Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Désirée Böck"'
Autor:
Désirée Böck, Dario Hüsler, Bernhard Steiner, João M. Medeiros, Amanda Welin, Katarzyna A. Radomska, Wolf-Dietrich Hardt, Martin Pilhofer, Hubert Hilbi
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Legionnaires’ disease is a life-threatening pneumonia, which is characterized by high fever, coughing, shortness of breath, muscle pains, and headaches. The disease is caused by the amoeba-resistant bacterium L. pneumophila
Externí odkaz:
https://doaj.org/article/58c72492c5834d36850e5b5fde327730
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2
Autor:
Kathi Ging, Lukas Frick, Johannes Schlachetzki, Andrea Armani, Yanping Zhu, Pierre-André Gilormini, Ashutosh Dhingra, Desirée Böck, Ana Marques, Matthew Deen, Xi Chen, Tetiana Serdiuk, Chiara Trevisan, Stefano Sellitto, Claudio Pisano, Christopher K. Glass, Peter Heutink, Jiang-An Yin, David J. Vocadlo, Adriano Aguzzi
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract Mutations in GBA1 encoding the lysosomal enzyme β-glucocerebrosidase (GCase) are among the most prevalent genetic susceptibility factors for Parkinson’s disease (PD), with 10–30% of carriers developing the disease. To identify genetic m
Externí odkaz:
https://doaj.org/article/4c0ae1d7d594437b8f6bf9199fd5b7f6
Autor:
Yanik Weber, Desirée Böck, Anastasia Ivașcu, Nicolas Mathis, Tanja Rothgangl, Eleonora I. Ioannidi, Alex C. Blaudt, Lisa Tidecks, Máté Vadovics, Hiromi Muramatsu, Andreas Reichmuth, Kim F. Marquart, Lucas Kissling, Norbert Pardi, Martin Jinek, Gerald Schwank
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Prime editing is a highly versatile genome editing technology that enables the introduction of base substitutions, insertions, and deletions. However, compared to traditional Cas9 nucleases prime editors (PEs) are less active. In this study
Externí odkaz:
https://doaj.org/article/0aff369579524b25ad7f5eb7c077ffae
Autor:
Médéric Diard, Judith A Bouman, Isabel Kolinko, Markus Furter, Wolf-Dietrich Hardt, Petra Geiser, Annika Hausmann, Dirk Bumann, Martin Pilhofer, Stefan A. Fattinger, Crispin M. Lang, Emma Slack, Erik Bakkeren, Désirée Böck, Roland R. Regoes, Mikael E. Sellin, Dorothée L. Berthold, Manja Barthel-Scherrer
Publikováno v:
Mucosal Immunology
Mucosal Immunology, 13 (3)
Mucosal Immunology, 13 (3)
Inflammasomes can prevent systemic dissemination of enteropathogenic bacteria. As adapted pathogens including Salmonella Typhimurium (S. Tm) have evolved evasion strategies, it has remained unclear when and where inflammasomes restrict their dissemin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d0bf2b03dcf022789a008510ec1197
Publikováno v:
Current Opinion in Microbiology. 43:62-68
Bacterium-host interactions are important for diverse ecological settings including pathogenicity and symbiosis. Electron cryotomography is a powerful method for studying the macromolecular complexes that mediate such interactions in situ. The main l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0756b3fb9c597077636cd271a4d50a70
https://doi.org/10.1016/j.mib.2017.12.006
https://doi.org/10.1016/j.mib.2017.12.006
Thein situ3-D organization of chromatin at the nucleosome and oligonucleosome levels is unknown. Here we use cryo-electron tomography (cryo-ET) to determine thein situstructures of HeLa nucleosomes, which have canonical core structures and asymmetric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2223513452dad131961ac7a941a7a4b9
Publikováno v:
Current opinion in structural biology. 52
The need for bacteria to interact with their environment has driven the evolution of elaborate secretion systems. By virtue of their function, secretion systems are macromolecular complexes associated with the cell envelope and therefore inherently d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae85e9af5dc4cf21350fdbbd69ff0fb4
https://pubmed.ncbi.nlm.nih.gov/30223223
https://pubmed.ncbi.nlm.nih.gov/30223223
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, 29 (20)
Molecular Biology of the Cell, 29 (20)
The in situ three-dimensional organization of chromatin at the nucleosome and oligonucleosome levels is unknown. Here we use cryo-electron tomography to determine the in situ structures of HeLa nucleosomes, which have canonical core structures and as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d26ae6a6565451c38a2d3cbab9a3a8
Publikováno v:
Ultramicroscopy
Ultramicroscopy, 190
Ultramicroscopy, 190
Electron cryotomography is able to visualize macromolecular complexes in their cellular context, in a frozen-hydrated state, and in three dimensions. The method, however, is limited to relatively thin samples. Cryo-focused ion beam (FIB) milling is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83eadf583489a2f37ee250cd96b7acff
Autor:
Thomas Penz, João M. Medeiros, Karin Aistleitner, Désirée Böck, Han-Fei Tsao, Martin Pilhofer, Matthias Horn, Gregor L. Weiss
Publikováno v:
Science
Science, 357 (6352)
Science, 357 (6352)
Identification of a new injection system To interact with other cells, bacteria use contractile machines that function similarly to membrane-puncturing bacteriophages. The so-called type 6 secretion system (T6SS) functions from inside a bacterial cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea1a0ed6f666fb465f7fd4669488b08