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Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma

Autor: Hell, Tanja, Rutz, Adriano, Dürr, Lara, Dobrzyński, Maciej, Reinhardt, Jakob K, Lehner, Timo, Keller, Morris, John, Anika, Gupta, Mahabir, Pertz, Olivier, Hamburger, Matthias, Wolfender, Jean-Luc, Garo, Eliane

Publikováno v: Journal of natural products. 85(6)

The discovery of bioactive natural products remains a time-consuming and challenging task. The ability to link high-confidence metabolite annotations in crude extracts with activity would be highly beneficial to the drug discovery process. To address

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29020dbf0b606649546bd0536c072a52
https://pubmed.ncbi.nlm.nih.gov/35640148

High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma.

Autor: Dürr, Lara, Hell, Tanja, Dobrzyński, Maciej, Mattei, Alberto, John, Anika, Augsburger, Nathanja, Bradanini, Gloria, Reinhardt, Jakob K., Rossberg, Florian, Drobnjakovic, Milos, Gupta, Mahabir P., Hamburger, Matthias, Pertz, Olivier, Garo, Eliane, Dürr, Lara, Dobrzyński, Maciej

Publikováno v: Journal of Natural Products; 4/22/2022, Vol. 85 Issue 4, p1006-1017, 12p

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Methods for the discovery and characterization of octocoral terpene cyclases.

Autor: Burkhardt I; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, United States. Electronic address: iburkhardt@ucsd.edu., Dürr L; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, United States., Grayson NE; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, United States., Moore BS; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, United States.

Publikováno v: Methods in enzymology [Methods Enzymol] 2024; Vol. 699, pp. 343-371. Date of Electronic Publication: 2024 Mar 05.