Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease.

Autor: Rohde D; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.; These authors contributed equally: David Rohde, Katrien Vandoorne., Vandoorne K; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Biomedical Engineering Faculty, Technion-Israel Institute of Technology, Haifa, Israel.; These authors contributed equally: David Rohde, Katrien Vandoorne., Lee IH; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Grune J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Zhang S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., McAlpine CS; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Schloss MJ; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Nayar R; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Courties G; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Frodermann V; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Wojtkiewicz G; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Honold L; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Chen Q; Max Planck Institute for Molecular Biomedicine, Muenster, Germany., Schmidt S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Sun Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Cremer S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Hoyer FF; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Iborra-Egea O; Institut del Cor Germans Trias i Pujol, Barcelona, Spain., Muñoz-Guijosa C; Institut del Cor Germans Trias i Pujol, Barcelona, Spain., Ji F; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA., Zhou B; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Adams RH; Max Planck Institute for Molecular Biomedicine, Muenster, Germany., Wythe JD; Cardiovascular Research Institute, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Hidalgo J; Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Barcelona, Spain., Watanabe H; Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan., Jung Y; Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., van der Laan AM; Heart Center, Department of Cardiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Piek JJ; Heart Center, Department of Cardiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Kfoury Y; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Désogère PA; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA., Vinegoni C; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Dutta P; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sadreyev RI; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Caravan P; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA., Bayes-Genis A; Institut del Cor Germans Trias i Pujol, Barcelona, Spain., Libby P; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Scadden DT; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Lin CP; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan., Naxerova K; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Swirski FK; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Jan; Vol. 1 (1), pp. 28-44. Date of Electronic Publication: 2021 Dec 23.