Zobrazeno 1 - 10
of 2 065
pro vyhledávání: '"Dömling A."'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 950-958 (2024)
Tetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like characteristics of various molecules. Typically, tetrazoles are introduced from their nitrile precurso
Externí odkaz:
https://doaj.org/article/f69bf6c7f31f4a4c94fe093f600f7619
Autor:
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Dömling, Luis R. Domingo, Yaseen A. M. M. Elshaier
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
This study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention. The text includes th
Externí odkaz:
https://doaj.org/article/5d3a1efadfec43fd8edce7702b73e676
Autor:
Zefeng Wang, Shabnam Shaabani, Xiang Gao, Yuen Lam Dora Ng, Valeriia Sapozhnikova, Philipp Mertins, Jan Krönke, Alexander Dömling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Thalidomide and its analogs are molecular glues (MGs) that lead to targeted ubiquitination and degradation of key cancer proteins via the cereblon (CRBN) E3 ligase. Here, we develop a direct-to-biology (D2B) approach for accelerated discover
Externí odkaz:
https://doaj.org/article/f92198598a504265983f5dc2bc34f074
Autor:
Yuequ Zhang, Shabnam Shaabani, Kirsty Vowinkel, Marina Trombetta-Lima, Angélica María Sabogal-Guáqueta, Tingting Chen, Jan Hoekstra, Jan Lembeck, Martina Schmidt, Niels Decher, Alexander Dömling, Amalia M. Dolga
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116163- (2024)
Small conductance calcium-activated potassium (SK) channel activity has been proposed to play a role in the pathology of several neurological diseases. Besides regulating plasma membrane excitability, SK channel activation provides neuroprotection ag
Externí odkaz:
https://doaj.org/article/801196e2d22d464e8e87e27b4ea0434c
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract The SN2 nucleophilic substitution reaction is a vital organic transformation used for drug and natural product synthesis. Nucleophiles like cyanide, oxygen, nitrogen, sulfur, or phosphorous replace halogens or sulfonyl esters, forming new bo
Externí odkaz:
https://doaj.org/article/8c7c39542fac4d56b118ccd4bb6ab527
Autor:
Zhang, Yuequ, Shaabani, Shabnam, Vowinkel, Kirsty, Trombetta-Lima, Marina, Sabogal-Guáqueta, Angélica María, Chen, Tingting, Hoekstra, Jan, Lembeck, Jan, Schmidt, Martina, Decher, Niels, Dömling, Alexander, Dolga, Amalia M.
Publikováno v:
In Biomedicine & Pharmacotherapy February 2024 171
Autor:
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodríguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A. Holak, Ewa Surmiak
Publikováno v:
Molecules, Vol 29, Iss 12, p 2926 (2024)
In the published publication [...]
Externí odkaz:
https://doaj.org/article/07c96bba301f4128b33fe3b92feb0447
Autor:
Shamma Almuraikhy, Maha Sellami, Khaled Naja, Hadaia Saleh Al-Amri, Najeha Anwardeen, Amina Aden, Alexander Dömling, Mohamed A. Elrayess
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1182 (2024)
Aging is a fundamental biological process that progressively impairs the functionality of the bodily systems, leading to an increased risk of diseases. Telomere length is one of the most often used biomarkers of aging. Recent research has focused on
Externí odkaz:
https://doaj.org/article/1ffd32603f0d43b3823e6950abc103d5
Autor:
Gouridis, Giorgos, Muthahari, Yusran A., de Boer, Marijn, Griffith, Douglas A., Tsirigotaki, Alexandra, Tassis, Konstantinos, Zijlstra, Niels, Xu, Ruixue, Eleftheriadis, Nikolaos, Sugijo, Yovin, Zacharias, Martin, Dömling, Alexander, Karamanou, Spyridoula, Pozidis, Charalambos, Economou, Anastassios, Cordes, Thorben
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2021 Dec 01. 118(49), 1-12.
Externí odkaz:
https://www.jstor.org/stable/27094130
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