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Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists.

Autor: Prieto-Díaz, Rubén, González-Gómez, Manuel, Fojo-Carballo, Hugo, Azuaje, Jhonny, El Maatougui, Abdelaziz, Majellaro, Maria, Loza, María I., Brea, José, Fernández-Dueñas, Víctor, Paleo, M. Rita, Díaz-Holguín, Alejandro, Garcia-Pinel, Beatriz, Mallo-Abreu, Ana, Estévez, Juan C., Andújar-Arias, Antonio, García-Mera, Xerardo, Gomez-Tourino, Iria, Ciruela, Francisco, Salas, Cristian O., Gutiérrez-de-Terán, Hugo

Publikováno v: Journal of Medicinal Chemistry; 1/12/2023, Vol. 66 Issue 1, p890-912, 23p

Front Cover: When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists (ChemMedChem 4/2023).

Autor: Díaz‐Holguín, Alejandro, Rashidian, Azam, Pijnenburg, Dirk, Monteiro Ferreira, Glaucio, Stefela, Alzbeta, Kaspar, Miroslav, Kudova, Eva, Poso, Antti, van Beuningen, Rinie, Pavek, Petr, Kronenberger, Thales

Publikováno v: ChemMedChem; 2/14/2023, Vol. 18 Issue 4, p1-1, 1p

Exploring the Effect of Halogenation in a Series of Potent and Selective A 2B Adenosine Receptor Antagonists.

Autor: Prieto-Díaz R; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, 75124Uppsala, Sweden., González-Gómez M; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Fojo-Carballo H; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Azuaje J; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., El Maatougui A; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Majellaro M; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Loza MI; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Brea J; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Fernández-Dueñas V; Pharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, 08907L'Hospitalet de Llobregat, Spain.; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, 08907L'Hospitalet de Llobregat, Spain., Paleo MR; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Díaz-Holguín A; Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, 75124Uppsala, Sweden., Garcia-Pinel B; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Mallo-Abreu A; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Estévez JC; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Andújar-Arias A; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., García-Mera X; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Gomez-Tourino I; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain., Ciruela F; Pharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, 08907L'Hospitalet de Llobregat, Spain.; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, 08907L'Hospitalet de Llobregat, Spain., Salas CO; Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago7820436, Chile., Gutiérrez-de-Terán H; Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, 75124Uppsala, Sweden., Sotelo E; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 890-912. Date of Electronic Publication: 2022 Dec 14.