Výsledky vyhledávání - "Désirée Schatton"

Akademický článek

CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

Autor: Désirée Schatton, Giada Di Pietro, Karolina Szczepanowska, Matteo Veronese, Marie-Charlotte Marx, Kristina Braunöhler, Esther Barth, Stefan Müller, Patrick Giavalisco, Thomas Langer, Aleksandra Trifunovic, Elena I Rugarli

Publikováno v: eLife, Vol 11 (2022)

Proliferating cells undergo metabolic changes in synchrony with cell cycle progression and cell division. Mitochondria provide fuel, metabolites, and ATP during different phases of the cell cycle, however it is not completely understood how mitochond

Externí odkaz: https://doaj.org/article/9ae815e02e694cba80408f4eb523b738

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CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

Autor: Matteo Veronese, Stefan Müller, Aleksandra Trifunovic, Patrick Giavalisco, Thomas Langer, Esther Barth, Elena I. Rugarli, Giada Di Pietro, Marie-Charlotte Marx, Kristina Braunöhler, Désirée Schatton, Karolina Szczepanowska

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc6efbac8222490599c109abac0c28f4
https://doi.org/10.1101/2021.10.20.465082

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CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

Publikováno v: Elife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bc6904662d274d69f38dd68246eff6
https://pubmed.ncbi.nlm.nih.gov/35559794

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Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L

Autor: Milica Jevtic, Désirée Schatton, S. M. V. Kochan, S. Chandragiri, Elisa Motori, Hans-Georg Sprenger, Elena I. Rugarli, K. Ndoci, Patrick Giavalisco, Thomas Langer, S. Mueller, Vignesh Sakthivelu, G. Wani, J. M. Seeger, R. J. Acton, Matteo Bergami

The transition between quiescence and activation in neural stem and progenitor cells (NSPCs) is coupled to reversible changes in energy metabolism with key implications for life-long NSPC self-renewal and neurogenesis. How this metabolic plasticity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68a156a3437704be32c14316655d12d1
https://doi.org/10.1101/2021.08.18.456709

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CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy

Autor: Salim Khiati, Marie-Charlotte Marx, Janica L Wiederstein, David Pla-Martín, Elena I. Rugarli, Désirée Schatton, Marcus Krüger

Publikováno v: The EMBO Journal

Mitochondria house anabolic and catabolic processes that must be balanced and adjusted to meet cellular demands. The RNA‐binding protein CLUH (clustered mitochondria homolog) binds mRNAs of nuclear‐encoded mitochondrial proteins and is highly exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92eed4c9850f53d958e4a0387c0309dc
https://doi.org/10.15252/embj.2019102731

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CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs

Autor: Teresa Corona, Vangelis Kondylis, David Pla-Martín, Alberto Pessia, Ivan Nemazanyy, Peter Zentis, Astrid Schauss, Vidya Velagapudi, Elena I. Rugarli, Esther Barth, Henriette Hansen, Marie-Charlotte Marx, Désirée Schatton, Arnaud Mourier

Publikováno v: The Journal of Cell Biology

CLUH binds mRNAs implicated in intermediate metabolism and oxidative phosphorylation, but the physiological and molecular significance of these interactions is unclear. Schatton et al. use new constitutive and liver-specific Cluh knockouts to define

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a43b8fcf41b0f9ae081a8db60ff108
http://europepmc.org/articles/PMC5350512

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A concert of RNA-binding proteins coordinates mitochondrial function

Autor: Désirée Schatton, Elena I. Rugarli

Publikováno v: Critical reviews in biochemistry and molecular biology. 53(6)

Mitochondria are dynamic and plastic organelles, which flexibly adapt morphology, ATP production, and metabolic function to meet extrinsic challenges and demands. Regulation of mitochondrial biogenesis is essential during development and in adult lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dec987ab4f52d169df2dcbbafe6d12
https://pubmed.ncbi.nlm.nih.gov/30741581

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Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration

Autor: Simon Hess, Elena I. Rugarli, Susanne Brodesser, Désirée Schatton, Steffen Hermans, Peter Kloppenburg, Esther Barth, Thomas Langer, Eva R. Almajan, Sara Murru

Publikováno v: Glia

Mitochondrial dysfunction causes neurodegeneration but whether impairment of mitochondrial homeostasis in astrocytes contributes to this pathological process remains largely unknown. The m‐AAA protease exerts quality control and regulatory function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353e19b5f5aa2c191603b661a2d87b38
https://pubmed.ncbi.nlm.nih.gov/30989755

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CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins

Autor: David Pla-Martín, Henriette Hansen, Janine Altmueller, Elena I. Rugarli, Désirée Schatton, Jie Gao, Peter Frommolt, Esther Barth, Paola Martinelli, Marco Sardiello, Christian Becker

Publikováno v: The Journal of Cell Biology

CLUH is a cytosolic mRNA-binding protein that specifically binds a subset of mRNAs encoding mitochondrial proteins and may regulate their localized translation.
Mitochondrial function requires coordination of two genomes for protein biogenesis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb098d6190d4293d35688fcf29ddd6ba
https://doi.org/10.1083/jcb.201403129

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