital defects. Here, the authors show that mosaic deletion of Vangl2 in the murine neuroepithlium causes spina bifida by preventing apical constriction via red
Externí odkaz:
https://doaj.org/article/52e4848101894d13b8f2a7a3e588a063
Autor:
Clara L. Essmann, Daniel Martinez-Martinez, Rosina Pryor, Kit-Yi Leung, Kalaivani Bala Krishnan, Prudence Pokway Lui, Nicholas D. E. Greene, André E. X. Brown, Vijay M. Pawar, Mandayam A. Srinivasan, Filipe Cabreiro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The development of reliable measures of health in ageing organisms is a need in ageing research. Using atomic force microscopy, here, the authors assess whole body stiffness of worms and show that it reflects organismal fitness.
Externí odkaz:
https://doaj.org/article/497f6a1f580e4f1db58b61849bc60df7
Autor:
Oleksandr Nychyk, Gabriel L. Galea, Matteo Molè, Dawn Savery, Nicholas D. E. Greene, Philip Stanier, Andrew J. Copp
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD). Some humans with NTDs also have PCP gene mu
Externí odkaz:
https://doaj.org/article/ccc95ab2bfa646f189a0558adb41caac
Autor:
Y. Choi, Y. Al-Mahmoud, J. Asciutto, B. Barnes, R. Bliton, C. Compton, W. Chang, X. Du, D. B. Greene, K. Holland, C. Magsig, S. Miller, H. Nguyen, L. Nguyen, L. Popielarski, M. Portillo, M. Reaume, K. Saito, B. Tousignant, R. Walker, J. Wenstrom, T. Xu
Publikováno v:
IEEE Transactions on Applied Superconductivity. 33:1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e23a400d1b067747897bd390f92e90f
https://doi.org/10.1109/tasc.2023.3244141
https://doi.org/10.1109/tasc.2023.3244141
Autor:
Xiaoyu Che, Jufen Liu, Gabriel L Galea, Yali Zhang, Nicholas D. E. Greene, Le Zhang, Lei Jin, Linlin Wang, Aiguo Ren, Zhiwen Li
Publikováno v:
Biology, Vol 11, Iss 9, p 1371 (2022)
Objective: Comorbid congenital malformation of multiple organs may indicate a shared genetic/teratogenic causality. Folic acid supplementation reduces the population-level prevalence of isolated neural tube defects (NTDs), but whether complex cases i
Externí odkaz:
https://doaj.org/article/864e559a49d34e9dab42d97298e73997
Autor:
Evanthia Nikolopoulou, Caroline S. Hirst, Gabriel Galea, Christina Venturini, Dale Moulding, Abigail R. Marshall, Ana Rolo, Sandra C. P. De Castro, Andrew J. Copp, Nicholas D. E. Greene
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Loss or over-expression of Grainyhead-like transcription factors (Grhl) prevents closure of the neural tube but the mechanism underlying this is unclear. Here, the authors show that Grhl2 regulates murine posterior-neuropore closure via changes in th
Externí odkaz:
https://doaj.org/article/997301dd14a44cfe8d45c82ba65c8e2b
Autor:
Shanshan Lin, Aiguo Ren, Linlin Wang, Chloe Santos, Yun Huang, Lei Jin, Zhiwen Li, Nicholas D. E. Greene
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)
Abstract Background Neural tube defects (NTDs) are common and severe congenital malformations. Pax3 is an essential gene for neural tube closure in mice but it is unknown whether altered expression or methylation of PAX3 contributes to human NTDs. We
Externí odkaz:
https://doaj.org/article/1fff2a3ba98d4998b9cd9e820f39384f