Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.

Autor: Pinto-Fernandez A; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK. adan.pintofernandez@ndm.ox.ac.uk.; Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK. adan.pintofernandez@ndm.ox.ac.uk., Salio M; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK., Partridge T; Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Chen J; CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Vere G; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Greenwood H; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Olie CS; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Damianou A; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Scott HC; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Pegg HJ; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, NW1 0NH, UK., Chiarenza A; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, NW1 0NH, UK., Díaz-Saez L; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Smith P; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Gonzalez-Lopez C; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK., Patel B; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, NW1 0NH, UK., Anderton E; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, NW1 0NH, UK., Jones N; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, NW1 0NH, UK., Hammonds TR; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, NW1 0NH, UK., Huber K; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Muschel R; CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Borrow P; Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK., Cerundolo V; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK., Kessler BM; TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK. benedikt.kessler@ndm.ox.ac.uk.; Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK. benedikt.kessler@ndm.ox.ac.uk.

Publikováno v: British journal of cancer [Br J Cancer] 2021 Feb; Vol. 124 (4), pp. 817-830. Date of Electronic Publication: 2020 Nov 20.

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