Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Décio L. Eizirik"'
Autor:
Jing Zhang, Yuan Zou, Longmin Chen, Fei Sun, Qianqian Xu, Qing Zhou, Yi Wang, Xi Luo, Na Wang, Yang Li, Shu Zhang, Fei Xiong, Ping Yang, Shiwei Liu, Tao Yang, Jianping Weng, Décio L. Eizirik, Jinhua Yan, Zhiguang Zhou, Cong-Yi Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The regulation of autoimmunity against pancreatic islet β cells for type 1 diabetes (T1D) onset is still unclear. NOD/ShiLtJ (NOD) mice are prone to the onset of autoimmune diabetes, but its congenic strain, ALR/Lt (ALR), is not. Here we sh
Externí odkaz:
https://doaj.org/article/cc350dba4cb4414d95558476e1cca79c
Autor:
Moisés Castellá, Albert Blasco-Roset, Marion Peyrou, Aleix Gavaldà-Navarro, Joan Villarroya, Tania Quesada-López, Leyre Lorente-Poch, Juan Sancho, Florian Szymczak, Anthony Piron, Sonia Rodríguez-Fernández, Stefania Carobbio, Albert Goday, Pere Domingo, Antonio Vidal-Puig, Marta Giralt, Décio L. Eizirik, Francesc Villarroya, Rubén Cereijo
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106847- (2023)
Summary: Adipose tissue from pheochromocytoma patients acquires brown fat features, making it a valuable model for studying the mechanisms that control thermogenic adipose plasticity in humans. Transcriptomic analyses revealed a massive downregulatio
Externí odkaz:
https://doaj.org/article/28b4ea636229492aaaac613396fa4a6a
Autor:
Federica Fantuzzi, Sanna Toivonen, Andrea Alex Schiavo, Heeyoung Chae, Mohammad Tariq, Toshiaki Sawatani, Nathalie Pachera, Ying Cai, Chiara Vinci, Enrico Virgilio, Laurence Ladriere, Mara Suleiman, Piero Marchetti, Jean-Christophe Jonas, Patrick Gilon, Décio L. Eizirik, Mariana Igoillo-Esteve, Miriam Cnop
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research. Here, we fully characterized iPSC-derived beta cell function in vitro and in vivo in humanized mice. U
Externí odkaz:
https://doaj.org/article/0801cd4a24f44be99a2985f1ef3ecd75
Autor:
Maikel L. Colli, Mireia Ramos-Rodríguez, Ernesto S. Nakayasu, Maria I. Alvelos, Miguel Lopes, Jessica L. E. Hill, Jean-Valery Turatsinze, Alexandra Coomans de Brachène, Mark A. Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgensen, Lorella Marselli, Piero Marchetti, Sarah J. Richardson, Noel G. Morgan, Thomas O. Metz, Lorenzo Pasquali, Décio L. Eizirik
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The cytokine IFNα is expressed in the islets of individuals with type 1 diabetes and contributes to local inflammation and destruction of beta cells. Here, the authors provide a global multiomics view of IFNα-induced changes in human beta cells at
Externí odkaz:
https://doaj.org/article/7ba57ffc94954c2897c0cf413d87e02a
Autor:
Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 367-375 (2018)
Background: Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of people with T1D and
Externí odkaz:
https://doaj.org/article/d2c64acf75394175ae0f41916579e6da
Autor:
Gabriela Bomfim Ferreira, An-Sofie Vanherwegen, Guy Eelen, Ana Carolina Fierro Gutiérrez, Leentje Van Lommel, Kathleen Marchal, Lieve Verlinden, Annemieke Verstuyf, Tatiane Nogueira, Maria Georgiadou, Frans Schuit, Décio L. Eizirik, Conny Gysemans, Peter Carmeliet, Lut Overbergh, Chantal Mathieu
Publikováno v:
Cell Reports, Vol 10, Iss 5, Pp 711-725 (2015)
Metabolic switches in various immune cell subsets enforce phenotype and function. In the present study, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), induces human monocyte-derived tolerogenic dendritic cel
Externí odkaz:
https://doaj.org/article/1cebc382a3f9483389844b884a3cbeb4
Autor:
Anthony Piron, Florian Szymczak, Maria Inês Alvelos, Matthieu Defrance, Tom Lenaerts, Décio L. Eizirik, Miriam Cnop
MotivationHigh throughput omics technologies have generated a wealth of large protein, gene and transcript datasets that have exacerbated the need for new methods to analyse and compare big datasets. Rank-rank hypergeometric overlap is an important t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cecb6db54a488b3e0a2e32959b8bc7b
https://doi.org/10.1101/2022.08.31.505818
https://doi.org/10.1101/2022.08.31.505818
Autor:
Catherine C. Robertson, Ruth M. Elgamal, Belle A. Henry-Kanarek, Peter Arvan, Shuibing Chen, Sangeeta Dhawan, Decio L. Eizirik, John S. Kaddis, Golnaz Vahedi, Stephen C.J. Parker, Kyle J. Gaulton, Scott A. Soleimanpour
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101973- (2024)
Background: Type 1 diabetes (T1D) is a complex multi-system disease which arises from both environmental and genetic factors, resulting in the destruction of insulin-producing pancreatic beta cells. Over the past two decades, human genetic studies ha
Externí odkaz:
https://doaj.org/article/2fd0a447e207481d8751377f9c298a7a
Autor:
Florian Szymczak, Maria Inês Alvelos, Sandra Marín-Cañas, Ângela Castela, Stéphane Demine, Maikel Luis Colli, Anne Op de Beeck, Sofia Thomaidou, Lorella Marselli, Arnaud Zaldumbide, Piero Marchetti, Décio L. Eizirik
Publikováno v:
Science advances.
IFNα is a key regulator of the dialogue between pancreatic β cells and the immune system in early type 1 diabetes (T1D). IFNα up-regulates HLA class I expression in human β cells, fostering autoantigen presentation to the immune system. We observ
Autor:
Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L. Eizirik, Bobbie-Jo M. Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O. Metz, Raghavendra G. Mirmira, Lori Sussel, Charles Ansong, Ernesto S. Nakayasu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-c
Externí odkaz:
https://doaj.org/article/6b57b4f4064a4390ae8f0840effa40ac