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Type 2B von Willebrand's disease in thirteen individuals from five unrelated Australian families: phenotype and genotype correlations

Autor: D A, Facey, E J, Favaloro, E, Maxwell, R, Baker, M S, Hertzberg

Publikováno v: American journal of hematology. 63(4)

Type 2B von Willebrand's disease (VWD) is due to a qualitative defect in von Willebrand factor (VWF) in which there is an increased affinity for the platelet glycoprotein Ib-IX-V receptor complex. Spontaneous binding of type 2B VWF to platelets and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a06741b3a6a46a85934705bd6c840883
https://pubmed.ncbi.nlm.nih.gov/10706763

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Structure and function of the von Willebrand factor A1 domain: analysis with monoclonal antibodies reveals distinct binding sites involved in recognition of the platelet membrane glycoprotein Ib-IX-V complex and ristocetin-dependent activation

Autor: M, De Luca, D A, Facey, E J, Favaloro, M S, Hertzberg, J C, Whisstock, T, McNally, R K, Andrews, M C, Berndt

Publikováno v: Blood. 95(1)

Binding of the adhesive glycoprotein, von Willebrand factor (vWf), to the platelet membrane glycoprotein (GP) Ib-IX-V complex initiates platelet adhesion and aggregation at high shear stress in hemostasis and thrombosis. In this study, the GP Ib-IX-V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fd2744dc0b93a518fc270637d731f0e
https://pubmed.ncbi.nlm.nih.gov/10607699

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