Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Désirée Goubert"'
Autor:
Federica Sarno, Désirée Goubert, Emilie Logie, Martijn G. S. Rutten, Mihaly Koncz, Christophe Deben, Anita E. Niemarkt, Lucia Altucci, Pernette J. Verschure, Antal Kiss, Wim Vanden Berghe, Marianne G. Rots
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 102 (2022)
Plasminogen activator, urokinase (PLAU) is involved in cell migration, proliferation and tissue remodeling. PLAU upregulation is associated with an increase in aggressiveness, metastasis, and invasion of several cancer types, including breast cancer.
Externí odkaz:
https://doaj.org/article/96a430b70388450ba692e106845876d2
Autor:
Rutger A. F. Gjaltema, Désirée Goubert, Christian Huisman, Consuelo del Pilar García Tobilla, Mihály Koncz, Pytrick G. Jellema, Dandan Wu, Uilke Brouwer, Antal Kiss, Pernette J. Verschure, Ruud A. Bank, Marianne G. Rots
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3634 (2020)
Epigenetic editing, an emerging technique used for the modulation of gene expression in mammalian cells, is a promising strategy to correct disease-related gene expression. Although epigenetic reprogramming results in sustained transcriptional modula
Externí odkaz:
https://doaj.org/article/5d79f594822e425a9a45ea409f5d9dc4
Publikováno v:
Advances in experimental medicine and biology. 1389
DNA methylation is an essential epigenetic mark, strongly associated with gene expression regulation. Aberrant DNA methylation patterns underlie various diseases and efforts to intervene with DNA methylation signatures are of great clinical interest.
Autor:
Consuelo Del Pilar García Tobilla, Christian Huisman, Antal Kiss, Marianne G. Rots, Rutger A. F. Gjaltema, Ruud A. Bank, Dan-Dan Wu, Désirée Goubert, Pytrick Jellema, Mihály Koncz, Pernette J. Verschure, Uilke Brouwer
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3634, p 3634 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 21(10):3634. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 21(10):3634. MDPI AG
Volume 21
Issue 10
Gjaltema, R A F, Goubert, D, Huisman, C, Del Pilar García Tobilla, C, Koncz, M, Jellema, P G, Wu, D, Brouwer, U, Kiss, A, Verschure, P J, Bank, R A & Rots, M G 2020, ' KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation ', International Journal of Molecular Sciences, vol. 21, no. 10, 3634 . https://doi.org/10.3390/ijms21103634
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 21(10):3634. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 21(10):3634. MDPI AG
Volume 21
Issue 10
Gjaltema, R A F, Goubert, D, Huisman, C, Del Pilar García Tobilla, C, Koncz, M, Jellema, P G, Wu, D, Brouwer, U, Kiss, A, Verschure, P J, Bank, R A & Rots, M G 2020, ' KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation ', International Journal of Molecular Sciences, vol. 21, no. 10, 3634 . https://doi.org/10.3390/ijms21103634
Epigenetic editing, an emerging technique used for the modulation of gene expression in mammalian cells, is a promising strategy to correct disease-related gene expression. Although epigenetic reprogramming results in sustained transcriptional modula
Publikováno v:
Methods in Molecular Biology ISBN: 9781493977734
Epigenome Editing
Methods in Molecular Biology
Methods in Molecular Biology-Epigenome Editing
Epigenome Editing: Methods and Protocols, 1767, 395-415
Epigenome Editing
Methods in Molecular Biology
Methods in Molecular Biology-Epigenome Editing
Epigenome Editing: Methods and Protocols, 1767, 395-415
Epigenetic editing is a promising approach to modulate the local chromatin environment of target genes with the ultimate goal of stable gene expression reprogramming. Epigenetic editing tools minimally consist of a DNA-binding domain and an effector
Publikováno v:
Convergent Science Physical Oncology
Convergent Science Physical Oncology, 3(1):013006
Convergent Science Physical Oncology, 3(1):013006
Recent developments in biotechnology have enabled scientists to modulate DNA sequences in a precise way. These genome engineering technologies also open new possibilities to alter the epigenetic composition of the genome at any given genomic location
Autor:
Irene H. Heijink, Tomasz P. Jurkowski, Marianne G. Rots, David Cano-Rodriquez, Machteld N. Hylkema, Désirée Goubert, Rutger A. F. Gjaltema, Melanie Winkle, Juan Song
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 312(3), L334-L347. AMER PHYSIOLOGICAL SOC
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology
Airway mucus hypersecretion contributes to the morbidity and mortality in patients with chronic inflammatory lung diseases. Reducing mucus production is crucial for improving patients’ quality of life. The transcription factor SAM-pointed domain–