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Review

KUNSTPAUSEN. DIE TÖNE UND DIE STILLE Wolfgang Dömling

Autor: Becker, Peter

Publikováno v: Neue Zeitschrift für Musik (1991-), 2015 Jan 01. 176(1), 95-95.

Externí odkaz: https://www.jstor.org/stable/43799209

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Akademický článek

Innovative synthesis of drug-like molecules using tetrazole as core building blocks

Autor: Jingyao Li, Ajay L. Chandgude, Qiang Zheng, Alexander Dömling

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 950-958 (2024)

Tetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like characteristics of various molecules. Typically, tetrazoles are introduced from their nitrile precurso

Externí odkaz: https://doaj.org/article/f69bf6c7f31f4a4c94fe093f600f7619

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Akademický článek

Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery

Autor: Zefeng Wang, Shabnam Shaabani, Xiang Gao, Yuen Lam Dora Ng, Valeriia Sapozhnikova, Philipp Mertins, Jan Krönke, Alexander Dömling

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Thalidomide and its analogs are molecular glues (MGs) that lead to targeted ubiquitination and degradation of key cancer proteins via the cereblon (CRBN) E3 ligase. Here, we develop a direct-to-biology (D2B) approach for accelerated discover

Externí odkaz: https://doaj.org/article/f92198598a504265983f5dc2bc34f074

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Correction: Reyes Romero et al. Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein. Molecules 2022, 27 , 8282.

Autor: Reyes Romero, Atilio^1,2 (AUTHOR), Kubica, Katarzyna¹ (AUTHOR), Kitel, Radoslaw¹ (AUTHOR), Rodríguez, Ismael¹ (AUTHOR), Magiera-Mularz, Katarzyna¹ (AUTHOR), Dömling, Alexander² (AUTHOR), Holak, Tad A.¹ (AUTHOR) holak@chemia.uj.edu.pl, Surmiak, Ewa¹ (AUTHOR) holak@chemia.uj.edu.pl

Publikováno v: Molecules. Jun2024, Vol. 29 Issue 12, p2926. 1p.

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Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

Autor: Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Dömling, Luis R. Domingo, Yaseen A. M. M. Elshaier

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

This study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention. The text includes th

Externí odkaz: https://doaj.org/article/5d3a1efadfec43fd8edce7702b73e676

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Akademický článek

The isocyanide SN2 reaction

Autor: Pravin Patil, Qiang Zheng, Katarzyna Kurpiewska, Alexander Dömling

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)

Abstract The SN2 nucleophilic substitution reaction is a vital organic transformation used for drug and natural product synthesis. Nucleophiles like cyanide, oxygen, nitrogen, sulfur, or phosphorous replace halogens or sulfonyl esters, forming new bo

Externí odkaz: https://doaj.org/article/8c7c39542fac4d56b118ccd4bb6ab527

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