Výsledky vyhledávání - "D A, Casciano"

Antimutagenic activities of naturally occurring polyamines in Chinese hamster ovary cells in vitro

Autor: Renata Cozzi, Paolo Perticone, Roberta Bona, Stefania Polani, D. A. Casciano

Publikováno v: Environmental and Molecular Mutagenesis. 18:207-211

Spermine and spermidine, ubiquitous polyamines present in bacteria and animal cells, are also involved in cell growth. Since they interact with the double helix, they can stabilize the DNA molecule. Recent evidence of the antimutagenic and anticarcin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e718cb5066719ea82e31b14c80ddac94
https://doi.org/10.1002/em.2850180308

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Decreased in vitro interaction between p53 and nuclear stress proteins in the p53-deficient mouse

Autor: S M, Morris, J L, Pipkin, W G, Hinson, J G, Shaddock, W H, Tolleson, J F, Young, D A, Casciano

Publikováno v: Electrophoresis. 22(10)

In a previous study, the strength of the interaction between the nuclear stress proteins (sps) 25a, 70i, 72c, and 90 and the tumor suppressor protein p53 was determined by an in vitro fluorescence binding assay. The relative binding of the individual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbb5ec6dbf46ab399c90b46d411b17f9
https://pubmed.ncbi.nlm.nih.gov/11465510

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Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene

Autor: T, Chen, R A, Mittelstaedt, S D, Shelton, S B, Dass, M G, Manjanatha, D A, Casciano, R H, Heflich

Publikováno v: Environmental and molecular mutagenesis. 37(3)

In a previous study, we found that treating transgenic Big Blue rats with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) produced the same major DNA adduct in the target liver and the nontarget spleen lymphocytes and bone marrow cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f2dab9580c2e69a05d1cdd50b50ce0f
https://pubmed.ncbi.nlm.nih.gov/11317338

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Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats

Autor: T, Chen, R A, Mittelstaedt, A, Aidoo, L P, Hamilton, F A, Beland, D A, Casciano, R H, Heflich

Publikováno v: Environmental and molecular mutagenesis. 37(3)

N-Hydroxy-2-acetylaminofluorene (N-OH-AAF) is the proximate carcinogenic metabolite of the powerful rat liver carcinogen 2-acetylaminofluorene. In this study, transgenic Big Blue(R) rats were used to examine the relationship between in vivo mutagenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0b91d02d6edfb863e19f6e87ef013ba
https://pubmed.ncbi.nlm.nih.gov/11317337

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Aflatoxin B1-induced Hprt mutations in splenic lymphocytes of Fischer 344 rats. Results of an intermittent feeding trial

Autor: S M, Morris, A, Aidoo, J J, Chen, M W, Chou, D A, Casciano

Publikováno v: Mutation research. 423(1-2)

In a previous study, we found an increase in the mutant frequency at the Hypoxanthine phosphoribosyl transferase (Hprt) locus in the splenic lymphocytes of Fischer 344 rats acutely exposed to aflatoxin B1 (AFB1). Because an acute exposure may not ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b47da8914a02c136d557448244360c97
https://pubmed.ncbi.nlm.nih.gov/10029671

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Phenolphthalein induces micronuclei in transgenic human lymphoblastoid cells

Autor: M E, Bishop, A, Aidoo, O E, Domon, S M, Morris, D A, Casciano

Publikováno v: Environmental and molecular mutagenesis. 32(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::654014337b10c317b433002b9108e096
https://pubmed.ncbi.nlm.nih.gov/9814444

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Mutational response at the splenic T-lymphocyte hprt locus in mice treated as neonates: contrasting effects of the carcinogens N-ethyl-N-nitrosourea, dimethylnitrosamine, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Autor: S B, Dass, R H, Heflich, D A, Casciano

Publikováno v: Environmental and molecular mutagenesis. 31(3)

The newborn mouse tumorigenicity assay, which involves the treatment of animals during the first two weeks after birth and monitoring tumor induction after a year, has been suggested as a cost- and time-effective alternative to the conventional two-y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2489295a79dfec988013ed55fd0836f
https://pubmed.ncbi.nlm.nih.gov/9585262

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Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue rats

Autor: R A, Mittelstaedt, M G, Manjanatha, S D, Shelton, L E, Lyn-Cook, J B, Chen, A, Aidoo, D A, Casciano, R H, Heflich

Publikováno v: Environmental and molecular mutagenesis. 31(2)

An important question regarding the use of transgenic reporter genes to detect mutation in rodents is how the types of mutations recovered in transgenes compare with the types of mutations found in endogenous genes. In this study, we examined mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b7c2a731a869d2f82ca9fc826631ef2
https://pubmed.ncbi.nlm.nih.gov/9544192

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Genetic toxicology: impact on the next generation of toxicology

Autor: B A, Schwetz, D A, Casciano

Publikováno v: Environmental and molecular mutagenesis. 31(1)

In the early 1970s, we overestimated the range of applicability of the hypothesis that mutations were highly predictive of rodent cancer. Many substances that are nonmutagenesis in current screens are carcinogenic; some genotoxicants are not carcinog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05575eeb084f2dc5ad4690d011c3021b
https://pubmed.ncbi.nlm.nih.gov/9464309

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