Výsledky vyhledávání - "Dóra Bojcsuk"

Akademický článek

The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2.

Autor: Borbála Vető, Dóra Bojcsuk, Caroline Bacquet, Judit Kiss, Szabolcs Sipeki, Ludovic Martin, László Buday, Bálint L Bálint, Tamás Arányi

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172020 (2017)

Hepatocyte nuclear factor 4 alpha (HNF4α) nuclear receptor is a master regulator of hepatocyte development, nutrient transport and metabolism. HNF4α is regulated both at the transcriptional and post-transcriptional levels by different mechanisms. S

Externí odkaz: https://doaj.org/article/9f357a00818a4974941222dd852dc047

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Agonist binding directs dynamic competition among nuclear receptors for heterodimerization with retinoid X receptor

Autor: Lina Fadel, Gabriele Müller, Dóra Bojcsuk, Laszlo Nagy, Éva Hegedüs, Bálint Rehó, Gergely Nagy, Katalin Tóth, Julianna Volkó, Gábor Szabó, Zsuzsanna Kolostyak, Zoltan Simandi, György Vámosi

Publikováno v: J Biol Chem

Retinoid X receptor (RXR) plays a pivotal role as a transcriptional regulator and serves as an obligatory heterodimerization partner for at least 20 other nuclear receptors (NRs). Given a potentially limiting/sequestered pool of RXR and simultaneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b52a097685322224209a3bb94b68f8
https://doi.org/10.1074/jbc.ra119.011614

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Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure

Autor: Timothy F. Osborne, Joshua S Smith, Adeline Divoux, Dóra Bojcsuk, Fanchao Yi, Balint L. Balint, Katalin Sandor, Meghan E. Hopf, Steven R. Smith

Publikováno v: Journal of the Endocrine Society

Background Preferential accumulation of fat in the upper body (apple shape) is associated with higher risk of developing metabolic syndrome relative to lower body fat (pear shape). We previously discovered that chromatin openness partially defined th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd76104a355c72b2c5348291b2fa73e
https://doi.org/10.1210/jendso/bvaa042

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Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes

Autor: Timothy F. Osborne, Adeline Divoux, Balint L. Balint, Dóra Bojcsuk, Amlan Talukder, Katalin Sandor, Xiaoman Li, Steven R. Smith

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-15 (2018)
Clinical Epigenetics

Background Increased lower body fat is associated with reduced cardiometabolic risk. The molecular basis for depot-specific differences in gluteofemoral (GF) compared with abdominal (A) subcutaneous adipocyte function is poorly understood. In the cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829c8c873618425b625f53d7e49f51ff
http://link.springer.com/article/10.1186/s13148-018-0582-0

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Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis

Autor: Harjit Pal Bhattoa, Ibolya Horváth, Beáta Bódi, András Vida, László Vígh, Péter Bai, Zsolt Török, Mária Péter, Laura Jankó, Dóra Bojcsuk, Judit Márton, Magdolna Szántó, Karen Uray, Zoltán Papp, Imre Gombos, Gábor Balogh, Balint L. Balint

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1863:1399-1412

There is a growing body of evidence that poly(ADP-ribose) polymerase-2 (PARP2), although originally described as a DNA repair protein, has a widespread role as a metabolic regulator. We show that the ablation of PARP2 induced characteristic changes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b65ed69080baa3f6d7813d04f4ce953
https://doi.org/10.1016/j.bbalip.2018.07.013

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Inducible super-enhancers are organized based on canonical signal-specific transcription factor binding elements

Autor: Dóra Bojcsuk, Gergely Nagy, Balint L. Balint

Publikováno v: Nucleic Acids Research

Super-enhancers are established through the interactions of several enhancers and a large number of proteins, including transcription factors and co-regulators; however, the formation of these interactions is poorly understood. By re-analysing previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab5e6e1cd0fbe3ef7da3ed89802bd02
http://europepmc.org/articles/PMC5397169

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Classification of different types of estrogen receptor alpha binding sites in MCF-7 cells

Autor: Balint L. Balint, Dóra Bojcsuk

Publikováno v: Journal of biotechnology. 299

Estrogen Receptor alpha (ERα) is a ligand-activated transcription factor and it has a prominent role in both physiological and pathological processes of the reproductive system. ERα has been investigated extensively in breast cancer and the MCF-7 b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a3e62452a3d515707173f9c8f85fdf
https://pubmed.ncbi.nlm.nih.gov/31039369

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Alternative super-enhancers result in similar gene expression in different tissues

Autor: Gergely Nagy, Dóra Bojcsuk, Balint L. Balint

Super-enhancers (SEs) are clusters of highly active enhancers, regulating cell type-specific and disease-related genes, including oncogenes. The individual regulatory regions within SEs might be simultaneously bound by different transcription factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6ead120eb06ec25b61487216c99fb2

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The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2

Autor: Ludovic Martin, Szabolcs Sipeki, Tamás Arányi, Borbála Vető, László Buday, Dóra Bojcsuk, Judit Kiss, Caroline Bacquet, Balint L. Balint

Publikováno v: Repositorio Universidad Regional Amazónica
Universidad Regional Amazónica
instacron:IKIAM
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0172020 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb874c30c51fb96cbff4d7b2d97c0d50
https://doi.org/10.1371/journal.pone.0172020

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Nuclear receptors in transgenerational epigenetic inheritance

Autor: Balint L. Balint, Dóra Bojcsuk, Edina Erdős, Lilla Ozgyin

Publikováno v: Progress in biophysics and molecular biology. 118(1-2)

Nuclear Receptors are ligand-activated transcription factors that translate information about the lipid environment into specific genetic programs, a property that renders them good candidates to be mediators of rapid adaptation changes of a species.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760d7331a4454d4e746d805e470cd517
https://pubmed.ncbi.nlm.nih.gov/25792088

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